Lithium-sulfur(Li-S)battery can satisfy the need of the future power battery market because of its high energy density,but the hidden dangers caused by lithium anode have seriously hindered their commercialization.Her...Lithium-sulfur(Li-S)battery can satisfy the need of the future power battery market because of its high energy density,but the hidden dangers caused by lithium anode have seriously hindered their commercialization.Herein,an innovative gel polymer electrolyte(GPE)composed of polyvinylidene fluoride(PVDF)and organo-polysulfide polymer(PSPEG)is proposed,which could be used in semisolid-state Li-S batteries for protection of Li anodes.Particularly,organo-polysulfide polymer could chemically/electrochemically generate both inorganic and organic components simultaneously in-situ once contacting fresh Li metal surface and/or during discharging processes.And these inorganic/organic components could participate in the formation of the SEI layer and finally constitute a stable and flexible hybrid SEI layer on the surface of Li metal anode.Moreover,the organic components were permselective to lithium ions against anions.Therefore,PVDF/PSPEG GPE ensures the ideal chemical and electrochemical properties for Li-S batteries.Our work demonstrates an effective solution to solve the problems about Li anodes and contributes to the development of the safe Li metal batteries.展开更多
BACKGROUND Forkhead box protein 1(FOXP1)(OMIM:605515)at chromosomal region 3p14.1 plays an important regulatory role in cell development and functions by regulating genetic expression.Earlier studies have suggested th...BACKGROUND Forkhead box protein 1(FOXP1)(OMIM:605515)at chromosomal region 3p14.1 plays an important regulatory role in cell development and functions by regulating genetic expression.Earlier studies have suggested that FOXP1,an oncogene,is capable of initiating tumorigenicity depending on the cell type.FOXP1 also plays an important role in regulating the cell development and functions of the immune system,e.g.,regulating B-cell maturation and mononuclear phagocyte differentiation,and in the occurrence and development of various immune diseases.The mRNA of this gene is widely expressed in humans,and its differential expression is related to numerous diseases.CASE SUMMARY A 5-year-old boy mainly presented with attention deficit and hyperactivity disorder and developmental retardation accompanied by gait instability and abnormal facial features(low-set ears).DNA samples were extracted from the child’s and his parents’peripheral blood to detect whole-exome sequences and whole-genome copy number variations.Results revealed heterozygous deletions of exon 6-21 of FOXP1 gene in the child.Physical examination upon admission showed that the child was generally in good condition,had a moderate nutritional status,a slightly slow response to external stimuli,equally large and equally round bilateral pupils,was sensitive to light reflection,and had poor eye contact and joint attention.He had no meaningful utterance and could not pronounce words properly.He was able to use gestures to simply express his thoughts,to perform simple actions,and to listen to instructions.He had no rash,cafe-au-lait macules,or depigmentation spots.He had thick black hair and low-set ears.He had highly sensitive skin,especially on his face and palms.He had no abnormal palm fingerprint.Cardiopulmonary and abdominal examinations revealed no abnormalities.He had normal limb muscle strength and tension.He showed normal tendon reflexes of both knees.His bilateral Babinski and meningeal irritation signs were negative.He had a normal male vulva.CONCLUSION We report the characteristic features of autism with dysphasia accompanied by mental retardation caused by FOXP1 exon deletion.This study provides a molecular basis for etiological diagnosis and treatment of the child,as well as for genetic counseling for the pedigree.展开更多
Objective: To investigate the ultrasound assessment of left cardiac function in patients with gestational hypertension and its correlation with serum cytokine contents. Methods: A total of 76 patients with gestational...Objective: To investigate the ultrasound assessment of left cardiac function in patients with gestational hypertension and its correlation with serum cytokine contents. Methods: A total of 76 patients with gestational hypertension who were treated in Guangyuan Central Hospital between August 2015 and February 2017 were selected as gestational hypertension group, and 50 healthy pregnant women who received regular prenatal examination in Guangyuan Central Hospital during the same period were selected as normal control group. The differences in the ultrasonic left cardiac function parameter levels as well as serum contents of endothelial injury indexes and inflammatory factors were compared between the two groups of pregnant women. Pearson test was used to assess the correlation of ultrasonic left cardiac function parameter levels of gestational hypertension with serum endothelial injury index and inflammatory factor contents. Results: LAVmax, LVESV and LVEDV levels in gestational hypertension group were significantly higher than those in normal control group;serum endothelial injury indexes NO and PGE2 contents were lower than those of normal control group whereas ET-1 content was higher than that of normal control group;serum inflammatory factors IL-2, IFN-γ, IL-10, IL-13, IL-17 and IL-23 contents were significantly higher than those of normal control group. Correlation analysis showed that the ultrasonic left cardiac function parameter levels in patients with gestational hypertension were directly correlated with serum content of endothelial injury indexes and inflammatory factors. Conclusion: Ultrasonic left cardiac function parameter levels significantly change in patients with gestational hypertension, and the specific levels are directly correlated with the degree of endothelial injury and inflammatory response in the pregnant women.展开更多
With the exploration of novel sustainable protocol for functional polyamides'(PAs)construction as the starting point,herein,the small molecular model compound(M 1-ssBIC)was prepared firstly by manual grinding of m...With the exploration of novel sustainable protocol for functional polyamides'(PAs)construction as the starting point,herein,the small molecular model compound(M 1-ssBIC)was prepared firstly by manual grinding of monofunctional benzoxazine(1a)and isocyanide(1 b)via solid-state benzoxazine-isocyanide chemistry(ssBIC)to evaluate the feasibility of ssBIC.Linear PAs(P1-series polymers)were subsequently synthesized from biunctional benzoxazine(2a)and isocyanide(2b),and the influence of the loading of catalyst(octylphosphonic acid)(OPA)on the polymerization was investigated.Afterwards,two kinds of cross-linked PAs were successfully constructed via ssBIC by using trifunctional benzoxazine(3a)and cross-linked polybenzoxazine(4a)as reaction substrates,respectively,thus verifying the adaptability of ssBIC.Structural characterization indicates that amide,phenolic hydroxyl and tertiary amine substructures,with metal-complexing capability,have been successfully integrated into the obtained PAs.A type of representative PA/silver composite(P3-AgNPs)was prepared subsequently via in situ reduction treatment,and its application as recyclable reduction catalyst for organic pollutant p-nitrophenol(4-NP)was preliminarily investigated here to provide the example for possible downstream application of ssBIC.We think that this current work could provide a new pathway for the construction of functional PAs through facile and sustainable ssBIC protocol.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52174333,U1908225,1702253)the Fundamental Research Funds for Central Universities,China(Nos.N182515007,N170908001,N2025004).
基金supported by the National Natural Science Foundation of China(Grant No.21805016 and Grant No.51572037)the Natural Science Foundation of Jiangsu Province of China(No.BK20180961)+3 种基金the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.18KJD530001 and Grant No.18KJB430004)the Key Research and Development Project of Jiangsu Province(Grant No.BE2017006-3)the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions(TAPP)Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘Lithium-sulfur(Li-S)battery can satisfy the need of the future power battery market because of its high energy density,but the hidden dangers caused by lithium anode have seriously hindered their commercialization.Herein,an innovative gel polymer electrolyte(GPE)composed of polyvinylidene fluoride(PVDF)and organo-polysulfide polymer(PSPEG)is proposed,which could be used in semisolid-state Li-S batteries for protection of Li anodes.Particularly,organo-polysulfide polymer could chemically/electrochemically generate both inorganic and organic components simultaneously in-situ once contacting fresh Li metal surface and/or during discharging processes.And these inorganic/organic components could participate in the formation of the SEI layer and finally constitute a stable and flexible hybrid SEI layer on the surface of Li metal anode.Moreover,the organic components were permselective to lithium ions against anions.Therefore,PVDF/PSPEG GPE ensures the ideal chemical and electrochemical properties for Li-S batteries.Our work demonstrates an effective solution to solve the problems about Li anodes and contributes to the development of the safe Li metal batteries.
基金Supported by Natural Science Foundation of Jilin Province,No.20200201486JC.
文摘BACKGROUND Forkhead box protein 1(FOXP1)(OMIM:605515)at chromosomal region 3p14.1 plays an important regulatory role in cell development and functions by regulating genetic expression.Earlier studies have suggested that FOXP1,an oncogene,is capable of initiating tumorigenicity depending on the cell type.FOXP1 also plays an important role in regulating the cell development and functions of the immune system,e.g.,regulating B-cell maturation and mononuclear phagocyte differentiation,and in the occurrence and development of various immune diseases.The mRNA of this gene is widely expressed in humans,and its differential expression is related to numerous diseases.CASE SUMMARY A 5-year-old boy mainly presented with attention deficit and hyperactivity disorder and developmental retardation accompanied by gait instability and abnormal facial features(low-set ears).DNA samples were extracted from the child’s and his parents’peripheral blood to detect whole-exome sequences and whole-genome copy number variations.Results revealed heterozygous deletions of exon 6-21 of FOXP1 gene in the child.Physical examination upon admission showed that the child was generally in good condition,had a moderate nutritional status,a slightly slow response to external stimuli,equally large and equally round bilateral pupils,was sensitive to light reflection,and had poor eye contact and joint attention.He had no meaningful utterance and could not pronounce words properly.He was able to use gestures to simply express his thoughts,to perform simple actions,and to listen to instructions.He had no rash,cafe-au-lait macules,or depigmentation spots.He had thick black hair and low-set ears.He had highly sensitive skin,especially on his face and palms.He had no abnormal palm fingerprint.Cardiopulmonary and abdominal examinations revealed no abnormalities.He had normal limb muscle strength and tension.He showed normal tendon reflexes of both knees.His bilateral Babinski and meningeal irritation signs were negative.He had a normal male vulva.CONCLUSION We report the characteristic features of autism with dysphasia accompanied by mental retardation caused by FOXP1 exon deletion.This study provides a molecular basis for etiological diagnosis and treatment of the child,as well as for genetic counseling for the pedigree.
文摘Objective: To investigate the ultrasound assessment of left cardiac function in patients with gestational hypertension and its correlation with serum cytokine contents. Methods: A total of 76 patients with gestational hypertension who were treated in Guangyuan Central Hospital between August 2015 and February 2017 were selected as gestational hypertension group, and 50 healthy pregnant women who received regular prenatal examination in Guangyuan Central Hospital during the same period were selected as normal control group. The differences in the ultrasonic left cardiac function parameter levels as well as serum contents of endothelial injury indexes and inflammatory factors were compared between the two groups of pregnant women. Pearson test was used to assess the correlation of ultrasonic left cardiac function parameter levels of gestational hypertension with serum endothelial injury index and inflammatory factor contents. Results: LAVmax, LVESV and LVEDV levels in gestational hypertension group were significantly higher than those in normal control group;serum endothelial injury indexes NO and PGE2 contents were lower than those of normal control group whereas ET-1 content was higher than that of normal control group;serum inflammatory factors IL-2, IFN-γ, IL-10, IL-13, IL-17 and IL-23 contents were significantly higher than those of normal control group. Correlation analysis showed that the ultrasonic left cardiac function parameter levels in patients with gestational hypertension were directly correlated with serum content of endothelial injury indexes and inflammatory factors. Conclusion: Ultrasonic left cardiac function parameter levels significantly change in patients with gestational hypertension, and the specific levels are directly correlated with the degree of endothelial injury and inflammatory response in the pregnant women.
基金supported by the National Natural Science Foundation of China(No.21774103)the Youth Science and Technology Innovation Team of SWPU(Nos.2017CXTD05,2018CXTD05).
文摘With the exploration of novel sustainable protocol for functional polyamides'(PAs)construction as the starting point,herein,the small molecular model compound(M 1-ssBIC)was prepared firstly by manual grinding of monofunctional benzoxazine(1a)and isocyanide(1 b)via solid-state benzoxazine-isocyanide chemistry(ssBIC)to evaluate the feasibility of ssBIC.Linear PAs(P1-series polymers)were subsequently synthesized from biunctional benzoxazine(2a)and isocyanide(2b),and the influence of the loading of catalyst(octylphosphonic acid)(OPA)on the polymerization was investigated.Afterwards,two kinds of cross-linked PAs were successfully constructed via ssBIC by using trifunctional benzoxazine(3a)and cross-linked polybenzoxazine(4a)as reaction substrates,respectively,thus verifying the adaptability of ssBIC.Structural characterization indicates that amide,phenolic hydroxyl and tertiary amine substructures,with metal-complexing capability,have been successfully integrated into the obtained PAs.A type of representative PA/silver composite(P3-AgNPs)was prepared subsequently via in situ reduction treatment,and its application as recyclable reduction catalyst for organic pollutant p-nitrophenol(4-NP)was preliminarily investigated here to provide the example for possible downstream application of ssBIC.We think that this current work could provide a new pathway for the construction of functional PAs through facile and sustainable ssBIC protocol.