The paper presents GEneral ReadOut (GERO), a general readout ASIC based on a switched capacitor array for micro-pattern gas detectors. It aims at providing general readout electronics for low-to-medium event-rate gas ...The paper presents GEneral ReadOut (GERO), a general readout ASIC based on a switched capacitor array for micro-pattern gas detectors. It aims at providing general readout electronics for low-to-medium event-rate gas detectors with high sampling frequency, configurable storage depth, and data digitalization. The first prototype GERO chip integrates 16 channels and was fabricated using a 0.18-lm CMOS process. Each channel consists of a sampling array working in a ping-pong mode, a storage array with a 1024-cell depth, and 32 Wilkinson analog-todigital converters. The detailed design and test results are presented in the paper.展开更多
NH3-plasma treatment is used to improve the quality of the gate dielectric and interface. Al2O3 is adopted as a buffer layer between HfO2 and MoS2 to decrease the interface-state density. Four groups of MOS capacitors...NH3-plasma treatment is used to improve the quality of the gate dielectric and interface. Al2O3 is adopted as a buffer layer between HfO2 and MoS2 to decrease the interface-state density. Four groups of MOS capacitors and back-gate transistors with different gate dielectrics are fabricated and their C–V and I–V characteristics are compared. It is found that the Al2O3/HfO2 back-gate transistor with NH3-plasma treatment shows the best electrical performance: high on–off current ratio of 1.53 × 107, higher field-effect mobility of 26.51 cm2/V·s, and lower subthreshold swing of 145 m V/dec.These are attributed to the improvements of the gate dielectric and interface qualities by the NH3-plasma treatment and the addition of Al2O3 as a buffer layer.展开更多
Dietary protein(P)and carbohydrate(C)have a major impact on the sweet taste sensation.However,it remains unclear whether the balance of P and C influences the sweet taste sensitivity.Here,we use the nutritional geomet...Dietary protein(P)and carbohydrate(C)have a major impact on the sweet taste sensation.However,it remains unclear whether the balance of P and C influences the sweet taste sensitivity.Here,we use the nutritional geometry framework(NGF)to address the interaction of protein and carbohydrates on sweet taste using Drosophila as a model.Our results reveal that high-protein,low-carbohydrate(HPLC)diets sensitize to sweet taste and low-protein,high-carbohydrate(LPHC)diets desensitize sweet taste in both male and female flies.We further investigate the underlying mechanisms of the effects of two diets on sweet taste using RNA sequencing.When compared to the LPHC diet,the m RNA expression of genes involved in the metabolism of glycine,serine,and threonine is significantly upregulated in the HPLC diet group,suggesting these amino acids may mediate sweet taste perception.We further find that sweet sensitization occurs in flies fed with the LPHC diet supplemented with serine and threonine.Our study demonstrates that sucrose taste sensitivity is affected by the balance of dietary protein and carbohydrates possibly through changes in serine and threonine.展开更多
In this paper,we provide some gentle introductions to the recent advance in augmented Lagrangian methods for solving large-scale convex matrix optimization problems(cMOP).Specifically,we reviewed two types of sufficie...In this paper,we provide some gentle introductions to the recent advance in augmented Lagrangian methods for solving large-scale convex matrix optimization problems(cMOP).Specifically,we reviewed two types of sufficient conditions for ensuring the quadratic growth conditions of a class of constrained convex matrix optimization problems regularized by nonsmooth spectral functions.Under a mild quadratic growth condition on the dual of cMOP,we further discussed the R-superlinear convergence of the Karush-Kuhn-Tucker(KKT)residuals of the sequence generated by the augmented Lagrangian methods(ALM)for solving convex matrix optimization problems.Implementation details of the ALM for solving core convex matrix optimization problems are also provided.展开更多
基金supported by the National Natural Science Foundation of China(Nos.11675197 and 11775242)
文摘The paper presents GEneral ReadOut (GERO), a general readout ASIC based on a switched capacitor array for micro-pattern gas detectors. It aims at providing general readout electronics for low-to-medium event-rate gas detectors with high sampling frequency, configurable storage depth, and data digitalization. The first prototype GERO chip integrates 16 channels and was fabricated using a 0.18-lm CMOS process. Each channel consists of a sampling array working in a ping-pong mode, a storage array with a 1024-cell depth, and 32 Wilkinson analog-todigital converters. The detailed design and test results are presented in the paper.
基金Project supported by the National Natural Science Foundation of China(Grant No.61774064)
文摘NH3-plasma treatment is used to improve the quality of the gate dielectric and interface. Al2O3 is adopted as a buffer layer between HfO2 and MoS2 to decrease the interface-state density. Four groups of MOS capacitors and back-gate transistors with different gate dielectrics are fabricated and their C–V and I–V characteristics are compared. It is found that the Al2O3/HfO2 back-gate transistor with NH3-plasma treatment shows the best electrical performance: high on–off current ratio of 1.53 × 107, higher field-effect mobility of 26.51 cm2/V·s, and lower subthreshold swing of 145 m V/dec.These are attributed to the improvements of the gate dielectric and interface qualities by the NH3-plasma treatment and the addition of Al2O3 as a buffer layer.
基金funded by the National Natural Science Foundation of China(31800993,31970934)Natural Science of Foundation of Guangdong,China(2018B030306002)Science and Technology Innovation Committee of Shenzhen,China(201908073000449)to Q.P.W。
文摘Dietary protein(P)and carbohydrate(C)have a major impact on the sweet taste sensation.However,it remains unclear whether the balance of P and C influences the sweet taste sensitivity.Here,we use the nutritional geometry framework(NGF)to address the interaction of protein and carbohydrates on sweet taste using Drosophila as a model.Our results reveal that high-protein,low-carbohydrate(HPLC)diets sensitize to sweet taste and low-protein,high-carbohydrate(LPHC)diets desensitize sweet taste in both male and female flies.We further investigate the underlying mechanisms of the effects of two diets on sweet taste using RNA sequencing.When compared to the LPHC diet,the m RNA expression of genes involved in the metabolism of glycine,serine,and threonine is significantly upregulated in the HPLC diet group,suggesting these amino acids may mediate sweet taste perception.We further find that sweet sensitization occurs in flies fed with the LPHC diet supplemented with serine and threonine.Our study demonstrates that sucrose taste sensitivity is affected by the balance of dietary protein and carbohydrates possibly through changes in serine and threonine.
基金Chao Ding’s research was supported by the National Natural Science Foundation of China(Nos.11671387,11531014,and 11688101)Beijing Natural Science Foundation(No.Z190002)+6 种基金Xu-Dong Li’s research was supported by the National Key R&D Program of China(No.2020YFA0711900)the National Natural Science Foundation of China(No.11901107)the Young Elite Scientists Sponsorship Program by CAST(No.2019QNRC001)the Shanghai Sailing Program(No.19YF1402600)the Science and Technology Commission of Shanghai Municipality Project(No.19511120700)Xin-Yuan Zhao’s research was supported by the National Natural Science Foundation of China(No.11871002)the General Program of Science and Technology of Beijing Municipal Education Commission(No.KM201810005004).
文摘In this paper,we provide some gentle introductions to the recent advance in augmented Lagrangian methods for solving large-scale convex matrix optimization problems(cMOP).Specifically,we reviewed two types of sufficient conditions for ensuring the quadratic growth conditions of a class of constrained convex matrix optimization problems regularized by nonsmooth spectral functions.Under a mild quadratic growth condition on the dual of cMOP,we further discussed the R-superlinear convergence of the Karush-Kuhn-Tucker(KKT)residuals of the sequence generated by the augmented Lagrangian methods(ALM)for solving convex matrix optimization problems.Implementation details of the ALM for solving core convex matrix optimization problems are also provided.