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Distribution of Metabolites in Root Barks of Seven Tree Peony Cultivars for Quality Assessment Using NMR-based Metabolomics 被引量:6
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作者 Pei Wang Ze-ming Rong +3 位作者 Cui-xia Ma xin-feng zhao Chao-ni Xiao Xiao-hui Zheng 《Chinese Herbal Medicines》 CAS 2017年第1期31-41,共11页
Objective To determine the distribution of metabolites in the root barks of different tree peony cultivars for quality assessment. Methods Seven tree peony phenotypic cultivars with different colors were systematicall... Objective To determine the distribution of metabolites in the root barks of different tree peony cultivars for quality assessment. Methods Seven tree peony phenotypic cultivars with different colors were systematically analyzed using NMR-based metabolomics. Results A total of 16 metabolites from their methanol extracts were simultaneously identified and quantified, including one primary metabolite (sucrose) and 15 secondary ones (acetophenones, phenolics, monoterpene glycosides, flavonoids, and unsaturated fatty acids). The quantitative data indicated that sucrose (90-180 mg/g) and acetophenones (15-100 mg/g), and non-phenolics, monoterpene glycosides, flavonoids, and unsaturated fatty acids (2-15 mg/g) were the major metabolites in these tree peony cultivars. The significantly increasing levels of paeonoside with bioactivity were observed in "Xiangyu", "Wujinyaohui", "Roufurong", "Yaohuang", "Zhaofen", "Doulu", and "Yingrihong" in order. Opposite trends in the levels of paeonoside and paeonol were observed in "Xiangyu" and "Yingrihong", suggesting that the changes of the secondary metabolites in plants were influenced by primary metabolites, such as sucrose/glucose, and the different physiological processes occurred in different tree peony cultivars. Conclusion "Yingrihong" with red flower has the highest medicine quality whereas "Xiangyu" with white flower has the worst one based on the content of paeonoside. 展开更多
关键词 metabolomics NMR quality assessment tree peony
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Metabolite characterization of Penta-O-galloyl-β-D-glucose in rat biofluids by HPLC-QTOF-MS
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作者 cui-xia ma xue zhao +4 位作者 pei wang pu jia xin-feng zhao chao-ni xiao xiao-hui zheng 《Chinese Herbal Medicines》 CAS 2018年第1期73-79,共7页
Objective: To understand the in vivo metabolic fate of 1,2,3,4,6-Penta-O-galloyl-β-d-glucose(PGG)naturally existed in many medicinal herbs and food plants such as Rhus chinensis,Paeonia suffruticosa,Paeonia lactif... Objective: To understand the in vivo metabolic fate of 1,2,3,4,6-Penta-O-galloyl-β-d-glucose(PGG)naturally existed in many medicinal herbs and food plants such as Rhus chinensis,Paeonia suffruticosa,Paeonia lactiflora and Mango.Methods: The metabolites of PGG in rat biofluids were characterized using high performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry(HPLC-QTOF-MS).Results: Ten metabolites in urine,five metabolites in feces and two metabolites in plasma,were observed when the rats were administrated with a single intravenous injection of PGG(20 mg/kg).Conclusion: PGG is firstly metabolized to gallic acid,then gallic acid undergoes sulfation,glucuronidation and methylation by rat liver.The determination of metabolites and the proposed metabolic pathway of PGG in vivo will be benefit to gain deeper insights into its pharmacological activities. 展开更多
关键词 1 2 3 4 6-Penta-O-galloyl-β-D-glucose (PGG)HPLC-QTOF-MSmetabolic pathway
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