Dear Editor,Extracellular vesicles,especially exosomes,have emerged as promising diagnostic sources for cancers due to their easy and quick accessibility.1,2 Additionally,it has been demonstrated that circulating miRN...Dear Editor,Extracellular vesicles,especially exosomes,have emerged as promising diagnostic sources for cancers due to their easy and quick accessibility.1,2 Additionally,it has been demonstrated that circulating miRNAs serve as promising biomarkers for the diagnosis of multiple diseases.3,4 Cholangiocarcinoma(CCA)and gallbladder carcinoma(GBC)are two malignant biliary tract cancers.It has been estimated that patients with unresectable GBC have a 5-year survival of only less than 5%,while CCA patients suffer from an overall 5-year survival of~10%.5 Hence,circulating diagnostic biomarkers would benefit the diagnosis and treatment of GBC and CCA patients.We sequenced exosomal small RNA from five CCA patients and four GBC patients before and after surgery and enrolled 40 healthy individuals,45 more CCA patients and 24 more GBC patients to validate the sequencing results to identify diagnostic biomarkers for GBC and CCA.展开更多
基金supported by the National Natural Science Foundation of China(81772798)National Natural Science Fund Youth Project(81700007)+3 种基金Research and Innovation Fund of the Ministry of Education(2018A03026)Beijing Natural Science Foundation(2019A10)“Qingmiao”Project of Beijing Municipal Hospital Administration(2018QM4)Beijing Top Talent Project(2018000021223ZK11).
文摘Dear Editor,Extracellular vesicles,especially exosomes,have emerged as promising diagnostic sources for cancers due to their easy and quick accessibility.1,2 Additionally,it has been demonstrated that circulating miRNAs serve as promising biomarkers for the diagnosis of multiple diseases.3,4 Cholangiocarcinoma(CCA)and gallbladder carcinoma(GBC)are two malignant biliary tract cancers.It has been estimated that patients with unresectable GBC have a 5-year survival of only less than 5%,while CCA patients suffer from an overall 5-year survival of~10%.5 Hence,circulating diagnostic biomarkers would benefit the diagnosis and treatment of GBC and CCA patients.We sequenced exosomal small RNA from five CCA patients and four GBC patients before and after surgery and enrolled 40 healthy individuals,45 more CCA patients and 24 more GBC patients to validate the sequencing results to identify diagnostic biomarkers for GBC and CCA.
