[ Objective] The paper was to study the insecticidal activity and field efficacy of cyhalediamide, a novel insecticide developed by Zhejiang Research Institute of Chemical Industry, Ltd. [ Method] Toxicity of cyhalodi...[ Objective] The paper was to study the insecticidal activity and field efficacy of cyhalediamide, a novel insecticide developed by Zhejiang Research Institute of Chemical Industry, Ltd. [ Method] Toxicity of cyhalodiamide against Plutella xylostella, Spodoptera exigua, Prodenia litura and Chilo suppressalis were tasted in the laboratory by leaf-dipping method, and the field efficacy of cyhalodiamide against P. xylostella, S. exigua, P. litura, Pieris rapae, C. suppressalis and Cnaphalocrocis medinalis was evaluated. [ Result] The LCs0 values of cyhalodiamide against P. xylostella, S. exigua, P. litura and C. suppressalis were 0. 046, 0.072, 0.071 and 1.95 mg/L, respectively, almost equivalent to that of flubendiamide and ehlorantraniliprole. The control efficacy of 20% Z4042 SC （30 g/hm2） against P. xylostella, S. exigua, P. litura and P. rapae was 90.1% - 96.3 % after spraying for 7 d, and its control efficacy against C. suppressalis and C. medinalis was 82.9% -90.5% after spraying for 15 d. No crop injury was observed at the test dosage. [Conclusion] The study provided reference for field control against Lepidoptera pests.展开更多
To make further studies on the difference of cis-nitenpyram analogues, a series of cis-nitenpyram com- pounds containing a flexible amido segment anchored on tetrahydropyrimidine ring was designed and synthesized. Pre...To make further studies on the difference of cis-nitenpyram analogues, a series of cis-nitenpyram com- pounds containing a flexible amido segment anchored on tetrahydropyrimidine ring was designed and synthesized. Preliminary bioassays indicate that all the analogues exhibit a mortality of 100% at 100 rag/L, and the analogue 4d shows the best activity against Nilaparvata lugens and Myzus persicae, with a mortality of 100% at 4 mg/L （LCs0=0.172 rag/L）. The structure activity relationship studies show that insecticidal activities of the analogues are affected by the kinds and size of substituent R. In addition, the molecular docking simulations reveal that compouds 4 with a flexible amido segment on tetrahydropyrimidine ring show their different binding affinities for the nicotinic acetyleholine receptor（nAChR） of insect and compoud 4d shows stronger hydrogen-bonding with nAChR, which may provide the structure-activity relationship observed in vitro.展开更多
基金Supported by"Twelfth Five-Year"National Science and Technology Support Program(2011BAE06B01-20)
文摘[ Objective] The paper was to study the insecticidal activity and field efficacy of cyhalediamide, a novel insecticide developed by Zhejiang Research Institute of Chemical Industry, Ltd. [ Method] Toxicity of cyhalodiamide against Plutella xylostella, Spodoptera exigua, Prodenia litura and Chilo suppressalis were tasted in the laboratory by leaf-dipping method, and the field efficacy of cyhalodiamide against P. xylostella, S. exigua, P. litura, Pieris rapae, C. suppressalis and Cnaphalocrocis medinalis was evaluated. [ Result] The LCs0 values of cyhalodiamide against P. xylostella, S. exigua, P. litura and C. suppressalis were 0. 046, 0.072, 0.071 and 1.95 mg/L, respectively, almost equivalent to that of flubendiamide and ehlorantraniliprole. The control efficacy of 20% Z4042 SC （30 g/hm2） against P. xylostella, S. exigua, P. litura and P. rapae was 90.1% - 96.3 % after spraying for 7 d, and its control efficacy against C. suppressalis and C. medinalis was 82.9% -90.5% after spraying for 15 d. No crop injury was observed at the test dosage. [Conclusion] The study provided reference for field control against Lepidoptera pests.
文摘To make further studies on the difference of cis-nitenpyram analogues, a series of cis-nitenpyram com- pounds containing a flexible amido segment anchored on tetrahydropyrimidine ring was designed and synthesized. Preliminary bioassays indicate that all the analogues exhibit a mortality of 100% at 100 rag/L, and the analogue 4d shows the best activity against Nilaparvata lugens and Myzus persicae, with a mortality of 100% at 4 mg/L （LCs0=0.172 rag/L）. The structure activity relationship studies show that insecticidal activities of the analogues are affected by the kinds and size of substituent R. In addition, the molecular docking simulations reveal that compouds 4 with a flexible amido segment on tetrahydropyrimidine ring show their different binding affinities for the nicotinic acetyleholine receptor（nAChR） of insect and compoud 4d shows stronger hydrogen-bonding with nAChR, which may provide the structure-activity relationship observed in vitro.
