Prevalence and risk factors of depression among patients with perianal fistulizing Crohn’s disease

BACKGROUND Psychological distress,especially depression,associated with perianal fistulizing Crohn’s disease(PFCD)is widespread and refractory.However,there is a surprising paucity of studies to date that have sought to identify the prevalence and risk factors of depression associated with PFCD.AIM To estimate the prevalence of depressive symptoms and investigate the depression-related risk factors in patients with PFCD.METHODS The study was conducted in the form of survey and clinical data collection via questionnaire and specialized medical staff.Depressive symptoms,life quality,and fatigue severity of patients with PFCD were assessed by Patient Health Questionnaire-9,Inflammatory Bowel Disease Patient Quality of Life Questionnaire(IBDQ),and Inflammatory Bowel Disease(IBD)Fatigue Patient Self-assessment Scale.The basic demographic information,overall disease features,perianal clinical information,and laboratory inflammation indicators were also gathered.Multivariate regression analysis was ultimately used to ascertain the risk factors of depression associated with PFCD.RESULTS A total of 123 patients with PFCD were involved,and 56.91%were suffering from depression.According to multivariate logistic regression analysis,Perianal Disease Activity Index(PDAI)score[odds ratio(OR)=0.69,95%confidence interval(CI):0.50 to 0.95],IBDQ score(OR=0.93,95%CI:0.88 to 0.97),modified Van Assche index(OR=1.24,95%CI:1.01 to 1.53),and IBD Fatigue score(OR=1.72,95%CI:1.23 to 2.42)were independent risk factors of depression-related prevalence among patients with PFCD(P<0.05).Multiple linear regression analysis revealed that the increasing perianal modified Van Assche index(βvalue=0.166,95%CI:0.02 to 0.31)and decreasing IBDQ score(βvalue=-0.116,95%CI:-0.14 to-0.09)were independently associated with the severity of depression(P<0.05).CONCLUSION Depressive symptoms in PFCD patients have significantly high prevalence.PDAI score,modified Van Assche index,quality of life,and fatigue severity were the main independent risk factors.

Nursing Care Management Strategies in Isolation Wards during the COVID-19 Outbreak

Coronavirus disease 2019 (COVID-19) is highly infectious and has spread worldwide. Medical staff may be exposed to the infection under circumstances of medical supply shortages and improper protection. How to better protect medical staff has become the focus of all walks of life. Therefore, during the COVID-19 outbreak, timely adjustments and optimization of nursing management strategies in isolation wards are important for improving care quality and reducing the infection of medical staff. Based on a literature review and clinical nursing management practices, this article summarizes the nursing management strategies in isolation wards during the COVID-19 outbreak, aiming to provide references for clinical nursing managers.

Preparation and in vitro Evaluation of Salidroside Nanoparticle

[Objectives]To use poly(lactic-co-glycolic acid)(PLGA)nanoparticles to improve the bioavailability and brain entrance capability of Salidroside(Sal).[Methods]An emulsion solvent evaporation approach was used to create PLGA nanoparticles(Sal-NP).The preparation parameters were optimized using a single factor experiment.The particle size and zeta potential were determined using the laser particle analyzer,and the morphology of the nanoparticles was observed using transmission electron microscopy.The encapsulation efficiency and drug loading were determined using HPLC.Subsequently,the in vitro drug release was determined using a dynamic dialysis method,and the cellular uptake and cytotoxicity were determined using the bEnd3 cell model.[Results]The ultrasonic time and power for preparing Sal-NP were 6 min and 100 W,respectively.The size of the nanoparticles was 162.0±74.86 nm,and the morphology of Sal-NP was spherical like.After 48 h,the cumulative release of Sal-NP was 62%,indicating that Sal showed a controlled release property in Sal-NP.Cellular uptake study showed that the PLGA nanoparticles remarkably increased the internalization than control group(P<0.001).In addition,Sal-NPs were non-toxic to cells at concentrations ranging from 12.5 to 100μM.[Conclusions]PLGA nanoparticles is promising to be exploited in Alzheimer's disease research due to the increasing absorption and controlled release advantages for Sal.

A Brief Analysis of English Advertising at Lexical Level and Syntactical Level

Advertising language,playing a role of communication and persuasion,has developed its own features.Although words and syntax play an essential role in advertising,the techniques used at lexical level and syntactical level by advertisers do not vary markedly.This paper presents an analytical study of major similar language features used in English advertisements.

海洋经济发展试点政策对区域经济韧性的影响——基于沿海地区的准自然实验

为了推动陆海统筹,转变和优化临海产业布局,制定和完善海洋开发政策与体制建设,推进海洋经济发展和海洋强国战略,提高沿海区域经济发展韧性水平,中国自2011年以来先后启动海洋经济发展试点工作。旅游业是中国沿海区域经济的重要组成部分。论文以海洋经济发展试点政策作为准自然实验,基于2007—2020年中国沿海地区各地级及以上城市的面板数据,运用多期双重差分模型,总结和评估该试点政策对区域经济韧性及旅游经济韧性的影响。结果表明:海洋经济发展试点政策的实施能够显著推动区域经济韧性及旅游经济韧性的提升;而新冠疫情事件作为调节变量,削弱了海洋经济发展试点政策对区域经济韧性的影响。在区域异质性上,海洋经济发展试点对中南沿海地区经济韧性的政策效应最明显,而对华东沿海地区旅游经济韧性的政策效应则更为显著。鉴于此,合理扩大海洋经济发展试点,因地制宜规划沿海区域经济体系,对防范系统性风险、提高区域经济韧性及旅游经济韧性具有重要意义。

我国绿色金融对旅游业高质量发展的影响研究——基于省级面板数据的空间计量分析

本文构建我国绿色金融对旅游业高质量发展作用路径的逻辑框架;建立绿色金融发展水平与旅游业高质量发展水平指标体系,利用熵值法对2008—2019年30个省相应水平进行测度;运用空间杜宾模型,探讨绿色金融对旅游业高质量发展的空间作用,并考察碳生产率在该作用路径中的中介效应。结果表明:绿色金融对旅游业高质量发展有显著影响,旅游业高质量发展水平和碳生产率均具有空间自相关性;在空间效应中,直接效应表现为正向溢出,间接效应则为负向抑制;碳生产率在该作用路径中可作为中介变量。今后我国应进一步深化金融体制改革,推进绿色金融发展,重视环境要素,提升碳生产率,完善区域联动机制,促进旅游业高质量发展。