Multifunctional Perovskite Photodetectors: From Molecular-Scale Crystal Structure Design to Micro/Nano-scale Morphology Manipulation

Multifunctional photodetectors boost the development of traditional optical communication technology and emerging artificial intelligence fields, such as robotics and autonomous driving. However, the current implementation of multifunctional detectors is based on the physical combination of optical lenses, gratings, and multiple photodetectors, the large size and its complex structure hinder the miniaturization, lightweight, and integration of devices. In contrast, perovskite materials have achieved remarkable progress in the field of multifunctional photodetectors due to their diverse crystal structures, simple morphology manipulation, and excellent optoelectronic properties. In this review, we first overview the crystal structures and morphology manipulation techniques of perovskite materials and then summarize the working mechanism and performance parameters of multifunctional photodetectors. Furthermore, the fabrication strategies of multifunctional perovskite photodetectors and their advancements are highlighted, including polarized light detection, spectral detection, angle-sensing detection, and selfpowered detection. Finally, the existing problems of multifunctional detectors and the perspectives of their future development are presented.

LITTIP/Lgr6/HnRNPK complex regulates cementogenesis via Wnt signaling

Orthodontically induced tooth root resorption(OIRR)is a serious complication during orthodontic treatment.Stimulating cementum repair is the fundamental approach for the treatment of OIRR.Parathyroid hormone(PTH)might be a potential therapeutic agent for OIRR,but its effects still lack direct evidence,and the underlying mechanisms remain unclear.This study aims to explore the potential involvement of long noncoding RNAs(lncRNAs)in mediating the anabolic effects of intermittent PTH and contributing to cementum repair,as identifying lncRNA-disease associations can provide valuable insights for disease diagnosis and treatment.Here,we showed that intermittent PTH regulates cell proliferation and mineralization in immortalized murine cementoblast OCCM-30 via the regulation of the Wnt pathway.In vivo,daily administration of PTH is sufficient to accelerate root regeneration by locally inhibiting Wnt/β-catenin signaling.Through RNA microarray analysis,lncRNA LITTIP(LGR6 intergenic transcript under intermittent PTH)is identified as a key regulator of cementogenesis under intermittent PTH.Chromatin isolation by RNA purification(ChIRP)and RNA immunoprecipitation(RIP)assays revealed that LITTIP binds to mRNA of leucine-rich repeatcontaining G-protein coupled receptor 6(LGR6)and heterogeneous nuclear ribonucleoprotein K(HnRNPK)protein.Further cotransfection experiments confirmed that LITTIP plays a structural role in the formation of the LITTIP/Lgr6/HnRNPK complex.Moreover,LITTIP is able to promote the expression of LGR6 via the RNA-binding protein HnRNPK.Collectively,our results indicate that the intermittent PTH administration accelerates root regeneration via inhibiting Wnt pathway.The lncRNA LITTIP is identified to negatively regulate cementogenesis,which activates Wnt/β-catenin signaling via high expression of LGR6 promoted by HnRNPK.

Experimental Study of Moist Exposed Burn Therapy/Moist Exposed Burn Ointment Combined with Zhuang Medicine Detoxification for Chronic Refractory Wound Healing

Background: This is still a public problem that needs to be solved urgently: chronic and refractory wound healing with long course and complex pathological mechanism. At present, there is still a lack of effective clinical treatment. This study, therefore, aims at exploring moist exposed burn therapy/moist exposed burn ointment (MEBT/MEBO) combined with Zhuang medicine detoxification in the treatment of chronic refractory wound healing. Methodology: 100 SPF Wistar rats were randomly divided into blank control group, model control group, MEBO group, Zhuang medicine group and Combined group, with 20 rats in each group. Open wound model was established in blank control group, and chronic refractory wound model was established in other groups. Black control group and model control group were given food and water freely, MEBO group was given dressing change once a day, Zhuang medicine group was given intragastric administration once a day, and combined group was given dressing change and intragastric administration once a day. The effective rate of wound healing was observed after 12 days of continuous intervention. Conclusion: Skin regeneration medical technique combined with Zhuang medicine poison theory can effectively reduce the symptoms of bleeding and exudation, reduce the area of wound, shorten the healing time of wound, and achieve physiological healing of wound. It has a good effect on chronic refractory wound.

基于深度全连接神经网络的大坝变形预测研究

将深度全连接神经网络引入大坝变形预测领域,结合大坝多源监测数据的训练样本,建立基于深度全连接神经网络的大坝变形预测模型。利用几种常见的深度优化学习算法对模型进行优化训练,通过对比各损失函数的变化曲线选取最优学习算法,进一步构建基于最优学习算法的深度全连接神经网络大坝变形预测模型;最后结合大坝多源监测数据的测试样本对模型进行检验分析,并将预测结果和传统BP神经网络的预测结果进行对比。研究结果表明,本文的深度全连接神经网络模型预测精度高、实用性强,可为大坝安全监控提供参考。

Autophagy in bone homeostasis and the onset of osteoporosis

Autophagy is an evolutionarily conserved intracellular process,in which domestic cellular components are selectively digested for the recycling of nutrients and energy.This process is indispensable for cell homeostasis maintenance and stress responses.Both genetic and functional studies have demonstrated that multiple proteins involved in autophagic activities are critical to the survival,differentiation,and functioning of bone cells,including osteoblasts,osteocytes,and osteoclasts.Dysregulation at the level of autophagic activity consequently disturbs the balance between bone formation and bone resorption and mediates the onset and progression of multiple bone diseases,including osteoporosis.This review aims to introduce the topic of autophagy,summarize the understanding of its relevance in bone physiology,and discuss its role in the onset of osteoporosis and therapeutic potential.

Condition-based maintenance optimization for continuously monitored degrading systems under imperfect maintenance actions

Condition-based maintenance(CBM) is receiving increasing attention in various engineering systems because of its effectiveness. This paper formulates a new CBM optimization problem for continuously monitored degrading systems considering imperfect maintenance actions. In terms of maintenance actions,in practice, they scarcely restore the system to an as-good-as new state due to residual damage. According to up-to-data researches, imperfect maintenance actions are likely to speed up the degradation process. Regarding the developed CBM optimization strategy, it can balance the maintenance cost and the availability by the searching the optimal preventive maintenance threshold.The maximum number of maintenance is also considered, which is regarded as an availability constraint in the CBM optimization problem. A numerical example is introduced, and experimental results can demonstrate the novelty, feasibility and flexibility of the proposed CBM optimization strategy.

求解函数最优解的改进灰狼算法

针对基本灰狼算法应用于函数优化问题时易陷入局部最优且求解全局最优解精度差的问题,提出了一种改进的灰狼算法。通过分析问题出现的根源,改进算法采用个体随机选择性策略修改了基本灰狼算法在全局搜索过程中的更新公式,用以调整算法局部搜索和全局搜索之间的相互平衡。通过对多个基准测试函数的数值分析实验,在与其它几种优化算法的比较中,结果表明:改进的灰狼算法是有效的,在搜索精度、稳定性以及收敛速度上均有明显的提升。

circ_0003204 regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p/HDAC4 axis

Human adipose-derived stem cells(hASCs)are a promising cell type for bone tissue regeneration.Circular RNAs(circRNAs)have been shown to play a critical role in regulating various cell differentiation and involve in mesenchymal stem cell osteogenesis.However,how circRNAs regulate hASCs in osteogenesis is still unclear.Herein,we found circ_0003204 was significantly downregulated during osteogenic differentiation of hASCs.Knockdown of circ_0003204 by si RNA or overexpression by lentivirus confirmed circ_0003204 could negatively regulate the osteogenic differentiation of hASCs.We performed dual-luciferase reporting assay and rescue experiments to verify circ_0003204 regulated osteogenic differentiation via sponging miR-370-3p.We predicted and confirmed that miR-370-3p had targets in the 3′-UTR of HDAC4 m RNA.The following rescue experiments indicated that circ_0003204 regulated the osteogenic differentiation of hASCs via miR-370-3p/HDAC4 axis.Subsequent in vivo experiments showed the silencing of circ_0003204 increased the bone formation and promoted the expression of osteogenic-related proteins in a mouse bone defect model,while overexpression of circ_0003204 inhibited bone defect repair.Our findings indicated that circ_0003204 might be a promising target to promote the efficacy of hASCs in repairing bone defects.

基于随机森林的语音情感特征选择与分类

针对复杂高维的语音情感特征,选择重要的特征对降低识别模型复杂度以及提高情感识别率具有重要意义。基于Fisher准则和随机森林算法中的平均下降Gini指数对特征重要性评估,提出了一种融合的特征选择方法。该方法首先分别采用Fisher准则和平均下降Gini指数对所有特征进行重要性评估;其次设定某一阈值,各自选择其中较佳的特征进行交集操作;再次依据平均下降Gini指数中重要特征的排列顺序对交集操作后的特征进行重排;最后以语音情感识别率准则确定最佳的特征维度。实验结果表明,融合的特征选择法是有效的,能够提高语音情感的识别率。

上海市崇明地区中老年人群血白细胞计数与血尿酸水平相关性研究

高尿酸血症(hyperuricemia,HUA)指由于嘌呤代谢紊乱和尿酸代谢障碍导致的血液尿酸水平升高。随着生活方式的改变及经济水平的提高,HUA的患病率正在迅速增加[1],已成为全球的公共健康问题。最新荟萃分析显示,中国HUA的总体患病率为13.3%[2],已成为继糖尿病后又一常见代谢性疾病。HUA不仅会引起痛风发作导致关节受损,还使糖尿病、血脂紊乱等代谢性疾病的发生率明显增加,同时也是肾脏损害和心血管事件高发的独立危险因素,早期筛查、诊断、干预尤为重要。

Relationship of ultrasonic shear wave velocity with oncogene and tumor suppressor gene expression in primary liver cancer lesions as well as angiogenesis factor contents

Objective:To discuss the relationship of ultrasonic shear wave velocity (SWV) with oncogene and tumor suppressor gene expression in primary liver cancer lesions as well as angiogenesis factor contents.Methods:100 patients with primary liver cancer who underwent surgical treatment in our hospital between March 2014 and September 2016 were collected as observation group, and 50 healthy subjects who received physical examination in our hospital during the same period were collected as normal control group. The ultrasonic SWV levels of two groups of subjects were measured before the operation, and the observation groups were further divided into high SWV group and low SWV group, 50 cases in each group. Intraoperative tumor tissue samples were kept and fluorescence quantitative PCR was used to determine the mRNA expression of oncogenes and tumor suppressor genes. Enzyme-linked immunosorbent assay was used to determine serum contents of angiogenesis factors in observation group before operation.Results:Hepatic ultrasonic SWV level in observation group was significantly higher than that in normal control group;proto-oncogene CK, Ki67, Gly-3, Survivin and Pokemon mRNA expression in tumor tissue of high SWV group were higher than those of low SWV group while tumor suppressor genes Tg737, p16, p27, PTEN and runx3 mRNA expression were lower than those of low SWV group;serum angiogenesis factors VEGF, MMP-9 and IGF-1R contents were higher than those in low SWV group. Conclusion: The hepatic ultrasonic SWV level increases in patients with primary liver cancer, and the SWV level is directly correlated with oncogene and tumor suppressor gene expression as well as angiogenesis factor contents.

Effects of Long-term Return of Milk Vetch(Astragalus sinicus)on Soil Nutrients and Microorganism Communities in Double-rice Cropping Field

[Objectives]This study was conducted to investigate the effects of milk vetch(Astragalus sinicus)on soil nutrients and microorganisms in paddy fields after returning to the field.[Methods]Three treatments,no fertilization,single application of chemical fertilizers and milk vetch return combined with chemical fertilizers,were set up to determine soil nutrient contents and the quantity of microorganisms,respectively.[Results]The return of milk vetch combined with chemical fertilizers could significantly increase the contents of organic matter and total nitrogen in the paddy soil,while the contents of available potassium and available phosphorus decreased.Milk vetch return combined with chemical fertilizers could significantly increase the quantity of soil microorganisms in the paddy field.[Conclusions]The return of milk vetch can be used as a feasible measure to improve soil fertility.

Value of Zhuang medicine choerospondias axillaris bark for evaluating the expression of PTEN,VEGF in chronic wounds rats

Objective:To investigate the mechanism of treating chronic wounds in rats by using Zhuang medicine choerospondias axillaris bark.Methods: The whole layer skin defection 40 rats were used and randomly divided into 4 groups: normal group, model group, MEBO group, choerospondias group. The normal group and model group were given external deposited normal saline external application. MEBO group used MEBT/MEBO. Choerospondias group was given external deposited choerospondias axillaris bark water decoction external application. Detected cell ultrastructure, PTEN、VEGF mRNA after 12 d.Results: The organelle structure in MEBO group and choerospondias group were restored. In 12 d, PTEN in MEBO group and choerospondias group were lower, VEGF were higher than 1 d (P<0.05). PTEN in MEBO group and choerospondias group were lower, VEGF were higher than model group (P<0.05). MEBO group had no difference with choerospondias group (P>0.05). Conclusion: Choerospondias axillaris bark water decoction could remarkably improve the cell ultrastructure in chronic wounds, regulate the PTEN signal conduction effect, and promote wound healing.

Research on the Reform of Teaching Management Emergency Mechanism in University Based on Big Data

Sudden major public health events once again test the ability of the whole society to deal with emergencies.Universities are no exception.There are many kinds of management work in Colleges and universities,among which teaching management is the most important one,which is also one of the most affected in this epidemic situation.Therefore,in view of the problems of teaching management in Colleges and universities exposed in the epidemic,combined with the characteristics of independent colleges,starting from the aspects of teaching guarantee mechanism,teaching supervision mechanism,teaching process construction,teaching resources construction and so on,the advantages of big data technology,such as large amount of information,easy to communicate and easy to integrate,are fully used to put forward a set of open-minded,perfect mechanism and advanced technology teaching management emergency response mechanism.

基于Fisher准则和Adaboost的语音情感多分类研究

随着社会和科技的快速发展,如何有效识别语音情感已经成为人们关注的一个热点。在众多的分类算法中,Adaboost多分类算法得到了较好的应用效果。该算法将生气、开心、中性、伤心和害怕5种语音情感分为三层,由粗到细,逐层识别。基于柏林情感语音库,将提取的语音情感特征利用Fisher准则选择较佳特征作为实验数据,实验结果表明,将相近情感分在一起训练更有利于提升Adaboost算法的分类性能。此外,在与传统的BP和SVM分类模型比较中,Adaboost多分类算法表现出了优越性。

密歇根神经筛查量表、痛觉触觉温觉检测联合震动感觉阈值诊断糖尿病周围神经病变的价值研究

目的分析密歇根神经筛查量表(MNSI)、痛觉触觉温觉检测联合震动感觉阈值(VPT)对糖尿病周围神经病变(DPN)的诊断价值。方法回顾性选取2018年1—12月在上海交通大学医学院附属新华医院崇明分院住院治疗的2型糖尿病(T2DM)患者500例,其中64例DPN患者纳入DPN组,其余436例纳入非DPN组。比较两组临床资料及MNSI、痛觉触觉温觉检测阈值及VPT检测结果,绘制受试者工作特征(ROC)曲线分析上述检查指标单一及联合诊断DPN的临床价值。结果DPN组MNSI症状问卷评分及MNSI体格检查评分均高于非DPN组[(3.00±1.35)分比(1.69±0.52)分、(1.57±0.50)分比(1.01±0.24)分],触觉、痛觉、温觉减退或消失比例高于非DPN组,且DPN组VPT高于非DPN组[(26.34±5.03)V比(17.97±6.82)V],差异均有统计学意义(P<0.01);单一指标诊断时VPT诊断的曲线下面积(AUC)值最高为0.825,并显著高于触觉、痛觉、温觉(P<0.01);联合诊断时VPT+MNSI的AUC值最高为0.738,诊断DPN的灵敏度、特异度为51.56%、96.10%。结论VPT诊断DPN效能最佳,联合MNSI可进一步提升特异度,但灵敏度下降,值得临床重视。

崇明地区妊娠期妇女糖代谢状况及与妊娠不良结局的相关性研究

目的:通过对新华医院崇明分院妊娠期妇女糖代谢状况的回顾性分析,探讨妊娠期高血糖的危险因素及其与妊娠不良结局的相关性。方法:收集2019年9月至2021年5月在新华医院崇明分院产检并正常分娩的单胎妊娠妇女604例为研究对象,按照血糖情况分为糖耐量正常(NGTG)组和妊娠糖尿病(GDM)组,将血糖超过正常但未达到GDM诊断标准的孕妇归为血糖中间状态(ISGBG)组,分别完成问卷调查、体格检查和相关实验室检测。使用SPSS13.0系统完成统计学分析。结果:604例孕妇中GDM的发生率20.86%(126/604),ISGBG妇女占40.39%(244/604),NGTG占38.74%(234/604)。多因素 logistic回归分析显示,妊娠年龄( OR=1.092, P<0.001)、孕早期三酰甘油( OR=1.625, P=0.001)、孕早期FT 3( OR=1.995, P=0.002)是GDM的独立危险因素。ISGBG组和GDM组的妊娠期高血压发生率、剖宫产率、巨大胎儿生产率、不良妊娠结局总发生率和胎儿出生体重均较NGTG组明显增加( P<0.05或 P<0.01)。 结论:崇明地区GDM的发生率较高,ISGBG的比例更高,因其均导致妊娠不良结局增加,除了重视GDM的早期干预,对于血糖高于正常但未达到GDM诊断标准的孕妇也应加强早期管理。

上海崇明地区中老年人群血红蛋白与糖尿病的相关性研究

目的探讨上海崇明地区中老年人群血红蛋白与糖尿病的相关性。方法采取随机整群抽样法以上海崇明区城桥镇7534名常驻居民为研究对象,完成规范的问卷调查、体格检查和相关实验室检查,血红蛋白浓度采用氰化高铁血红蛋白分光光度法测定。根据1999年世界卫生组织诊断标准以及病史将调查人群分为正常糖代谢组、新诊断糖尿病组和已知糖尿病组,根据世界卫生组织贫血诊断标准将调查人群分为贫血组和非贫血组。采用二元logistic回归模型评估不同血红蛋白水平四分位数间2型糖尿病的发生风险。血红蛋白与临床及实验室等代谢指标间的相关系数采用Spearman相关分析进行评价。结果基线总人群中,正常糖代谢组(n=5579)贫血患病率[275(4.9%)]高于新诊断糖尿病组(n=1203)和已知糖尿病组(n=752)[23(1.9%)及22(2.9%)],已知糖尿病组贫血患病率高于新诊断糖尿病组,差异有统计学意义(P<0.01)。腰围(r=0.257)、臀围(r=0.155)、体质指数(r=0.141)、空腹血糖(r=0.232)、糖负荷后2 h血糖(r=0.140)、糖化血红蛋白(r=0.028)、胰岛素(r=0.036)、稳态模型评估胰岛素抵抗指数(r=0.102)、低密度脂蛋白胆固醇(r=0.056)、总胆固醇(r=0.054)、甘油三酯(r=0.202)均与血红蛋白呈正相关(P均<0.05)。将基线正常糖代谢人群根据血红蛋白进行四分位,3年后随访,血红蛋白第4四分位数组的糖尿病新发率、空腹血糖、糖负荷后2 h血糖均高于第1四分位数组(P<0.01)。在校正其他风险因素后,血红蛋白第4四分位数组其2型糖尿病发生风险较第1四分位数组显著增加,优势比为1.415,95%可信区间为1.087~1.841,P<0.01。结论血红蛋白与糖尿病发生率存在明显正相关,高血红蛋白水平是2型糖尿病的独立危险因素和潜在的预测指标。

GLONASS卫星SNR信号的雪深探测

利用GNSS-MR(Global Navigation Satellite System Multipath Reflectometry)技术反演积雪深度是近年来一种新兴的卫星遥感技术。目前大多数研究仅使用GPS(Global Position System)数据限制了该技术的发展,为了扩展GNSS-MR算法的应用,介绍了基于GNSS-MR算法的雪深反演模型。首先,通过多项式拟合分解GLONASS观测数据获取高精度的信噪比残差序列;然后,利用Lomb-Scargle谱分析法对其进行频谱分析可解算雪深值。选取IGS中心的YEL2站2015年11月到2016年6月共243天的GLONASS卫星L1波段反射信号的SNR数据进行实例分析,并以美国国家气象数据中心提供的加拿大Y-H (Yellowknife Henderson)气象站的实测雪深数据为真值,将反演雪深与实测雪深进行对比验证。所得实验结果如下:(1)与GPS卫星的反演值相比,基于GLONASS-MR(GLONASS Multipath Reflectometry)技术反演积雪深度的精度同样能达到厘米级,RMSE仅3.3 cm,反演值与实测值的空间分布趋势一致且相关性较强,其相关系数R2高达0.969;(2)不同的积雪深度对信噪比的振幅频率与垂直反射距离具有直接影响;(3)对同一卫星而言,信噪比的频谱振幅强度峰值与其对应的反演值存在线性相关;(4)在相同条件下,采用多颗GLONASS卫星数据比单颗GLONASS卫星数据反演雪深的效果明显更优。基于反演的高时间分辨率产品,分析该地区雪深日变化的情况,实验结果表明基于陆基CORS站的GLONASS-MR技术在用于实时、连续的雪深变化监测方面具有良好的潜力和可行性。

Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy

Osteoporosis is a widely distributed disease that may cause complications such as accelerated tooth movement,bone resorption,and tooth loss during orthodontic treatment.Promoting bone formation and reducing bone resorption are strategies for controlling these complications.For several decades,the autophagy inducer lithium chloride(LiCl)has been explored for bipolar.In this study,we investigated the autophagy-promoting effect of LiCl on bone remodeling under osteoporotic conditions during tooth movement.Ovariectomy was used to induce osteoporosis status in vivo.The results showed that LiCl rejuvenated autophagy,decreased apoptosis,and promoted bone formation,thus protecting tooth movement in osteoporotic mice.Furthermore,in vitro experiments showed that LiCl reversed the effects of ovariectomy on bone marrow-derived mesenchymal stem cells(BMSCs)extracted from ovariectomized mice,promoting osteogenesis and suppressing apoptosis by positively regulating autophagy.These findings suggest that LiCl can significantly decrease adverse effects of osteoporosis on bone remodeling,and that it has great potential significance in the field of bone formation during tooth movement in osteoporosis patients.