Main observation and conclusion A general synthesis of chiral 1,3-disubstituted allylsilanes is established through copper(I)-catalyzed asymmetric 1,4-conjugate silylation ofα,β-unsaturated sulfones and subsequent J...Main observation and conclusion A general synthesis of chiral 1,3-disubstituted allylsilanes is established through copper(I)-catalyzed asymmetric 1,4-conjugate silylation ofα,β-unsaturated sulfones and subsequent Julia-Kocienski olefination.By modification of McQuade's NHC ligand,the catalytic asymmetric conjugate silylation with a broad substrate scope is achieved in high enantioselectivity.展开更多
基金We gratefully acknowledge the financial support from the National Natural Science Foundation of China(Nos.21672235,21871287,and 21922114)the Science and Technology Commission of Shanghai Municipality(No.20JC1417100)+2 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000)CAS Key Laboratory of Synthetic Chemistry of Natural SubstancesShanghai Institute of Organic Chemistry.
文摘Main observation and conclusion A general synthesis of chiral 1,3-disubstituted allylsilanes is established through copper(I)-catalyzed asymmetric 1,4-conjugate silylation ofα,β-unsaturated sulfones and subsequent Julia-Kocienski olefination.By modification of McQuade's NHC ligand,the catalytic asymmetric conjugate silylation with a broad substrate scope is achieved in high enantioselectivity.
