Efficacy and safety of ulinastatin in the treatment of septic shock:a systematic review and meta-analysis

Background:Septic shock is a common systemic inflammatory response syndrome for critical patients in the intensive care unit.Ulinastatin is currently used for the treatment of septic shock.Our study sought to evaluate the efficacy and safety of ulinastatin in the treatment of septic shock patients.Methods:Three English databases(Embase,Medline,and Cochrane Library)and four Chinese databases(China National Knowledge Infrastructure,Wanfang data,SinoMed,and VIP)were searched for published randomized controlled trials.Stata 16.0 software was used to conduct the meta-analysis.Results:A total of 48 articles were included(Chinese article 47,1 in English).The results show that the treatment of ulinastatin could reduce mortality(risk ratio=0.63,95%confidence interval(CI)(0.55,0.72)),multiple organ dysfunction syndrome(risk ratio=0.6,95%CI(0.53,0.68)),length of intensive care unit stay(mean difference(MD)=-3.92,95%CI(-4.65,-3.18)),length of hospital stay(MD=-4.39,95%CI(-6.63,-2.15))and decrease Acute Physiology and Chronic Health Evaluation II score(MD=-4.55,95%CI(-5.63,-3.47))and Sequential Organ Failure Assessment score(MD=-2.02,95%CI(-2.59,-1.44))with P<0.001.Moreover,it lowers TNF-α(standardized mean difference(SMD)=-1.78,95%CI(-2.24,-1.32)),Interleukin-6(SMD=-1.17,95%CI(-1.55,-0.8)),C reactive protein(SMD=-1.49,95%CI(-1.99,-0.99)),hypersensitive C-reactive protein(SMD=-1.9,95%CI(-2.87,-0.94))and procalcitonin(SMD=-0.89,95%CI(-1.12,-0.67))levels in the body.Conclusions:Available evidence shows that ulinastatin reduces case mortality rate,multiple organ dysfunction syndrome,length of intensive care unit stay,and length of hospital stay and decreases Acute Physiology and Chronic Health Evaluation II score and Sequential Organ Failure Assessment score.Moreover,it also lowers TNF-α,Interleukin-6,C reactive protein,hypersensitive C-reactive protein,and procalcitonin levels in the body.

A Survey of Approximate Computing:From Arithmetic Units Design to High-Level Applications

Realizing a high-performance and energy-efficient circuit system is one of the critical tasks for circuit designers.Conventional researchers always concentrated on the tradeoffs between the energy and the performance in circuit and system design based on accurate computing.However,as video/image processing and machine learning algorithms are widespread,the technique of approximate computing in these applications has become a hot topic.The errors caused by approximate computing could be tolerated by these applications with specific processing or algorithms,and large improvements in performance or power savings could be achieved with some acceptable loss in final output quality.This paper presents a survey of approximate computing from arithmetic units design to high-level applications,in which we try to give researchers a comprehensive and insightful understanding of approximate computing.We believe that approximate computing will play an important role in the circuit and system design in the future,especially with the rapid development of artificial intelligence algorithms and their related applications.

Search for heavy Majorana neutrinos at future lepton colliders

A nonzero neutrino mass may be a sign of new physics beyond the standard model(SM).To explain the small neutrino mass,we can extend the SM using right-handed Majorana neutrinos in a low-scale seesaw mechanism,and the CP violation effect can be induced due to the CP phase in the interference of heavy Majorana neutrinos.The existence of heavy Majorana neutrinos may lead to lepton number violation processes,which can be used to search for the signals of heavy Majorana neutrinos.In this paper,we focus on the CP violation effect related to two generations of heavy Majorana neutrinos at 15 GeV<m_(N1)<70 GeV in the pair production of W bosons and rare decays.It is valuable to investigate Majorana neutrino production signals and the related CP violation effects in rare W boson decays at future lepton colliders.

Doubly charged Higgs production at future ep colliders

The Higgs sector of the standard model can be extended by introducing an SU(2)_(L) Higgs tripletΔto generate tiny neutrino masses in the framework of the type-Ⅱseesaw mechanism.In this paper,we study the pair production of the introduced Higgs triplet at future e-p colliders.The corresponding production cross sections via the vector boson fusion process at the FCC-ep and ILC■FCC are predicted,where the production of a pair of doubly charged Higgs is found to be dominant and then used to investigate the collider phenomenology of the Higgs triplet.Depending on the size of the Higgs triplet vacuum expectation value,the doubly charged Higgs may decay into a pair of same-sign charged leptons or a pair of same-sign W bosons.To explore the discovery potential of the doubly charged Higgs at future e-p colliders,we discuss these two decay scenarios in detail and show their detection sensitivity based on the mass of the doubly charged Higgs.