Correlation of human epidermal growth factor receptor protein expression and colorectal cancer

AIM:To investigate the correlation between human epidermal growth factor receptor(HER-2) protein expression and colorectal cancer(CRC) using a casecontrol study and meta-analysis.METHODS:Tumor tissue specimens from 162 CRC patients were selected for the case group.Fifty cases were randomly selected,and normal CRC tissue at least 10 cm away from the tumor margins of these cases was used to generate the control group.The expression of the HER-2 protein in the 162 CRC tissue samples and the 50 adjacent normal mucosa tissue samples was detected via immunohistochemistry.The experimental data were analyzed using SPSS 18.0software,and R software version 3.1.0 was utilized for further verification.RESULTS:The expression of HER-2 protein in the 162 CRC tissue samples was significantly higher than in the normal tissue specimens.The data showed that the expression of HER-2 in CRC was related to the Dukes' stage,the depth of invasion and lymph node metastasis.The HER-2-positive patients had lower 3-and 5-year OS rates than the HER-2-negative patients,but there was no significant difference.However,there was a statistically significant difference in the 3- and5-year disease-free survival(DFS) rates of HER-2-positive and HER-2-negative patients.The results of the meta-analysis showed that the expression of HER-2in CRC patients was statistically significantly increased over that of healthy people.The 3-year DFS rate in HER-2-positive patients was markedly lower than that in HER-2-negative patients.CONCLUSION:Down-regulation of HER-2 expression might be a dependable strategy for CRC therapy.

Concurrent alcoholic cirrhosis and malignant peritoneal mesothelioma in a patient:A case report

BACKGROUND Malignant peritoneal mesothelioma(MPM)originates from the mesothelial and subcutaneous cells of the abdominal cavity.Its diagnose is difficult due to its nonspecific and vague symptoms,and it should be differentiated from alcoholic cirrhosis and liver and pancreatic cancers.Misdiagnosis and missed diagnosis can easily occur when MPM presents with other diseases.To the best of our knowledge,no case of MPM concurrent with alcoholic cirrhosis has been reported.CASE SUMMARY A 63-year-old man presented to our hospital with abdominal distension for 20days.He had a history of alcohol consumption for nearly 30 years and no history of special drug use or toxic exposure.After treatment for alcoholic cirrhosis in a community hospital,his symptoms did not improve significantly.The patient underwent exploratory laparotomy and surgical resection.Pathologic examination showed an epithelioid MPM.He was treated with chemotherapy and intraperitoneal hyperthermic perfusion after surgery.Currently,he is in a stable condition and tumor recurrence has not occurred.CONCLUSION Misdiagnosis and missed diagnosis of MPM can easily occur because of its insidious onset.Therefore,there is a need to understand.MPM in clinical practice,make the correct diagnosis,and provide timely and effective treatment.

Submucosal hematoma with a wide range of lesions, severe condition and atypical clinical symptoms: A case report

BACKGROUND Submucosal hematoma(SH)is one of the rare causes of upper gastrointestinal bleeding.As a rare and critical disease in clinical practice,it should be paid more attention to by clinicians to avoid missed diagnosis and misdiagnosis.Most of the esophageal submucosal hematomas have clear causes,including retrosternal pain,dysphagia,etc.Here,we report a rare case of SH extending from the hypopharynx to the lower esophagus caused by oral administration of hirudin and panax notoginseng powder,with atypical clinical manifestation.Such a long submucosal hematoma has rarely been reported.CASE SUMMARY The patient was a 60-year-old male with a history of gastritis,hypertension,coronary heart disease,and coronary stent implantation.The patient developed chest tiredness and heartburn after taking 10 capsules of a homemade mixture of hirudin and notoginseng powder in the previous 2 d.He did not have hematemesis or black stool.Gastroscopy and chest computed tomography confirmed the diagnosis of SH,which ranged from the pharynx to the lower esophagus and was 35-40 cm in length.After the diagnosis was confirmed,we performed active conservative treatment on the patient,and the patient recovered well and remained asymptomatic during the 26-mo follow-up.CONCLUSION SH is rare,and cases with atypical clinical symptoms may lead to misdiagnosis and missed diagnosis.Ignorance of this disease can lead to serious clinical consequences.Conservative therapy is effective and the prognosis is good.