Dienols are important structural motifs in organic molecules,but most of the traditional synthetic methods required multistep prefunctionalization of substrates,leading to stoichiometric waste and low atom economy.Her...Dienols are important structural motifs in organic molecules,but most of the traditional synthetic methods required multistep prefunctionalization of substrates,leading to stoichiometric waste and low atom economy.Herein,we report a redox-neutral coupling of simple 1,3-dienes and aldehydes via nickel and Brønsted acid dual catalysis,providing a highly atom-economical and by-product-free route to various dienols with up to 94%yield and up to 50∶1 EE/EZ ratio.The use of 2-isopropoxyphenol as a Brønsted acid co-catalyst was critical to the reactivity and selectivity.展开更多
基金the National Natural Science Foundation of China(21672107 and 21871145)the Fundamental Research Funds for the Central Universities(Nankai University,63191601)the Tianjin Applied Basic Research Project and Cutting-Edge Technology Research Plan(19JCZDJC37900)for financial support.
文摘Dienols are important structural motifs in organic molecules,but most of the traditional synthetic methods required multistep prefunctionalization of substrates,leading to stoichiometric waste and low atom economy.Herein,we report a redox-neutral coupling of simple 1,3-dienes and aldehydes via nickel and Brønsted acid dual catalysis,providing a highly atom-economical and by-product-free route to various dienols with up to 94%yield and up to 50∶1 EE/EZ ratio.The use of 2-isopropoxyphenol as a Brønsted acid co-catalyst was critical to the reactivity and selectivity.
