期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
肿瘤内细菌调控肿瘤细胞可塑性研究进展与展望
1
作者 钟儒天 余星晨 +2 位作者 杨丰瑞 姚雪彪 刘行 《中国科学技术大学学报》 CAS CSCD 北大核心 2023年第12期1-7,I0001,I0009,共9页
病原微生物与宿主细胞的交流与互作机制是生物医学领域的重要科学问题。随着单细胞分析和多组学研究模式的拓展,该领域迎来了新的科研突破。最新研究表明,肿瘤内细菌通过与肿瘤细胞及肿瘤免疫细胞互作改变肿瘤的演进和可塑性。为此,进... 病原微生物与宿主细胞的交流与互作机制是生物医学领域的重要科学问题。随着单细胞分析和多组学研究模式的拓展,该领域迎来了新的科研突破。最新研究表明,肿瘤内细菌通过与肿瘤细胞及肿瘤免疫细胞互作改变肿瘤的演进和可塑性。为此,进一步解析肿瘤内细菌与宿主细胞之间的相互作用机制有望为靶向干预肿瘤发展与演进提供新的思路。本文综述了肿瘤内细菌与肿瘤细胞可塑性的研究进展,并展望了未来在制定肿瘤的精准治疗和新的靶向策略方面的潜在启示。 展开更多
关键词 肿瘤 微生物 细菌 病原微生物-宿主互作
下载PDF
Probit Normal Correlated Topic Model
2
作者 xingchen yu Ernest Fokoué 《Open Journal of Statistics》 2014年第11期879-888,共10页
The logistic normal distribution has recently been adapted via the transformation of multivariate Gaussian variables to model the topical distribution of documents in the presence of correlations among topics. In this... The logistic normal distribution has recently been adapted via the transformation of multivariate Gaussian variables to model the topical distribution of documents in the presence of correlations among topics. In this paper, we propose a probit normal alternative approach to modelling correlated topical structures. Our use of the probit model in the context of topic discovery is novel, as many authors have so far concentrated solely of the logistic model partly due to the formidable inefficiency of the multinomial probit model even in the case of very small topical spaces. We herein circumvent the inefficiency of multinomial probit estimation by using an adaptation of the diagonal orthant multinomial probit in the topic models context, resulting in the ability of our topic modeling scheme to handle corpuses with a large number of latent topics. An additional and very important benefit of our method lies in the fact that unlike with the logistic normal model whose non-conjugacy leads to the need for sophisticated sampling schemes, our approach exploits the natural conjugacy inherent in the auxiliary formulation of the probit model to achieve greater simplicity. The application of our proposed scheme to a well-known Associated Press corpus not only helps discover a large number of meaningful topics but also reveals the capturing of compellingly intuitive correlations among certain topics. Besides, our proposed approach lends itself to even further scalability thanks to various existing high performance algorithms and architectures capable of handling millions of documents. 展开更多
关键词 TOPIC Model Bayesian Gibbs SAMPLER CUMULATIVE Distribution Function PROBIT LOGIT DIAGONAL Orthant Efficient Sampling Auxiliary Variable Correlation Structure TOPIC Vocabulary Conjugate Dirichlet Gaussian
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部