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新型冠状病毒基因组的演化分析及谱系划分 被引量:1
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作者 唐小鹿 应若晨 +20 位作者 姚欣敏 李广浩 吴长城 汤易雨立 李志达 邝碧姗 伍锋 池昌盛 杜晓满 覃依 高胜寒 胡松年 马俊才 刘天罡 庞星火 王建伟 赵国屏 谭文杰 张亚平 吕雪梅 陆剑 《Science Bulletin》 SCIE EI CSCD 2021年第22期2297-2311,M0004,共16页
新型冠状病毒肺炎(COVID-19,新冠病毒)的流行严重影响了世界经济和人类健康.随着新冠病毒基因组序列的迅速积累,国际上已经检测和发表了成千上万的基因组变异.为了更好地追踪新冠病毒基因组进化轨迹,并实时解析疫情发展进程中的病毒基... 新型冠状病毒肺炎(COVID-19,新冠病毒)的流行严重影响了世界经济和人类健康.随着新冠病毒基因组序列的迅速积累,国际上已经检测和发表了成千上万的基因组变异.为了更好地追踪新冠病毒基因组进化轨迹,并实时解析疫情发展进程中的病毒基因组特征,本研究分析了121618个高质量的病毒基因组.基于参考基因组第8782和28144位点上的单核苷酸变异(SNV),首先将这些病毒基因组划分为L和S两个主要谱系;根据第3037、14408和23403位点上的SNV,进一步将L谱系划分为L1和L2两个主要亚谱系.在此基础上,根据另外201个基因组变异位点,逐级划分出了130个亚谱系(S中37个, L1中35个, L2中58个).该谱系/亚谱系划分系统具有层次结构,反映了主要谱系中的亚谱系之间的亲缘关系.本研究同时建立了一个配套网站(www.covid19evolution.net),不仅方便用户查看亚谱系信息,而且提供了谱系划分工具,用户可以通过上传新冠病毒基因组序列,做谱系类型鉴定.最后,本研究讨论了代偿突变和自然选择在新冠病毒进化过程中可能起到的作用.本研究将增进对新冠病毒基因组时空动态进化的理解. 展开更多
关键词 COVID-19 Evolutionary analysis Compensatory advantageous mutation Adaptive evolution Lineage designation
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Effect of Earlier Vaccination and a Two-Dose Varicella Vaccine Schedule on Varicella Incidence—Beijing Municipality,2007-2018 被引量:2
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作者 Dan Zhao Luodan Suo +3 位作者 Li Lu Jingbin Pan xinghuo pang Wei Yao 《China CDC weekly》 2021年第15期311-315,共5页
Summary What is already known about this topic?The World Health Organization(WHO)varicella vaccines position paper states that countries where varicella is an important public health burden could consider introducing ... Summary What is already known about this topic?The World Health Organization(WHO)varicella vaccines position paper states that countries where varicella is an important public health burden could consider introducing varicella vaccine(VarV)in the routine childhood immunization program(1).VarV has been available for many years in China but is not included in most routine immunization programs in China. 展开更多
关键词 ROUTINE VACCINE VACCINE
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Willingness of the General Public to Receive the COVID-19 Vaccine During a Second-Level Alert——Beijing Municipality,China,May 2020 被引量:1
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作者 Rui Ma Luodan Suo +1 位作者 Li Lu xinghuo pang 《China CDC weekly》 2021年第25期531-537,共7页
Summary What is already known on this topic?Preclinical trials showed the effectiveness of domestic inactivated vaccine candidates for coronavirus disease 2019(COVID-19).However,it is necessary to evaluate the willing... Summary What is already known on this topic?Preclinical trials showed the effectiveness of domestic inactivated vaccine candidates for coronavirus disease 2019(COVID-19).However,it is necessary to evaluate the willingness of the public to receive future domestic vaccines and to understand factors associated with willingness at the early stages of vaccine development. 展开更多
关键词 COV Public SUMMARY
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Perception of the COVID-19 Epidemic and Acceptance of Vaccination Among Healthcare Workers Prior to Vaccine Licensure——Beijing Municipality,China,May-July 2020 被引量:1
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作者 Luodan Suo Rui Ma +8 位作者 Zhongzhan Wang Tian Tang Haihong Wang Fang Liu Jinfeng Tang Xinghui Peng Xue Guo Li Lu xinghuo pang 《China CDC weekly》 2021年第27期569-575,共7页
Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)vaccine development has been progressing,but acceptance of the new vaccines by healthcare workers(HCWs)was not well known prior to a... Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)vaccine development has been progressing,but acceptance of the new vaccines by healthcare workers(HCWs)was not well known prior to approval of COVID-19 vaccines in China.What is added by this report? 展开更多
关键词 VACCINE VACCINE vaccines
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