Epidemiological evidence indicates that major depressive disorder(MDD)may predispose the development and prognosis of breast cancer(BC)in females[1].However,the mechanisms linking these phenotypes are not fully unders...Epidemiological evidence indicates that major depressive disorder(MDD)may predispose the development and prognosis of breast cancer(BC)in females[1].However,the mechanisms linking these phenotypes are not fully understood.Chronic stress,a hallmark of depression,has been underscored to affect anti-tumor immunity,tumor metabolic reprogramming,hormone synthesis in BC[2,3],and increase tumor metastasis[4],but there is a lack of detailed cellular-level characterization of how MDD history affects the tumorigenesis of BC.This study explored the single-cell atlas of multiple tissues from BC patients with and without a history of MDD for characterizing the potential molecular alternations in their tumorigenesis(Figure 1A).展开更多
基金supported by funding from the Zhejiang Provincial Key Research and Development Program(No.2021C03107 to S.H.)the Leading Talent of Scientific and Technological Innovation-“Ten Thousand Talents Program”of Zhejiang Province(No.2021R52016 to S.H.)+1 种基金the National Natural Science Foundation(No.82172770 to P.F.)the Fundamental Research Funds for the Central Universities(226-2022-00193,226-2022-00002).
文摘Epidemiological evidence indicates that major depressive disorder(MDD)may predispose the development and prognosis of breast cancer(BC)in females[1].However,the mechanisms linking these phenotypes are not fully understood.Chronic stress,a hallmark of depression,has been underscored to affect anti-tumor immunity,tumor metabolic reprogramming,hormone synthesis in BC[2,3],and increase tumor metastasis[4],but there is a lack of detailed cellular-level characterization of how MDD history affects the tumorigenesis of BC.This study explored the single-cell atlas of multiple tissues from BC patients with and without a history of MDD for characterizing the potential molecular alternations in their tumorigenesis(Figure 1A).
