The fruit and vegetable agricultural products are related to the livelihood of people. With the advance of agricultural informatization, using software to carry out operation, sale, and inventory management on fruit a...The fruit and vegetable agricultural products are related to the livelihood of people. With the advance of agricultural informatization, using software to carry out operation, sale, and inventory management on fruit and vegetable agricultural products is imperative. Through a lot of market surveys and researches combined with data collection and sorting, I develop the distribution management system of fruit and vegetable agricultural products. The system uses the development tools of C++6.0 and SQL Server 2005, to realize system maintenance, data maintenance, purchase control, sales management, inventory management, expense management, container management, statistical reports and other functional modules. The system can meet informatization management of fruit and vegetable agricultural products in Shanghai farmers' market, improve work efficiency, and accelerate the process of agricultural informatization.展开更多
The combinational density of immobilized functional molecules on biomaterial surfaces directs cell behaviors. However, limited by the low efficiency of traditional low-throughput experimental methods, investigation an...The combinational density of immobilized functional molecules on biomaterial surfaces directs cell behaviors. However, limited by the low efficiency of traditional low-throughput experimental methods, investigation and optimization of the combinational density remain daunting challenges. Herein, we report a high-throughput screening set-up to study biomaterial surface functionalization by integrating photo-controlled thiol-ene surface chemistry and machine learning-based label-free cell identification and statistics. Through such a strategy, a specific surface combinational density of polyethylene glycol (PEG) and arginine-glutamic acid-aspartic acid-valine peptide (REDV) leads to high endothelial cell (EC) selectivity against smooth muscle cell (SMC) was identified. The composition was translated as a coating formula to modify medical nickel-titanium alloy surfaces, which was then proved to improve EC competitiveness and induce endothelialization. This work provided a high-throughput method to investigate behaviors of co-cultured cells on biomaterial surfaces modified with combinatorial functional molecules.展开更多
Intramuscular fat(IMF) is a major meat-quality trait in pigs. The content of IMF is directly associated with the taste and flavor of pork. As a complex trait, there could be multiple genes affecting IMF content in por...Intramuscular fat(IMF) is a major meat-quality trait in pigs. The content of IMF is directly associated with the taste and flavor of pork. As a complex trait, there could be multiple genes affecting IMF content in pork. Genomewide association study is a powerful tool to detect genomic regions associated with phenotypic variations. The objectives of the present study were to identify or refine the positions of genomic regions affecting IMF, and to characterize candidate genes and pathways that may influence this trait. Of note, we identified a significant region in longissium dorsi muscle in a Duroc pig population for IMF content with Porcine SNP60 v2 Bead Chip. This region spans 1.24 Mb on chromosome 8 and had been identified as a quantitative trait locus for IMF in Pietrain, Large White, Landrace, and Leicoma pigs. In this region, eight SNPs were significantly associated with IMF content. Three genes proximal to these significant SNPs were considered candidate genes, including ZDHHC16, LOC102162218 and PCDH7. Our results confirm several previous findings and highlight several genes that may contribute to IMF variation in Duroc pigs.展开更多
Chiral molecules containing sulfonyl and 1,5-diol moieties are useful synthetic blocks for various asymmetric transformations.A protocol has been developed for the enantioselective synthesis of optically active bis(β...Chiral molecules containing sulfonyl and 1,5-diol moieties are useful synthetic blocks for various asymmetric transformations.A protocol has been developed for the enantioselective synthesis of optically active bis(β-hydroxy)sulfones catalyzed by a chiral cationic ruthenium diamine catalyst.A series of bis(β-hydroxy)sulfones have been obtained in excellent yields(up to 99%)with excellent enantioselectivities(up to 99%)as well as good diastereoselectivities(up to 99∶1).展开更多
文摘The fruit and vegetable agricultural products are related to the livelihood of people. With the advance of agricultural informatization, using software to carry out operation, sale, and inventory management on fruit and vegetable agricultural products is imperative. Through a lot of market surveys and researches combined with data collection and sorting, I develop the distribution management system of fruit and vegetable agricultural products. The system uses the development tools of C++6.0 and SQL Server 2005, to realize system maintenance, data maintenance, purchase control, sales management, inventory management, expense management, container management, statistical reports and other functional modules. The system can meet informatization management of fruit and vegetable agricultural products in Shanghai farmers' market, improve work efficiency, and accelerate the process of agricultural informatization.
基金supported by the National Key R&D Program of China(2022YFB3807300)the National Natural Science Foundation of China(52293381,22175152,52103188)+2 种基金the Joint Funds of the Zhejiang Provincial Natural Science Foundation of China and Huadong Medicine(LHDMZ22H300011)the Fundamental Research Funds for the Central Universities(226-2022-00146)the International Research Center for X Polymers,Zhejiang University(130000-171207723/001/010).
文摘The combinational density of immobilized functional molecules on biomaterial surfaces directs cell behaviors. However, limited by the low efficiency of traditional low-throughput experimental methods, investigation and optimization of the combinational density remain daunting challenges. Herein, we report a high-throughput screening set-up to study biomaterial surface functionalization by integrating photo-controlled thiol-ene surface chemistry and machine learning-based label-free cell identification and statistics. Through such a strategy, a specific surface combinational density of polyethylene glycol (PEG) and arginine-glutamic acid-aspartic acid-valine peptide (REDV) leads to high endothelial cell (EC) selectivity against smooth muscle cell (SMC) was identified. The composition was translated as a coating formula to modify medical nickel-titanium alloy surfaces, which was then proved to improve EC competitiveness and induce endothelialization. This work provided a high-throughput method to investigate behaviors of co-cultured cells on biomaterial surfaces modified with combinatorial functional molecules.
基金supported by the National Natural Science Foundation of China (51902098, 51972105, 51525202, and 61574054)the Hunan Provincial Natural Science Foundation (2018RS3051).
基金supported by the National Natural Science Foundation of China (U19A2090, 51902098, 51972105, 51525202, and 61574054)the Hunan Provincial Natural Science Foundation (2018RS3051)。
基金financial support from the National Natural Science Foundation of China (31601912)the Natural Science Foundation of Guangdong Province (2016A030310447)the Applied Science and Technology Research and Development of Special Funds of Guangdong Province (2015B020231010)
文摘Intramuscular fat(IMF) is a major meat-quality trait in pigs. The content of IMF is directly associated with the taste and flavor of pork. As a complex trait, there could be multiple genes affecting IMF content in pork. Genomewide association study is a powerful tool to detect genomic regions associated with phenotypic variations. The objectives of the present study were to identify or refine the positions of genomic regions affecting IMF, and to characterize candidate genes and pathways that may influence this trait. Of note, we identified a significant region in longissium dorsi muscle in a Duroc pig population for IMF content with Porcine SNP60 v2 Bead Chip. This region spans 1.24 Mb on chromosome 8 and had been identified as a quantitative trait locus for IMF in Pietrain, Large White, Landrace, and Leicoma pigs. In this region, eight SNPs were significantly associated with IMF content. Three genes proximal to these significant SNPs were considered candidate genes, including ZDHHC16, LOC102162218 and PCDH7. Our results confirm several previous findings and highlight several genes that may contribute to IMF variation in Duroc pigs.
基金the National Natural Science Foundation of China(No.21272166)the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions(No.13KJA150004)the Program for New Century Excellent Talents in University(No.NCET-12-0743).
文摘Chiral molecules containing sulfonyl and 1,5-diol moieties are useful synthetic blocks for various asymmetric transformations.A protocol has been developed for the enantioselective synthesis of optically active bis(β-hydroxy)sulfones catalyzed by a chiral cationic ruthenium diamine catalyst.A series of bis(β-hydroxy)sulfones have been obtained in excellent yields(up to 99%)with excellent enantioselectivities(up to 99%)as well as good diastereoselectivities(up to 99∶1).
