Nanovesicles have been demonstrated to be the key agents in therapeutic encapsulations for drug delivery and diagnostic area,and the effectiveness and efficiency of these applications strongly depend on the mechanical...Nanovesicles have been demonstrated to be the key agents in therapeutic encapsulations for drug delivery and diagnostic area,and the effectiveness and efficiency of these applications strongly depend on the mechanical properties of nanovesicles.Based on the Helfrich membrane theory,a theoretical investigation is conducted to explore the mechanical behaviors of pressurized elastic fluid nanovesicles during the indentation by a rigid cylindrical indenter.The effects of osmotic pressure,membrane bending rigidity,energy of adhesion bet ween the vesicle and substrate on the mechanical responses of the vesicle to the indentation are analyzed.It is found that the osmotic pressure dominates the mechanical behaviors of strongly pressurized nanovesicles as well as the effective vesicle stiffness and Young's modulus.Our results may have important implications on regulating the mechanical behaviors of inter-and intracellular nanovesicles which are crucial for particle-based drug delivery systems.展开更多
Correction To:Acta Mechanica Solida Sinica https://doi.org/10.1007/s10338-019-00107-5 Unfortunately due to a typesetting mistake in the caption of Fig.1,fourth line,仏has been displayed wrongly as/2-The original artic...Correction To:Acta Mechanica Solida Sinica https://doi.org/10.1007/s10338-019-00107-5 Unfortunately due to a typesetting mistake in the caption of Fig.1,fourth line,仏has been displayed wrongly as/2-The original article has been corrected.展开更多
基金Financial support for this work was provided by the National Natural Science Foundation of China(Grant Nos.11872005 and 11521202).
文摘Nanovesicles have been demonstrated to be the key agents in therapeutic encapsulations for drug delivery and diagnostic area,and the effectiveness and efficiency of these applications strongly depend on the mechanical properties of nanovesicles.Based on the Helfrich membrane theory,a theoretical investigation is conducted to explore the mechanical behaviors of pressurized elastic fluid nanovesicles during the indentation by a rigid cylindrical indenter.The effects of osmotic pressure,membrane bending rigidity,energy of adhesion bet ween the vesicle and substrate on the mechanical responses of the vesicle to the indentation are analyzed.It is found that the osmotic pressure dominates the mechanical behaviors of strongly pressurized nanovesicles as well as the effective vesicle stiffness and Young's modulus.Our results may have important implications on regulating the mechanical behaviors of inter-and intracellular nanovesicles which are crucial for particle-based drug delivery systems.
文摘Correction To:Acta Mechanica Solida Sinica https://doi.org/10.1007/s10338-019-00107-5 Unfortunately due to a typesetting mistake in the caption of Fig.1,fourth line,仏has been displayed wrongly as/2-The original article has been corrected.
