The attitude control problem of the kinetic kill vehicle is studied in this work. A new mathematical model of the kinetic kill vehicle is proposed, the linear quadratic regulator technique is used to design the optima...The attitude control problem of the kinetic kill vehicle is studied in this work. A new mathematical model of the kinetic kill vehicle is proposed, the linear quadratic regulator technique is used to design the optimal attitude controller, and the pulse-width pulse-frequency modulator is used to shape the continuous control command to pulse or on-off signals to meet the requirements of the reaction thrusters. The methods to select the appropriate parameters of pulse-width pulse-frequency are presented in detail. Numerical simulations show that the performance of the LQR/PWPF approach can achieve good control performance such as pseudo-linear operation, high accuracy, and fast enough tracking speed.展开更多
NBI fast ion losses in the presence of the toroidal field ripple on EAST have been investigated by using the orbit code GYCAVA and the NBI code TGCO.The ripple effect was included in the upgraded version of the GYCAVA...NBI fast ion losses in the presence of the toroidal field ripple on EAST have been investigated by using the orbit code GYCAVA and the NBI code TGCO.The ripple effect was included in the upgraded version of the GYCAVA code.It is found that loss regions of NBI fast ions are mainly on the low field side near the edge in the presence of ripple.For co-current NBIs,the synergy effect of ripple and Coulomb collision on fast ion losses is dominant,and fast trapped ions located on the low field side are easily lost.The ripple well loss and the ripple stochastic loss of fast ions have been identified from the heat loads of co-current NBI fast ions.The ripple stochastic loss and the collisioninduced loss are much larger than the ripple well loss.Heat loads of lost fast ions are mainly localized on the right side of the radio frequency wave antennas from the inside view toward the first wall.For counter-current NBIs,the first orbit loss due to the magnetic drift is the dominant loss channel.In addition,fast ion loss fraction with ripple and collision for each NBI linearly increases with the effective charge number,which is related to the pitch angle scattering effect.展开更多
We review recent work on narrowband orthogonally polarized optical RF single sideband generators as well as dualchannel equalization,both based on high-Q integrated ring resonators.The devices operate in the optical t...We review recent work on narrowband orthogonally polarized optical RF single sideband generators as well as dualchannel equalization,both based on high-Q integrated ring resonators.The devices operate in the optical telecommunications C-band and enable RF operation over a range of either fixed or thermally tuneable frequencies.They operate via TE/TM mode birefringence in the resonator.We achieve a very large dynamic tuning range of over 55 dB for both the optical carrier-to-sideband ratio and the dual-channel RF equalization for both the fixed and tunable devices.展开更多
Simulations of first-orbit losses of neutral beam injection(NBI)fast ions in the EAST tokamak have been studied in detail by using the orbit-following code GYCAVA and the NBI code TGCO.Beam ion losses with the wall bo...Simulations of first-orbit losses of neutral beam injection(NBI)fast ions in the EAST tokamak have been studied in detail by using the orbit-following code GYCAVA and the NBI code TGCO.Beam ion losses with the wall boundary are smaller than those with the last closed flux surface boundary.In contrast to heat loads on the wall without radio frequency wave(RFW)antennas,heat loads on the wall with RFW antennas are distributed more locally near the RFW antennas.The direction of the toroidal magnetic field dramatically affects the final positions of lost fast ions,which is related to the magnetic drift.The numerical results on heat loads of beam ions corresponding to different toroidal magnetic fields are qualitatively consistent with the experimental results.Beam ion losses increase with the beam energy for the co-current NBIs and the counter-perpendicular NBI.We have studied the behavior of fast ions produced by a small section neutral beam(beamlet)by using the numerical tool NBIT.The distributions of the loss fraction of beamlet fast ions peaked near the edge of the beam section for the counter-current NBIs,and they are related to the injection angle.This indicates that the first-orbit losses can be reduced by changing the shape of beam cross section.展开更多
We review recent work on broadband RF channelizers based on integrated optical frequency Kerr micro-combs combined with passive micro-ring resonator filters,with microcombs having channel spacings of 200 and 49 GHz.Th...We review recent work on broadband RF channelizers based on integrated optical frequency Kerr micro-combs combined with passive micro-ring resonator filters,with microcombs having channel spacings of 200 and 49 GHz.This approach to realizing RF channelizers offers reduced complexity,size,and potential cost for a wide range of applications to microwave signal detection.展开更多
We demonstrate significantly improved performance of a microwave true time delay line based on an integrated optical frequency comb source. The broadband micro-comb(over 100 nm wide) features a record low free spectra...We demonstrate significantly improved performance of a microwave true time delay line based on an integrated optical frequency comb source. The broadband micro-comb(over 100 nm wide) features a record low free spectral range(FSR) of 49 GHz, resulting in an unprecedented record high channel number(81 over the C band)—the highest number of channels for an integrated comb source used for microwave signal processing. We theoretically analyze the performance of a phased array antenna and show that this large channel count results in a high angular resolution and wide beam-steering tunable range. This demonstrates the feasibility of our approach as a competitive solution toward implementing integrated photonic true time delays in radar and communications systems.展开更多
Despite recent progress in hepatitis treatment,there have been no significant advances in the development of liver cancer vaccines in recent years.In this study,we investigated the regulatory effect and potential mech...Despite recent progress in hepatitis treatment,there have been no significant advances in the development of liver cancer vaccines in recent years.In this study,we investigated the regulatory effect and potential mechanism of hepatocyte growth factor receptor(MET,also known as HGFR)on tumor vaccinations for liver cancer in mice.Herein,we demonstrate that MET expression is significantly associated with the immunogenicity of liver cancer in mice and humans,and that MET depletion dramatically enhances the protective efficacy of chemotherapy-based anti-liver cancer vaccination.Mechanistically,MET repressed liver cancer immunogenicity independent of the traditional PI3K–AKT cascade,and MET interacted with vacuolar ATP synthase(V-ATPase)and mediated the activation of mammalian target of rapamycin(MTOR),thus suppressing liver cancer immunogenicity.The efficacy of chemotherapy-based liver cancer vaccination was markedly enhanced by targeting the MET–V-ATPase–MTOR axis,highlighting a translational strategy for identifying MET-associated drug candidates for cancer prevention.展开更多
文摘The attitude control problem of the kinetic kill vehicle is studied in this work. A new mathematical model of the kinetic kill vehicle is proposed, the linear quadratic regulator technique is used to design the optimal attitude controller, and the pulse-width pulse-frequency modulator is used to shape the continuous control command to pulse or on-off signals to meet the requirements of the reaction thrusters. The methods to select the appropriate parameters of pulse-width pulse-frequency are presented in detail. Numerical simulations show that the performance of the LQR/PWPF approach can achieve good control performance such as pseudo-linear operation, high accuracy, and fast enough tracking speed.
基金supported by National Natural Science Foundation of China(No.11775265)。
文摘NBI fast ion losses in the presence of the toroidal field ripple on EAST have been investigated by using the orbit code GYCAVA and the NBI code TGCO.The ripple effect was included in the upgraded version of the GYCAVA code.It is found that loss regions of NBI fast ions are mainly on the low field side near the edge in the presence of ripple.For co-current NBIs,the synergy effect of ripple and Coulomb collision on fast ion losses is dominant,and fast trapped ions located on the low field side are easily lost.The ripple well loss and the ripple stochastic loss of fast ions have been identified from the heat loads of co-current NBI fast ions.The ripple stochastic loss and the collisioninduced loss are much larger than the ripple well loss.Heat loads of lost fast ions are mainly localized on the right side of the radio frequency wave antennas from the inside view toward the first wall.For counter-current NBIs,the first orbit loss due to the magnetic drift is the dominant loss channel.In addition,fast ion loss fraction with ripple and collision for each NBI linearly increases with the effective charge number,which is related to the pitch angle scattering effect.
文摘We review recent work on narrowband orthogonally polarized optical RF single sideband generators as well as dualchannel equalization,both based on high-Q integrated ring resonators.The devices operate in the optical telecommunications C-band and enable RF operation over a range of either fixed or thermally tuneable frequencies.They operate via TE/TM mode birefringence in the resonator.We achieve a very large dynamic tuning range of over 55 dB for both the optical carrier-to-sideband ratio and the dual-channel RF equalization for both the fixed and tunable devices.
基金the support of the EAST teamsupported by National Natural Science Foundation of China (No. 11775265)
文摘Simulations of first-orbit losses of neutral beam injection(NBI)fast ions in the EAST tokamak have been studied in detail by using the orbit-following code GYCAVA and the NBI code TGCO.Beam ion losses with the wall boundary are smaller than those with the last closed flux surface boundary.In contrast to heat loads on the wall without radio frequency wave(RFW)antennas,heat loads on the wall with RFW antennas are distributed more locally near the RFW antennas.The direction of the toroidal magnetic field dramatically affects the final positions of lost fast ions,which is related to the magnetic drift.The numerical results on heat loads of beam ions corresponding to different toroidal magnetic fields are qualitatively consistent with the experimental results.Beam ion losses increase with the beam energy for the co-current NBIs and the counter-perpendicular NBI.We have studied the behavior of fast ions produced by a small section neutral beam(beamlet)by using the numerical tool NBIT.The distributions of the loss fraction of beamlet fast ions peaked near the edge of the beam section for the counter-current NBIs,and they are related to the injection angle.This indicates that the first-orbit losses can be reduced by changing the shape of beam cross section.
文摘We review recent work on broadband RF channelizers based on integrated optical frequency Kerr micro-combs combined with passive micro-ring resonator filters,with microcombs having channel spacings of 200 and 49 GHz.This approach to realizing RF channelizers offers reduced complexity,size,and potential cost for a wide range of applications to microwave signal detection.
基金Australian Research Council(ARC)Discovery Projects Program(DP150104327)Strategic,Discovery and Acceleration Grants Schemes of Natural Sciences and Engineering Research Council of Canada(NSERC)+4 种基金MESI PSR-SIIRI Initiative in QuebecCanada Research Chairs ProgramITMO Fellowship and Professorship Program of the Government of the Russian Federation(074-U 01)1000 Talents Sichuan Program in ChinaStrategic Priority Research Program of the Chinese Academy of Sciences(CAS)(XDB24030000)
文摘We demonstrate significantly improved performance of a microwave true time delay line based on an integrated optical frequency comb source. The broadband micro-comb(over 100 nm wide) features a record low free spectral range(FSR) of 49 GHz, resulting in an unprecedented record high channel number(81 over the C band)—the highest number of channels for an integrated comb source used for microwave signal processing. We theoretically analyze the performance of a phased array antenna and show that this large channel count results in a high angular resolution and wide beam-steering tunable range. This demonstrates the feasibility of our approach as a competitive solution toward implementing integrated photonic true time delays in radar and communications systems.
基金supported by grants from the National Natural Science Foundation of China(31970696 and 81502975 to X.H.,and 81830089 to T.L.)the National Key Research and Development Program(2019YFC1316000 to T.L.)+2 种基金the China Postdoctoral Science Foundation(2016T90413 and 2015M581693 to X.H.)SEU-Alphamab Joint Center(SA2015001 to X.H.)Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents(to X.B.).
文摘Despite recent progress in hepatitis treatment,there have been no significant advances in the development of liver cancer vaccines in recent years.In this study,we investigated the regulatory effect and potential mechanism of hepatocyte growth factor receptor(MET,also known as HGFR)on tumor vaccinations for liver cancer in mice.Herein,we demonstrate that MET expression is significantly associated with the immunogenicity of liver cancer in mice and humans,and that MET depletion dramatically enhances the protective efficacy of chemotherapy-based anti-liver cancer vaccination.Mechanistically,MET repressed liver cancer immunogenicity independent of the traditional PI3K–AKT cascade,and MET interacted with vacuolar ATP synthase(V-ATPase)and mediated the activation of mammalian target of rapamycin(MTOR),thus suppressing liver cancer immunogenicity.The efficacy of chemotherapy-based liver cancer vaccination was markedly enhanced by targeting the MET–V-ATPase–MTOR axis,highlighting a translational strategy for identifying MET-associated drug candidates for cancer prevention.