研究型分析化学综合实验教学模式探究——以“海藻酸盐微胶囊的制备、药物包封及缓控释分析实验”为例

“海藻酸盐微胶囊的制备、药物包封及缓控释分析实验”是II型分析化学实验中非常典型的一个研究型实验,它涵盖了微胶囊形成原理探究、实验条件设计、微胶囊性能表征等科研基本能力的训练。将海藻酸钠与亚甲基蓝混合溶液分别滴加至3%CaCl2溶液和1%壳聚糖溶液中,从而制备出两种不同性能的微胶囊。通过分光光度法测得不同时间溶液的浓度,从而得到缓释曲线,并对两种胶囊的缓释性进行对比分析。后续探究实验采用一步法和两步法制备微胶囊,将两种体系的优点结合起来,得到缓释性和稳定性均较好的微胶囊。

聚乙二醇-硫酸铵-亚硝基R盐体系用于钴(Ⅱ)的分离

在pH=5缓冲溶液条件下,对仅有Co^(2+)、仅有Ni^(2+)、Co^(2+)与Ni^(2+)混合三种情况下Co^(2+)的萃取率进行了探究。结果显示单独萃取Co^(2+)时萃取率高达75.47%;然而对于混合溶液,萃取率较单独萃取Co^(2+)明显下降。通过系列对比实验发现Ni^(2+)的存在对Co^(2+)的分光光度测量造成了干扰。因此,在综合性实验中我们利用分光光度法针对Co^(2+)的萃取率进行分析,以及对可能影响萃取率的因素——pH、萃取时间、萃取次数进行了探究,寻找最佳实验条件,提高萃取率。

Distributed Privacy-Preserving Fusion Estimation Using Homomorphic Encryption

The privacy-preserving problem for distributed fusion estimation scheme is concerned in this paper.When legitimate user wants to obtain consistent information from multiple sensors,it always employs a fusion center(FC)to gather local data and compute distributed fusion estimates(DFEs).Due to the existence of potential eavesdropper,the data exchanged among sensors,FC and user imperatively require privacy preservation.Hence,we propose a distributed confidentiality fusion structure against eavesdropper by using Paillier homomorphic encryption approach.In this case,FC cannot acquire real values of local state estimates,while it only helps calculate encrypted DFEs.Then,the legitimate user can successfully obtain the true values of DFEs according to the encrypted information and secret keys,which is based on the homomorphism of encryption.Finally,an illustrative example is provided to verify the effectiveness of the proposed methods.

Chemical constituents,pharmacological activities and quality evaluation methods of genus Hippocampus:A comprehensive review

The genus Hippocampus is a multi-origin animal species with high medicinal and healthcare values.About 57 species of Hippocampus spread worldwide,of which about 14 species can be used as medicine,showing anti-oxidation,anti-inflammation,anti-depressant,anti-hypertension,anti-prostatic hyperplasia,antivirus,anti-apoptotic,antifatigue,and so on.And those pharmacological effects are mainly related to their active ingredients,including amino acids,abundant proteins(peptides and oligopeptides),fatty acids,nucleosides,steroids,and other small molecular compounds.The main means of authentication of Hippocampus species are morphological identification,microscopic identification,thin layer chromatography method,fingerprint method and genomics method.This review will provide useful insight for exploration,further study and precise medication of Hippocampus in the future.

Catalysis and deactivation of montmorillonite K10 in the aryl O-glycosylation of glycosyl trichloroacetoimidates

The catalysis of montmorillonite K10(MK10)for aryl O-glycosylation of glycosyl trichloroacetimidates was investigated.It was found that the catalyst MK10 is deactivated gradually in the recycle glycosylation.The fresh and the deactivated catalysts were characterized by X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),Thermogravimetric analysis(TGA),and N_(2)adsorption-desorption.The results show that the eliminated trichloroacetamide molecule deposits on the MK10,which blocks and poisons the active sites,resulting in the deactivation of the catalyst.The regeneration of the deactivated MK10 by calcination was studied preliminarily.