The coronavirus disease 2019(COVID-19)pandemic had a devastating impact on human society.Beginning with genome surveillance of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the development of omics techn...The coronavirus disease 2019(COVID-19)pandemic had a devastating impact on human society.Beginning with genome surveillance of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the development of omics technologies brought a clearer understanding of the complex SARS-CoV-2 and COVID-19.Here,we reviewed how omics,including genomics,proteomics,single-cell multi-omics,and clinical phenomics,play roles in answering biological and clinical questions about COVID-19.Large-scale sequencing and advanced analysis methods facilitate COVID-19 discovery from virus evolution and severity risk prediction to potential treatment identification.Omics would indicate precise and globalized prevention and medicine for the COVID-19 pandemic under the utilization of big data capability and phenotypes refinement.Furthermore,decoding the evolution rule of SARS-CoV-2 by deep learning models is promising to forecast new variants and achieve more precise data to predict future pandemics and prevent them on time.展开更多
Dear Editor,Major mood disorders,which primarily include bipolar disorder(BD)and major depressive disorder(MDD),are among the most common psychiatric disorders and are recognized as leading causes of morbidity worldwi...Dear Editor,Major mood disorders,which primarily include bipolar disorder(BD)and major depressive disorder(MDD),are among the most common psychiatric disorders and are recognized as leading causes of morbidity worldwide.Family,twin and adoption studies have consistently indicated moderate-to-strong genetic contribu-tions to the risk of major mood disorders.1 Genetic association and genome-wide association studies(GWAS)suggest that there is some degree of overlap for some specific disorders but also specific genetic diversity.2 DAOA(D-amino acid oxidase activator),a gene located on human chromosome 13q33.2,plays a crucial role in the central nervous system through binding with DAO(encoding D-amino acid oxidase).Convergent lines of biological evidence suggest that DAOA is an attractive candidate gene for major mood disorders.展开更多
基金We thank Professor S.Y.Liu for her revision suggestions for the article’s first draft.We acknowledge support from the CAS Research Fund,Grant No.XDB38050200the Self-supporting Program of Guangzhou Laboratory,Grant No.SRPG22-001 and SRPG22-007.
文摘The coronavirus disease 2019(COVID-19)pandemic had a devastating impact on human society.Beginning with genome surveillance of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the development of omics technologies brought a clearer understanding of the complex SARS-CoV-2 and COVID-19.Here,we reviewed how omics,including genomics,proteomics,single-cell multi-omics,and clinical phenomics,play roles in answering biological and clinical questions about COVID-19.Large-scale sequencing and advanced analysis methods facilitate COVID-19 discovery from virus evolution and severity risk prediction to potential treatment identification.Omics would indicate precise and globalized prevention and medicine for the COVID-19 pandemic under the utilization of big data capability and phenotypes refinement.Furthermore,decoding the evolution rule of SARS-CoV-2 by deep learning models is promising to forecast new variants and achieve more precise data to predict future pandemics and prevent them on time.
基金This work was supported by the Application and Basic Research Program from the Science and Technology Department of Sichuan Province,China(No.2016JY0113)the Key R&D Projects of Sichuan Province,China(No.2018SZ0061)the Fundamental Research Funds for the Central Universities of China(No.2682016CX099 and No.2682018CX38).
文摘Dear Editor,Major mood disorders,which primarily include bipolar disorder(BD)and major depressive disorder(MDD),are among the most common psychiatric disorders and are recognized as leading causes of morbidity worldwide.Family,twin and adoption studies have consistently indicated moderate-to-strong genetic contribu-tions to the risk of major mood disorders.1 Genetic association and genome-wide association studies(GWAS)suggest that there is some degree of overlap for some specific disorders but also specific genetic diversity.2 DAOA(D-amino acid oxidase activator),a gene located on human chromosome 13q33.2,plays a crucial role in the central nervous system through binding with DAO(encoding D-amino acid oxidase).Convergent lines of biological evidence suggest that DAOA is an attractive candidate gene for major mood disorders.
