In the treatment of brachial plexus injury, nerves that are functionally less important are transferred onto the distal ends of damaged crucial nerves to help recover neuromuscular function in the target region. For e...In the treatment of brachial plexus injury, nerves that are functionally less important are transferred onto the distal ends of damaged crucial nerves to help recover neuromuscular function in the target region. For example, intercostal nerves are transferred onto axillary nerves, and accessory nerves are transferred onto suprascapular nerves, the phrenic nerve is transferred onto the musculocutaneous nerves, and the contralateral C7 nerve is transferred onto the median or radial nerves. Nerve transfer has become a major method for reconstructing the brachial plexus after avulsion injury. Many experiments have shown that nerve transfers for treatment of brachial plexus injury can help reconstruct cerebral cortical function and increase cortical plasticity. In this review article, we summarize the recent progress in the use of diverse nerve transfer methods for the repair of brachial plexus injury, and we discuss the impact of nerve transfer on cerebral cortical plasticity after brachial plexus injury.展开更多
Efficient catalytic oxidation of ethylbenzene to acetophenone was realized using the catalytic system of cobalt zeolitic imidazolate framework ZIF-67/N-hydroxyphthalimide (NHPI) under mild conditions. 95.2% conversi...Efficient catalytic oxidation of ethylbenzene to acetophenone was realized using the catalytic system of cobalt zeolitic imidazolate framework ZIF-67/N-hydroxyphthalimide (NHPI) under mild conditions. 95.2% conversion of ethylbenzene with 90.3% selectivity to acetophenone could be obtained at 373 K under 0.3 MPa 02 for 9 h. The results show that there exists synergetic effect between ZIF-67 and NHPI. 1-Phenylethyl hydroperoxide (PEHP) was generated via a radical process involving the hydrogen abstraction from ethylbenzene by phthalimide N-oxyl, and subsequently effectively decomposed to acetophenone by ZIF-67.展开更多
Intensive daytime and nighttime sampling was carried out from 23 Oct to 31 Dec 2008 to investigate the occurrence of nitrated polycyclic aromatic hydrocarbons (NPAHs) in PM1o at a roadside site in Xiamen, China. At ...Intensive daytime and nighttime sampling was carried out from 23 Oct to 31 Dec 2008 to investigate the occurrence of nitrated polycyclic aromatic hydrocarbons (NPAHs) in PM1o at a roadside site in Xiamen, China. At the same time, six PMt0 samples were collected from a nearby roadway tunnel for comparison. Six NPAHs, namely 9-nitroanthracene, 2- and 3-nitrofluoranthene, 1- nitropyrene, 7-nitrobenz[a]anthracene, and 6-nitrobenzo[a]pyrene, were identified and quantified using GC/MS in negative ion chemical ionization mode. The average total concentration of six NPAHs (~NPAHs) in the cold season (26 Nov-31 Dec) was 2.3 (daytime) and 9.9 (nighttime) times higher than those in the warm season. Significant statistical difference (p 〈 0.01, 2-tailed) of ∑NPAHs between daytime and nighttime was found during both the warm and cold seasons. NPAHs were significantly positively correlated with their parent PAHs and nitrogen dioxide but negatively correlated with ambient temperature. The ratio of 2 + 3-nitrofluoranthene to 1- nitropyrene exhibited a similar diurnal pattern as ZNPAHs and was generally greater than 5, indicating the importance of secondary atmospheric formation. The diurnal variations of NPAHs were all influenced by the diurnal variations of PAHs, nitrogen dioxide, sunlight, and temperature. The daily inhalable exposure to the six NPAHs in the tunnel was much higher than the roadside values in the warm season but only slightly higher than those in the cold season.展开更多
Fe-based composite coatings were fabricated on 5 CrNiMo die steel by laser beam melting a precursor mixture of ferrotitanium,ferrochromium,ferromolybdenum,B4 C and Y2 O3 powders.Micro structure and properties of the c...Fe-based composite coatings were fabricated on 5 CrNiMo die steel by laser beam melting a precursor mixture of ferrotitanium,ferrochromium,ferromolybdenum,B4 C and Y2 O3 powders.Micro structure and properties of the coatings were studied by X-ray diffraction(XRD),scanning electron microscopy(SEM),energy-dispersive spectrometer(EDS),resistance furnace and high-temperature tribometer.The results show that(Ti,Mo)C particles with flower-like and(Ti,Mo)B2 with block-like shapes are in situ formed during laser cladding.Volume faction of multiple ceramic particles increases with the increasing of Y2 O3.The cumulative oxidation mass of the coating with 2 wt% Y2 O3 is decreased by one-third than that of the coating without Y2 O3.The oxidation layer of the coating with Y2 O3 is getting smooth.Meanwhile,high temperature wear volume loss of the coating with 2 wt% Y2 O3 is about 40% that of the coating without Y2 O3.The coating with 2 wt% Y2 O3 shows a smoother wear scar and few flat grooves are observed after high temperature wear test.展开更多
Background Intravenous recombinant tissue plasminogen activator(r-tPA)and urokinase(UK)are both recommended for the treatment of acute ischaemic stroke(AIS)in China,but with few comparative outcome data being availabl...Background Intravenous recombinant tissue plasminogen activator(r-tPA)and urokinase(UK)are both recommended for the treatment of acute ischaemic stroke(AIS)in China,but with few comparative outcome data being available.We aimed to compare the outcomes of these two thrombolytic agents for the treatment of patients within 4.5 hours of onset of AIS in routine clinical practice in China.Methods A pre-planned,prospective,nationwide,multicentre,real-world registry of consecutive patients with AIS(age≥18 years)who received r-tPA or UK within 4.5 hours of symptom onset according to local decision-making and guideline recommendations during 2017-2019.The primary effectiveness outcome was the proportion of patients with an excellent functional outcome(defined by modified Rankin scale scores 0 to 1)at 90 days.The key safety endpoint was symptomatic intracranial haemorrhage according to standard definitions.Multivariable logistic regression was used for comparative analysis,with adjustment according to propensity scores to ensure balance in baseline characteristics.Results Overall,4130 patients with AIS were registered but 320 had incomplete or missing data,leaving 3810 with available data for analysis of whom 2666 received r-tPA(median dose 0.88(IQR 0.78-0.90)mg/kg)and 1144 received UK(1.71(1.43-2.00)×104 international unit per kilogram).There were several significant intergroup differences in patient characteristics:r-tPA patients were more educated,had less history of stroke,lower systolic blood pressure,greater neurological impairment and shorter treatment times from symptom onset than UK patients.However,in adjusted analysis,the frequency of excellent outcome(OR 1.18,95%CI 1.00 to 1.40,p=0.052)and symptomatic intracranial haemorrhage(OR 0.70,95%CI 0.33 to 1.47,p=0.344)were similar between groups.Conclusions UK may be as effective and carry a similar safety profile as r-tPA in treating mild to moderate AIS within guidelines in China.Registration http://www.clinicaltrials.gov.unique identifier:NCT02854592.展开更多
Background A recent study shows that dual antiplatelet therapy with clopidogrel plus aspirin is superior to aspirin monotherapy for minor stroke,which is defined as a National Institutes of Health Stroke Scale(NIHSS)s...Background A recent study shows that dual antiplatelet therapy with clopidogrel plus aspirin is superior to aspirin monotherapy for minor stroke,which is defined as a National Institutes of Health Stroke Scale(NIHSS)score of≤3.However,acute mild-moderate ischaemic stroke(4≤NIHSS≤10)still needs aggressive antiplatelet intervention to prevent deterioration and recurrence of stroke.The efficacy and safety of dual antiplatelet therapy versus aspirin monotherapy in the population are not clear.A multicentre clinical trial is designed to evaluate the efficacy and safety of clopidogrel plus aspirin therapy versus aspirin monotherapy within 48 hours of symptom onset of mild-moderate ischaemic stroke.Methods/Design The study is a randomised,open-label,multicentre,prospective trial with a target enrolment of 2700 patients from 60 centres in Northeast China.A treatment allocation identification number to each enrolled patient will be provided by a random number generator.The follow-up time for the clopidogrel plus aspirin and aspirin monotherapy groups is 90 days.The primary efficacy endpoint is a stroke progression event,which is defined as≥4 point increase in the NIHSS score in 48 hours.The second efficacy endpoints include new ischaemic stroke within 90 days,change in the NIHSS score within 14 days,modified Rankin Scale score on day 90 and other vascular or death events within 90 days.The safety endpoints include mucocutaneous haemorrhage,organ haemorrhage and intracranial haemorrhage,adverse events and severe adverse events.χ^(2)test,t-test(or Mann-Whitney test),survival analysis and Cox proportional hazards models will be conducted.The findings of the study may provide an important evidence for clinical practice for these patients.Discussion The trial will be conducted under a rational design and will provide valuable evidence on the appropriate treatment for this population.Ethics and dissemination The study was reviewed and approved by the Ethics Committee of the General Hospital of Shen-Yang Military Region(no K(2016)6).Trial registration number NCT02869009;Pre-results.展开更多
The interactions and mechanisms between sulfur and heavy metals are a growing focus of biogeochemical studies in coastal wetlands.These issues underline the fate of heavy metals bound in sediments or released into the...The interactions and mechanisms between sulfur and heavy metals are a growing focus of biogeochemical studies in coastal wetlands.These issues underline the fate of heavy metals bound in sediments or released into the system through sediments.Despite the fact that numerous published studies have suggested sulfur has a significant impact on the bioavailability of heavy metals accumulated in coastal wetlands,to date,no review article has systematically summarized those studies,particularly from the perspective of the three major components of wetland ecosystems(sediments,rhizosphere,and vegetation).The present review summarizes the studies published in the past four decades and highlights the major achievements in this field.Research and studies available thus far indicate that under anaerobic conditions,most of the potentially bioavailable heavy metals in coastal wetland sediments are fixed as precipitates,such as metal sulfides.However,fluctuations in physicochemical conditions may affect sulfur cycling,and hence,directly or indirectly lead to the conversion and migration of heavy metals.In the rhizosphere,root activities and microbes together affect the speciation and transformation of sulfur which in turn mediate the migration of heavy metals.As for plant tissues,tolerance to heavy metals is enhanced by sulfur-containing compounds via promoting a series of chelation and detoxification processes.Finally,to further understand the interactions between sulfur and heavy metals in coastal wetlands,some major future research directions are proposed.展开更多
基金supported by grants from the General Project funded by Shanghai Municipal Health Bureau in China,No.20124328the General Program funded by Shanghai Municipal Science and Technology Commission in China,No.13ZR434100+1 种基金the National Natural Science Foundation of China,No.81201468Shanghai Key Laboratory of Peripheral Nerve and Microsurgery,No.08D22270600
文摘In the treatment of brachial plexus injury, nerves that are functionally less important are transferred onto the distal ends of damaged crucial nerves to help recover neuromuscular function in the target region. For example, intercostal nerves are transferred onto axillary nerves, and accessory nerves are transferred onto suprascapular nerves, the phrenic nerve is transferred onto the musculocutaneous nerves, and the contralateral C7 nerve is transferred onto the median or radial nerves. Nerve transfer has become a major method for reconstructing the brachial plexus after avulsion injury. Many experiments have shown that nerve transfers for treatment of brachial plexus injury can help reconstruct cerebral cortical function and increase cortical plasticity. In this review article, we summarize the recent progress in the use of diverse nerve transfer methods for the repair of brachial plexus injury, and we discuss the impact of nerve transfer on cerebral cortical plasticity after brachial plexus injury.
基金supported by the National Natural Science Foundation of China(21233008,21103175 and 20803074)the"Strategic Priority Research Program-Climate Change:Carbon Budget and Related Issues"of the Chinese Academy of Sciences(XDA05010203)
文摘Efficient catalytic oxidation of ethylbenzene to acetophenone was realized using the catalytic system of cobalt zeolitic imidazolate framework ZIF-67/N-hydroxyphthalimide (NHPI) under mild conditions. 95.2% conversion of ethylbenzene with 90.3% selectivity to acetophenone could be obtained at 373 K under 0.3 MPa 02 for 9 h. The results show that there exists synergetic effect between ZIF-67 and NHPI. 1-Phenylethyl hydroperoxide (PEHP) was generated via a radical process involving the hydrogen abstraction from ethylbenzene by phthalimide N-oxyl, and subsequently effectively decomposed to acetophenone by ZIF-67.
基金supported by the National Natural Science Foundation of China (No. 40971257,41171365)the Environmental Nonprofit Research and Special Project of China (No. 201009004)the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT0941)
文摘Intensive daytime and nighttime sampling was carried out from 23 Oct to 31 Dec 2008 to investigate the occurrence of nitrated polycyclic aromatic hydrocarbons (NPAHs) in PM1o at a roadside site in Xiamen, China. At the same time, six PMt0 samples were collected from a nearby roadway tunnel for comparison. Six NPAHs, namely 9-nitroanthracene, 2- and 3-nitrofluoranthene, 1- nitropyrene, 7-nitrobenz[a]anthracene, and 6-nitrobenzo[a]pyrene, were identified and quantified using GC/MS in negative ion chemical ionization mode. The average total concentration of six NPAHs (~NPAHs) in the cold season (26 Nov-31 Dec) was 2.3 (daytime) and 9.9 (nighttime) times higher than those in the warm season. Significant statistical difference (p 〈 0.01, 2-tailed) of ∑NPAHs between daytime and nighttime was found during both the warm and cold seasons. NPAHs were significantly positively correlated with their parent PAHs and nitrogen dioxide but negatively correlated with ambient temperature. The ratio of 2 + 3-nitrofluoranthene to 1- nitropyrene exhibited a similar diurnal pattern as ZNPAHs and was generally greater than 5, indicating the importance of secondary atmospheric formation. The diurnal variations of NPAHs were all influenced by the diurnal variations of PAHs, nitrogen dioxide, sunlight, and temperature. The daily inhalable exposure to the six NPAHs in the tunnel was much higher than the roadside values in the warm season but only slightly higher than those in the cold season.
基金the Natural Science Foundation of Shandong Province(ZR2017MEE021),China。
文摘Fe-based composite coatings were fabricated on 5 CrNiMo die steel by laser beam melting a precursor mixture of ferrotitanium,ferrochromium,ferromolybdenum,B4 C and Y2 O3 powders.Micro structure and properties of the coatings were studied by X-ray diffraction(XRD),scanning electron microscopy(SEM),energy-dispersive spectrometer(EDS),resistance furnace and high-temperature tribometer.The results show that(Ti,Mo)C particles with flower-like and(Ti,Mo)B2 with block-like shapes are in situ formed during laser cladding.Volume faction of multiple ceramic particles increases with the increasing of Y2 O3.The cumulative oxidation mass of the coating with 2 wt% Y2 O3 is decreased by one-third than that of the coating without Y2 O3.The oxidation layer of the coating with Y2 O3 is getting smooth.Meanwhile,high temperature wear volume loss of the coating with 2 wt% Y2 O3 is about 40% that of the coating without Y2 O3.The coating with 2 wt% Y2 O3 shows a smoother wear scar and few flat grooves are observed after high temperature wear test.
基金This study was funded by National Key R&D Program of China(2017YFC1308200)Stroke Prevention and Treatment Project of the National Health Commission-Research and Popularization of Appropriate Intervention Technology for the Stroke High Risk Group in China(GN-2016R0008).
文摘Background Intravenous recombinant tissue plasminogen activator(r-tPA)and urokinase(UK)are both recommended for the treatment of acute ischaemic stroke(AIS)in China,but with few comparative outcome data being available.We aimed to compare the outcomes of these two thrombolytic agents for the treatment of patients within 4.5 hours of onset of AIS in routine clinical practice in China.Methods A pre-planned,prospective,nationwide,multicentre,real-world registry of consecutive patients with AIS(age≥18 years)who received r-tPA or UK within 4.5 hours of symptom onset according to local decision-making and guideline recommendations during 2017-2019.The primary effectiveness outcome was the proportion of patients with an excellent functional outcome(defined by modified Rankin scale scores 0 to 1)at 90 days.The key safety endpoint was symptomatic intracranial haemorrhage according to standard definitions.Multivariable logistic regression was used for comparative analysis,with adjustment according to propensity scores to ensure balance in baseline characteristics.Results Overall,4130 patients with AIS were registered but 320 had incomplete or missing data,leaving 3810 with available data for analysis of whom 2666 received r-tPA(median dose 0.88(IQR 0.78-0.90)mg/kg)and 1144 received UK(1.71(1.43-2.00)×104 international unit per kilogram).There were several significant intergroup differences in patient characteristics:r-tPA patients were more educated,had less history of stroke,lower systolic blood pressure,greater neurological impairment and shorter treatment times from symptom onset than UK patients.However,in adjusted analysis,the frequency of excellent outcome(OR 1.18,95%CI 1.00 to 1.40,p=0.052)and symptomatic intracranial haemorrhage(OR 0.70,95%CI 0.33 to 1.47,p=0.344)were similar between groups.Conclusions UK may be as effective and carry a similar safety profile as r-tPA in treating mild to moderate AIS within guidelines in China.Registration http://www.clinicaltrials.gov.unique identifier:NCT02854592.
基金The work was supported by grants from the Science and Technology Project Plan of Liaoning Province(2014225008).
文摘Background A recent study shows that dual antiplatelet therapy with clopidogrel plus aspirin is superior to aspirin monotherapy for minor stroke,which is defined as a National Institutes of Health Stroke Scale(NIHSS)score of≤3.However,acute mild-moderate ischaemic stroke(4≤NIHSS≤10)still needs aggressive antiplatelet intervention to prevent deterioration and recurrence of stroke.The efficacy and safety of dual antiplatelet therapy versus aspirin monotherapy in the population are not clear.A multicentre clinical trial is designed to evaluate the efficacy and safety of clopidogrel plus aspirin therapy versus aspirin monotherapy within 48 hours of symptom onset of mild-moderate ischaemic stroke.Methods/Design The study is a randomised,open-label,multicentre,prospective trial with a target enrolment of 2700 patients from 60 centres in Northeast China.A treatment allocation identification number to each enrolled patient will be provided by a random number generator.The follow-up time for the clopidogrel plus aspirin and aspirin monotherapy groups is 90 days.The primary efficacy endpoint is a stroke progression event,which is defined as≥4 point increase in the NIHSS score in 48 hours.The second efficacy endpoints include new ischaemic stroke within 90 days,change in the NIHSS score within 14 days,modified Rankin Scale score on day 90 and other vascular or death events within 90 days.The safety endpoints include mucocutaneous haemorrhage,organ haemorrhage and intracranial haemorrhage,adverse events and severe adverse events.χ^(2)test,t-test(or Mann-Whitney test),survival analysis and Cox proportional hazards models will be conducted.The findings of the study may provide an important evidence for clinical practice for these patients.Discussion The trial will be conducted under a rational design and will provide valuable evidence on the appropriate treatment for this population.Ethics and dissemination The study was reviewed and approved by the Ethics Committee of the General Hospital of Shen-Yang Military Region(no K(2016)6).Trial registration number NCT02869009;Pre-results.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.32071521,31800429,and 42067012)the Natural Science Foundation of Jiangsu Province(Nos.BK20170540 and BK20210751)+2 种基金the Scientific Research Foundation for Senior Talent of Jiangsu University,China(No.20JDG067)the Science and Technology Program of Gansu Province of China(No.20JR5RA532)the MEL Visiting Fellowship of Xiamen University and Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment,China.
文摘The interactions and mechanisms between sulfur and heavy metals are a growing focus of biogeochemical studies in coastal wetlands.These issues underline the fate of heavy metals bound in sediments or released into the system through sediments.Despite the fact that numerous published studies have suggested sulfur has a significant impact on the bioavailability of heavy metals accumulated in coastal wetlands,to date,no review article has systematically summarized those studies,particularly from the perspective of the three major components of wetland ecosystems(sediments,rhizosphere,and vegetation).The present review summarizes the studies published in the past four decades and highlights the major achievements in this field.Research and studies available thus far indicate that under anaerobic conditions,most of the potentially bioavailable heavy metals in coastal wetland sediments are fixed as precipitates,such as metal sulfides.However,fluctuations in physicochemical conditions may affect sulfur cycling,and hence,directly or indirectly lead to the conversion and migration of heavy metals.In the rhizosphere,root activities and microbes together affect the speciation and transformation of sulfur which in turn mediate the migration of heavy metals.As for plant tissues,tolerance to heavy metals is enhanced by sulfur-containing compounds via promoting a series of chelation and detoxification processes.Finally,to further understand the interactions between sulfur and heavy metals in coastal wetlands,some major future research directions are proposed.