Lower lymphocyte to monocyte ratio is a potential predictor of poor outcome in patients with cerebral venous sinus thrombosis

Background Lymphocyte to monocyte ratio(LMR)is associated with functional outcome in patients with stroke.But the relationship between the LMR value and the prognosis of cerebral venous sinus thrombosis(CVST)has not been investigated.Methods CVST patients,admitted to the First Affiliated Hospital of Zhengzhou University,were retrospectively identified from November 2010 to January 2017.Functional outcomes of patients were evaluated with the modified Rankin Scale(mRS).Patients were divided into good(mRS 0-2)and poor(mRS 3-6)outcomes groups.Univariate and multivariate Cox regression analyses were used to assess the relationship between LMR and the poor survival outcome.Results A total of 228 patients were included of which 41 had poor outcomes(18.0%).The duration of follow-up was 22 months(6-66 months).LMR(2.3±1.2 vs 3.2±1.8,p<0.01)was significantly lower in the poor outcome group.Multivariate Cox regression analysis showed that LMR(HR 0.726,95%CI 0.546 to 0.964,p=0.027)was a independent predictor of poor prognosis.Conclusions LMR may be a predictor of poor prognosis in CVST patients.

Citation versus altmetrics of papers published in PLOS ONE:A comparative analysis of six countries

With the development of open access,more scientific papers show the multi-dimensional academic impact,which makes researchers focus on the comparison between altmetrics and citations.By the use of statistical analysis,we compare the citation and altmetrics of open access papers published in PLoS in past 10 years by 6 countries which are selected in terms of regional distribation,scientific level,native language,etc.,and find the following conclusions:Firstly,the level of scientific development and publication content in different countries have more effect on the 4 indicators of"citation","save","view"and"share"than the native language.Second,there is a significantly positive correlation between"citation"and"save"in the 6 countries,so as the"citation"and"view",while the altmetrics of"share"is just opposite.Therefore,to some extent,the altmetrics of"view"and"save"could be used to evaluate the scientific influence as a complement measurement of traditional citation metrics.Moreover,correlation coefficients between citations and part of altmetrics of the 6 countries are strong.Finally,the curve peaks of the 6 countries occurred in different years,papers published by developed countries have been active for slightly longer than that by developing countries.In detail,the"citation","save"and"view"peaks occurred later in developing countries such as China and Brazil than in some developed countries.Besides,the"share"peak occurred after 6 or 7 years,which is similar for the 6 countries.

Optimal Procurement Management by Reverse Auctions for a Price-Setting Newsvendor

In this paper, we study the optimal procurement management by reverse auctions for a price-setting newsvendor(retailer) in a single period setting. The retailer facing price-dependent stochastic demand first designs a procurement contract and then invites the suppliers to bid for this contract in the reverse auction. The winning supplier produces and delivers the demanded quantity.The retailer obtains the procurement quantity and simultaneously determines the retail price. By using the price elasticity of the lost-sales rate, we show that the retailer’s expected profit(excluding the procurement cost) is a concave function of the purchased quantity, which can be used to obtain the optimal procurement and retail pricing decisions for the retailer. Further, when the underlying random term of demand function is normally distributed under left-truncation(at 0), we get the analytical expressions of the purchased quantity and expected profit function for the retailer. Moreover, some numerical examples are given.