Acyl fluorides are powerful synthons for acylation with wide application in the synthesis of valued compounds,especially peptides.Herein,a practical and catalyst-free method for the synthesis of acyl fluorides from al...Acyl fluorides are powerful synthons for acylation with wide application in the synthesis of valued compounds,especially peptides.Herein,a practical and catalyst-free method for the synthesis of acyl fluorides from aldehydes via C(sp^(2))-H fluorination is reported.This method enables the conversion of both aliphatic and aromatic aldehydes into acyl fluorides in good to excellent yields by visible-light under mild conditions in the absence of transition-metal and external photosensitizer.A variety of functional groups were well tolerated for this transformation.This green method provides a practical pathway to synthesize acyl fluorides under mild conditions.展开更多
基金We thank the NSFC(No.21971093)the International Joint Research Centre for Green Catalysis and Synthesis(No.2016B01017)the 111 projects for support of our research.We also thank the Canada Research Chair(Tier I)foundation,the E.B.Eddy Endowment Fund,the Canada Foundation for Innovation,and the Natural Sciences and Engineering Research Council of Canada to Chao-Jun Li.
文摘Acyl fluorides are powerful synthons for acylation with wide application in the synthesis of valued compounds,especially peptides.Herein,a practical and catalyst-free method for the synthesis of acyl fluorides from aldehydes via C(sp^(2))-H fluorination is reported.This method enables the conversion of both aliphatic and aromatic aldehydes into acyl fluorides in good to excellent yields by visible-light under mild conditions in the absence of transition-metal and external photosensitizer.A variety of functional groups were well tolerated for this transformation.This green method provides a practical pathway to synthesize acyl fluorides under mild conditions.
