局部晚期中央型肺癌化疗联合免疫新辅助治疗后机器人辅助支气管袖状切除的安全性与可行性

背景与目的免疫新辅助为局部晚期肺癌治疗打开新局面。本研究探讨局部晚期中央型非小细胞肺癌(non-small cell lung cancer, NSCLC)患者在化疗联合免疫新辅助治疗后机器人辅助支气管袖状切除的安全性与可行性。方法回顾性分析2020年8月-2021年2月接受化疗联合免疫新辅助治疗后支气管袖状切除的13例局部晚期中央型NSCLC患者的临床资料,患者依据手术方式不同分为开胸手术(thoracotomy bronchial sleeve resection, TBSR)组和机器人辅助手术(robot-assisted bronchial sleeve resection,BSR)组,比较两组患者肿瘤学特征、术中和术后的资料。结果两组患者手术顺利,术后病理证实均实现肿瘤R0切除,BSR组患者无中转开胸。TBSR组中患者影像学部分缓解(partial remission, PR)率为71.43%,主要病理缓解(major pathological remissions, MPR)率为42.86%,完全病理缓解(complete pathological response, p CR)率为28.57%,BSR组分别为66.67%、50.00%和33.33%。两组患者平均手术时长、淋巴结清扫数目、术中平均出血量、术后平均引流时间、术后住院时间无明显差异,但是BSR组支气管吻合时间相对较短。两组患者均预后良好,顺利出院,术后90 d死亡率为0。结论局部晚期中央型NSCLC患者经过化疗联合免疫新辅助治疗后可实现缩瘤降期、增加R0切除率,支气管袖状切除安全可行。在遵循手术安全性和实现肿瘤R0切除两个原则的前提下可优先选择机器人行袖状切除。

The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions

Intratumoral microbiota has become research hotspots,and emerges as a non-negligent new component of tumor microenvironments(TME),due to its powerful infuence on tumor initiation,metas-tasis,immunosurveillance and prognosis despite in low-biomass.The accumulations of microbes,and their related components and metabolites within tumor tissues,endow TME with additional pluralistic features which are distinct from the conventional one.Therefore,it's definitely necessary to comprehen-sively delineate the sophisticated landscapes of tumor microbe microenvironment,as well as their func-tions and related underlying mechanisms.Herein,in this review,we focused on the fields of tumor microbe microenvironment,including the heterogeneity of intratumor microbiota in different types of tu-mors,the controversial roles of intratumoral microbiota,the basic features of tumor microbe microenvi-ronment(i.e.,pathogen-associated molecular patterns(PAMPs),typical microbial metabolites,autophagy,infammation,multi-faceted immunomodulation and chemoresistance),as well as the multi-disciplinary approach-based intervention of tumor microbiome for cancer therapy by applying wild-type or engineered live microbes,microbiota metabolites,antibiotics,synthetic biology and rationally de-signed biomaterials.We hope our work will provide valuable insight to deeply understand the interplay of cancer-immune-microbial,and facilitate the development of microbes-based tumor-specific treatments.

Super Na^(+)Half/Full Batteries and Ultrafast Na+Diffusion Kinetics of Cobalt-Nickel Selenide from Assembling Co_(0.5)Ni_(0.5)Se_(2)@NC Nanosheets into Cross-Stacked Architecture

Explorati on of adva need an ode materials for sodium-i on batteries(SIBs)is still a big challe nge due to the large radius of sodium.In this work,the hierarchical architectures assembled from N-doped carbon-coated Co_(0.5)Ni_(0.5)Se_(2)(Co_(0.5)Ni_(0.5)Se_(2)@NC)nanoparticles encapsulated into cross-stacked nano sheets have been successfully prepared from the cobalt-nickel bin ary-metal organic frameworks(CoNi-MOF)by two steps of the solid-state sele nizati on and carb on coating processes.Imports ntly,the resulta nt hierarchical Co0.5Nio:5Se2@NC architecture can achieve a satisfactory electrochemical performance,maintaining a high-rate capacity of 330 mA-h-g^(-1)1 at 3 A·g^(-1) and a stable cyclability of 100 cycles without obvious capacity decay at 0.2 A·g^(-1).The design of distinct superstructure can not only be applied to other electrode materials but also boost the forward development of energy storage systems.

Challenges in cell membrane-camouflaged drug delivery systems:Development strategies and future prospects

Extensive research has been performed on cell membrane camouflaged-based drug delivery systems in recent years.Herein,we provide an overview of the challenges in system preparation,functional design,continuous industrial production of these systems,and solution strategies for these challenges.Further,we analyze and discuss the frontier medical applications of cell membrane-camouflaged drug delivery systems in anti-inflammatory,anti-pathogenic microorganisms,and biological detoxification.This review takes a challenge-oriented perspective and seeks innovative strategies,provides a literature review of research into cell membrane-camouflaged drug delivery systems,and promotes the development of personalized clinical treatments.

Electrochemical and Pseudocapacitive Analysis of Rod-Like MoO_(2)@MoSe_(2)@NC Heterostructures for High-Performance Lithium Ion Batteries

A micro-scale rod-like heterostructure derived from molybdenum-based metal organic framework(Mo-MOF)has been successfully prepared via subsequent annealing treatment,which assembled from N-doped carbon encapsulated MoSe_(2) nanosheets grown on the surface of MoO_(2) microrod(named as MoO_(2)@MoSe_(2)@NC).For this novel heterostructure,the MoO_(2) nanoparticles assembled into rod core not only serve as supporting substrate for facilitating the fast kinetics of Li+cations inside the electrode but also protect the MoSe_(2) structure from restacking in the charge/discharge process.Moreover,the outer-layered MoSe2 nanosheets enable the fast lithium ion movement owing to its large interlayer spacing.Moreover,this unique rod-like core-shell structure composite could further effectively alleviate the structural strains caused by large volume expansion during charge/discharge process,thus leading to stable electrochemical performance when evaluated as anode material for lithium ion batteries.Electrochemical testing exhibits that the MoO_(2)@MoSe_(2)@NC heterostructure presents highly reversible capacity of 468 mAh g^(-1)at 0.5 A g^(-1)and superior rate capability(318 mAh g^(-1)even at 5.0 A g^(-1)),which is attributed to the synergistic effect of N-doped carbon encapsulated MoSe2 nanosheets and MoO_(2) nanoparticles.

Ternary Metal–Organic Framework Derived 2D Fe_(2)O_(3)/Co_(3)O_(4)/NiO/NC Heterostructured Nanosheets for Super Lithium Storage

Fe_(2)O_(3)/Co_(3)O_(4)/NiO/NC nanosheets have been successfully prepared via a two-step annealing process of ternary metal coordination polymer. Attributing to the synergistic effects of the multiple metal oxides and the unique 2D nanosheet structure, the improved electrical conductivity and effective electron/ion transfer enables Fe_(2)O_(3)/Co_(3)O_(4)/NiO/NC electrode to exhibit excellent electrochemical properties with outstanding rate capacity and cycling stability. This work may pave the way to construct ternary metal oxide electrode material with an excellent electrochemical performance by introducing multiple metal oxides.

Improving Na^(+)transport kinetics and Na^(+)storage of hierarchical rhenium-nickel sulfide(ReS_(2)@NiS_(2))hollow architecture by assembling layered 2D-3D heterostructures

Mixed metal sulfides have been widely used as anode material of sodium-ion batteries(SIBs)because of their excellent conductivity and sodium ion storage performance.Herein,ReS_(2)@NiS_(2)heterostructures have been triumphantly designed and prepared through anchoring ReS_(2)nanosheet arrays on the surface of NiS_(2)hollow nanosphere.Specifically,the carbon nanospheres was used as hard template to synthesize NiS_(2)hollow spheres as the substrate and then the ultrathin two-dimensional ReS_(2)nanosheet arrays were uniformly grown on the surface of NiS_(2).The internal hollow property provides sufficient space to relieve the volume expansion,and the outer two-dimensional nanosheet realizes the rapid electron transport and insertion/extraction of Na^(+).Owing to the great improvement of the transport kinetics of Na^(+),NiS_(2)@ReS_(2)heterostructure electrode can achieve a high specific capacity of 400 mAh/g at the high current density of 1 A/g and still maintain a stable cycle stability even after 220 cycles.This hard template method not only paves a new way for the design and construct binary metal sulfide heterostructure electrode materials with outstanding electrochemical performance for Na^(+)batteries but also open up the potential applications of anode materials of SIBs.

In-situ Synthesis of Coral-Like Molybdenum Phosphide(MoP) Microspheres for Lithium-Ion Battery

Molybdenum phosphide(MoP) has attracted extensive attention as promising anode candidates for lithium-ion batteries owing to its high specific capacity,low potential range and low polarization.However,severe volume changes and intrinsic low conductivity are major challenges for further application of MoP electrode materials.In this work,a coral-like MoP microsphere encapsulated by N-doped carbon(MoP@NDC) was successfully prepared through annealing the precursor derived from self-polymerization of dopamine with phosphomolybdic acid.The introduction of carbon framework not only serves as matrix to confine MoP nanocrystals from aggregations,but also improves the electrochemical conductivity and facilitates lithium ion or electron transport on the surface of MoP.Such hierarchical structure delivered high discharge capacity of 495 mAh g^(-1) after 300 cycles with 90.1 % capacity retention,which could be attributed to the synergistic effects of MoP nanoparticles and conductive carbon network.This design strategy shows MoP@NDC electrode with applicable application as anode in lithium-ion battery.