Metal-organic frameworks-derived metal phosphides for electrochemistry application

Metal-organic frameworks(MOFs)with high porosity and variable structure have attracted extensive attention in the field of electrochemistry,but their poor conductivity and stability have limited their development.Materials derived from MOFs can maintain the structural diversity and porosity characteristics of MOFs while improving their electrical conductivity and stability.Metal phosphides play an important role in electrochemistry because they possess rich active sites,unique physicochemical properties,and a porous structure.Published results show that MOF-derived metal-phosphides materials have great promise in the field of electrochemistry due to their controllable structure,high specific surface area,high stability and excellent electrical conductivity.MOF-derived metal-phosphides with significant electrochemical properties can be obtained by simply,economical and scalable synthetic methods.This work reviews the application of MOF-derived metal phosphides in electrochemistry.Specifically,the synthesis methodology and morphological characterization of MOFs derived metal-phosphides and their application in electrochemistry are described.Based on recent scientific advances,we discuss the challenges and opportunities for future research on MOF-derived metal-phosphides materials.

CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity

Long-term use of antipsychotics is a common cause of myocardial injury and even sudden cardiac deaths that often lead to drug withdrawn or discontinuation.Mechanisms underlying antipsychotics cardiotoxicity remain largely unknown.Herein we performed RNA sequencing and found that NLRP3 inflammasome-mediated pyroptosis contributed predominantly to multiple antipsychotics cardiotoxicity.Pyroptosis-based small-molecule compound screen identified cannabinoid receptor 1(CB1R)as an upstream regulator of the NLRP3 inflammasome.Mechanistically,antipsychotics competitively bond to the CB1R and led to CB1R translocation to the cytoplasm,where CB1R directly interacted with NLRP3 inflammasome via amino acid residues 177–209,rendering stabilization of the inflammasome.Knockout of Cb1r significantly alleviated antipsychotic-induced cardiomyocyte pyroptosis and cardiotoxicity.Multi-organ-based investigation revealed no additional toxicity of newer CB1R antagonists.In authentic human cases,the expression of CB1R and NLRP3 inflammasome positively correlated with antipsychotics-induced cardiotoxicity.These results suggest that CB1R is a potent regulator of the NLRP3 inflammsome-mediated pyroptosis and smallmolecule inhibitors targeting the CB1R/NLRP3 signaling represent attractive approaches to rescue cardiac side effects of antipsychotics.

Three-dimensional Co_(2)V_(2)O_(7)·nH_(2)O superstructures assembled by nanosheets for electrochemical energy storage

Hierarchical superstructures assembled by nanosheets can effectively prevent aggregation of nanosheets and improve performance in energy storage.Therefore,we proposed a facile hydrothermal method to obtain three-dimensional(3D)superstructure assembled by nanosheets.We found that the ratio of Co^(2+)/HMTA affected the morphology of the samples,and the 3D hierarchical structures of are obtained while the ratio of Co^(2+)/HMTA is 12:25.The hierarchical structures with sufficient interior space preserves the original sheet-like dimensional components and results in sufficient active sites and efficient mass diffusion.Hence,the 3D Co_(2)V_(2)O_(7)·nH_(2)O hierarchical structure exhibits good rate capability and high stability while as electrode materials.Meanwhile,when power density is 745.13 W/kg,the assembled CVO-2//AC shows an energy density of 47.7 Wh/kg.The work displays a facile method for fabrication of 3D superstructure assembled by 2D nanosheets that can be applied in energy storage.