Effective language strategies play an essential role in traditional teaching.However,the benefits of nonverbal behavior teaching strategy in the classroom have been underestimated.Facial expressions,gestures,and eye c...Effective language strategies play an essential role in traditional teaching.However,the benefits of nonverbal behavior teaching strategy in the classroom have been underestimated.Facial expressions,gestures,and eye contact are all instantaneous nonverbal behaviors that play a significant part in exchanging information in classroom.This study aims to examine how different nonverbal teaching strategies affect teaching and learning and discover what it is used for and how important they are in education.Finally,some suggestions for improving teachers’use of nonverbal behaviors from a teacher professional development perspective are presented.展开更多
The current status of nitrogen containing stainless steels at home and aboard has been introduced. The function and existing forms of nitrogen in the stainless steels, influence of nitrogen on mechanical properties an...The current status of nitrogen containing stainless steels at home and aboard has been introduced. The function and existing forms of nitrogen in the stainless steels, influence of nitrogen on mechanical properties and anti-corrosion properties as well as the application of nitrogen containing cast stainless steels were discussed in this paper. It is clear that nitrogen will be a potential and important alloying element in stainless steels. And Argon Oxygen Decarbonization (AOD) refining can provide an advanced manufacture process for nitrogen containing stainless steels with ultra-low- carbon and high cleanliness.展开更多
Microglia play a pivotal role in clearance of Aβ by degrading them in lysosomes, countering amyloid pla- que pathogenesis in Alzheimer＇s disease （AD）. Recent evidence suggests that lysosomal dysfunction leads to i...Microglia play a pivotal role in clearance of Aβ by degrading them in lysosomes, countering amyloid pla- que pathogenesis in Alzheimer＇s disease （AD）. Recent evidence suggests that lysosomal dysfunction leads to insufficient elimination of toxic protein aggregates. We tested whether enhancing lysosomal function with transcription factor EB （TFEB）, an essential regulator modulating lysosomal pathways, would promote Aβ clearance in microglia. Here we show that microglial expression of TFEB facilitates fibrillar Aβ （fAβ） degra- dation and reduces deposited amyloid plaques, which are further enhanced by deacetylation of TFEB. Using mass spectrometry analysis, we firstly confirmed acetylation as a previously unreported modification of TFEB and found that SIRT1 directly interacted with and deacetylated TFEB at lysine residue 116. Subsequently, SIRT1 overexpression enhanced lysosomal function and fAβ degradation by upregulating transcriptional levels of TFEB downstream targets, which could be inhibited when TFEB was knocked down. Furthermore, overexpression of deacetylated TFEB at K116R mutant in microglia accelerated intracellular fAβ degradation by stimulating lysosomal biogenesis and greatly reduced the deposited amyloid plaques in the brain slices of APPIPS1 transgenic mice. Our findings reveal that deacetylaUon of TFEB could regulate lysosomal biogenesis and fAβ degradation, making microglial activation of TFEB a possible strategy for attenuating amyloid plaque deposition in AD.展开更多
文摘Effective language strategies play an essential role in traditional teaching.However,the benefits of nonverbal behavior teaching strategy in the classroom have been underestimated.Facial expressions,gestures,and eye contact are all instantaneous nonverbal behaviors that play a significant part in exchanging information in classroom.This study aims to examine how different nonverbal teaching strategies affect teaching and learning and discover what it is used for and how important they are in education.Finally,some suggestions for improving teachers’use of nonverbal behaviors from a teacher professional development perspective are presented.
文摘The current status of nitrogen containing stainless steels at home and aboard has been introduced. The function and existing forms of nitrogen in the stainless steels, influence of nitrogen on mechanical properties and anti-corrosion properties as well as the application of nitrogen containing cast stainless steels were discussed in this paper. It is clear that nitrogen will be a potential and important alloying element in stainless steels. And Argon Oxygen Decarbonization (AOD) refining can provide an advanced manufacture process for nitrogen containing stainless steels with ultra-low- carbon and high cleanliness.
文摘Microglia play a pivotal role in clearance of Aβ by degrading them in lysosomes, countering amyloid pla- que pathogenesis in Alzheimer＇s disease （AD）. Recent evidence suggests that lysosomal dysfunction leads to insufficient elimination of toxic protein aggregates. We tested whether enhancing lysosomal function with transcription factor EB （TFEB）, an essential regulator modulating lysosomal pathways, would promote Aβ clearance in microglia. Here we show that microglial expression of TFEB facilitates fibrillar Aβ （fAβ） degra- dation and reduces deposited amyloid plaques, which are further enhanced by deacetylation of TFEB. Using mass spectrometry analysis, we firstly confirmed acetylation as a previously unreported modification of TFEB and found that SIRT1 directly interacted with and deacetylated TFEB at lysine residue 116. Subsequently, SIRT1 overexpression enhanced lysosomal function and fAβ degradation by upregulating transcriptional levels of TFEB downstream targets, which could be inhibited when TFEB was knocked down. Furthermore, overexpression of deacetylated TFEB at K116R mutant in microglia accelerated intracellular fAβ degradation by stimulating lysosomal biogenesis and greatly reduced the deposited amyloid plaques in the brain slices of APPIPS1 transgenic mice. Our findings reveal that deacetylaUon of TFEB could regulate lysosomal biogenesis and fAβ degradation, making microglial activation of TFEB a possible strategy for attenuating amyloid plaque deposition in AD.
