In this paper,the construction process of a cable-stayed bridge with corrugated steel webs was monitored.Moreover,the end performance of the bridge was verified by load test.Owing to the consideration of the bridge st...In this paper,the construction process of a cable-stayed bridge with corrugated steel webs was monitored.Moreover,the end performance of the bridge was verified by load test.Owing to the consideration of the bridge structure safety,it is necessary to monitor the main girder deflection,stress,construction error and safety state during construction.Furthermore,to verify whether the bridge can meet the design requirements,the static and dynamic load tests are carried out after the completion of the bridge.The results of construction monitoring show that the stress state of the structure during construction is basically consistent with the theoretical calculation and design requirements,and both meet the design and specification requirements.The final measured stress state of the structure is within the allowable range of the cable-stayed bridge,and the stress state of the structure is normal and meets the specification requirements.The results of load tests show that the measured deflection values of the mid-span section of the main girder are less than the theoretical calculation values.The maximum deflection of the girder is−20.90 mm,which is less than−22.00 mm of the theoretical value,indicating that the girder has sufficient structural stiffness.The maximum impact coefficient under dynamic load test is 1.08,which is greater than 1.05 of theoretical value,indicating that the impact effect of heavy-duty truck on this type of bridge is larger.This study can provide important reference value for construction and maintenance of similar corrugated steel web cable-stayed bridges.展开更多
A bioresponsive polymeric nanocarrier for drug delivery is able to alter its physical and physicochemical properties in response to a variety of biological signals and pathological changes,and can exert its therapeuti...A bioresponsive polymeric nanocarrier for drug delivery is able to alter its physical and physicochemical properties in response to a variety of biological signals and pathological changes,and can exert its therapeutic efficacy within a confined space.These nanosystems can optimize the biodistribution and subcellular location of therapeutics by exploiting the differences in biochemical properties between tumors and normal tissues.Moreover,bioresponsive polymer-based nanosystems could be rationally designed as precision therapeutic platforms by optimizing the combination of responsive elements and therapeutic components according to the patient-specific disease type and stage.In this review,recent advances in smart bioresponsive polymeric nanosystems for cancer chemotherapy and immunotherapy will be summarized.We mainly discuss three categories,including acidity-sensitive,redox-responsive,and enzyme-triggered polymeric nanosystems.The important issues regarding clinical translation such as reproducibility,manufacture,and probable toxicity,are also commented.展开更多
基金We would like to express our deep gratitude to the 2021 Liaoning Province Doctoral Research Start-Up Fund Project(2021-BS-168)for financial support.
文摘In this paper,the construction process of a cable-stayed bridge with corrugated steel webs was monitored.Moreover,the end performance of the bridge was verified by load test.Owing to the consideration of the bridge structure safety,it is necessary to monitor the main girder deflection,stress,construction error and safety state during construction.Furthermore,to verify whether the bridge can meet the design requirements,the static and dynamic load tests are carried out after the completion of the bridge.The results of construction monitoring show that the stress state of the structure during construction is basically consistent with the theoretical calculation and design requirements,and both meet the design and specification requirements.The final measured stress state of the structure is within the allowable range of the cable-stayed bridge,and the stress state of the structure is normal and meets the specification requirements.The results of load tests show that the measured deflection values of the mid-span section of the main girder are less than the theoretical calculation values.The maximum deflection of the girder is−20.90 mm,which is less than−22.00 mm of the theoretical value,indicating that the girder has sufficient structural stiffness.The maximum impact coefficient under dynamic load test is 1.08,which is greater than 1.05 of theoretical value,indicating that the impact effect of heavy-duty truck on this type of bridge is larger.This study can provide important reference value for construction and maintenance of similar corrugated steel web cable-stayed bridges.
基金the National Key R&D Program of China(No.2021YFA0909900)the National Natural Science Foundation of China(No.52173142)Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents,and the grants from the Startup Package of Zhejiang University.
文摘A bioresponsive polymeric nanocarrier for drug delivery is able to alter its physical and physicochemical properties in response to a variety of biological signals and pathological changes,and can exert its therapeutic efficacy within a confined space.These nanosystems can optimize the biodistribution and subcellular location of therapeutics by exploiting the differences in biochemical properties between tumors and normal tissues.Moreover,bioresponsive polymer-based nanosystems could be rationally designed as precision therapeutic platforms by optimizing the combination of responsive elements and therapeutic components according to the patient-specific disease type and stage.In this review,recent advances in smart bioresponsive polymeric nanosystems for cancer chemotherapy and immunotherapy will be summarized.We mainly discuss three categories,including acidity-sensitive,redox-responsive,and enzyme-triggered polymeric nanosystems.The important issues regarding clinical translation such as reproducibility,manufacture,and probable toxicity,are also commented.
