Dear Editor,In recent years,owing to the fact that antibiotic-resistant bacteria have become more and more prevalent,there has been a resurgence of interest in the use of bacteriophages.However,bacteriophage therapy r...Dear Editor,In recent years,owing to the fact that antibiotic-resistant bacteria have become more and more prevalent,there has been a resurgence of interest in the use of bacteriophages.However,bacteriophage therapy remains an underutilized option in modern medicine due to technical hurdles such as limited host range,narrow spectrum of展开更多
The paper introduces the method of high-density seismic imaging exploration, discusses its features different from conventional shallow seismic reflection wave technique, and illustrates the application effect of the ...The paper introduces the method of high-density seismic imaging exploration, discusses its features different from conventional shallow seismic reflection wave technique, and illustrates the application effect of the method using three samples of engineering geological explorations on land and in water exploration of underground cavity, location survey of sunk ship and investigation of channel silt depth.展开更多
The sediment reaction and diffusion equation,with generalized initial mid boundary condition is studied. By using Laplace transform and Jordan lemma, an analytical solution is got,,which is an extension of analytical ...The sediment reaction and diffusion equation,with generalized initial mid boundary condition is studied. By using Laplace transform and Jordan lemma, an analytical solution is got,,which is an extension of analytical solution provided by Cheng Kwokming James ( only diffusion was considered in analytical solution of Cheng). Some problems arisen in the computation of analytical solution formula are also analysed.展开更多
Random iterated function systems (IFSs) is discussed, which is one of the methods for fractal drawing. A certain figure can be reconstructed by a random IFS. One approach is presented to determine a new random IFS, th...Random iterated function systems (IFSs) is discussed, which is one of the methods for fractal drawing. A certain figure can be reconstructed by a random IFS. One approach is presented to determine a new random IFS, that the figure reconstructed by the new random IFS is the image of the origin figure reconstructed by old IFS under a given affine transformation. Two particular examples are used to show this approach.展开更多
The decay of weakly swirling flows in a type of cross-section-varying pipes was discussed analytically. For laminar swirling flow, the feature of exponential decay was demonstrated. For turbulent swirling flow, in spi...The decay of weakly swirling flows in a type of cross-section-varying pipes was discussed analytically. For laminar swirling flow, the feature of exponential decay was demonstrated. For turbulent swirling flow, in spite of the decay of circulation flux, a necessary condition for local circulation to amplify along downstream was obtained under the Boussinesq's hypothesis.展开更多
Summary: To compare the anti-tumor effects of transmembrane TNF-α (TM-TNF) and secreted TNF-α (S-TNF) in vivo, mouse fibroblasts NIH3T3 were transfected separately with three types of retrovirus containing wild type...Summary: To compare the anti-tumor effects of transmembrane TNF-α (TM-TNF) and secreted TNF-α (S-TNF) in vivo, mouse fibroblasts NIH3T3 were transfected separately with three types of retrovirus containing wild type TNF-α (Wt-TNF), TM-TNF mutant (TM-TNFm), S-TNF mutant (S-TNFm). Southern blot, RT-PCR, FACS and bioassay were used to investigate TNF-α gene integration, expression and its biological activity. It was found that both fixed cells and supernatant of NIH3T3/Wt-TNF, the fixed cells of NIH3T3/TM-TNFm and the supernatant of NIH3T3/S-TNFm could express high level of TNF-α or its mutants and effectively kill H22 in vitro. The transfected NIH3T3 were separately injected into the mice at the sites of H22 tumor cell inoculation according to a ratio of 5∶1 or 1∶1 (effector/target cells, E/T) after the third day of H22 challenge, respectively. At the E/T=5∶1, the NIH3T3/TM-TNFm induced the highest tumor regression, while NIH3T3/S-TNFm exerted the strongest tumor depressing effect at the E/T=1∶1 in vivo. No obvious side effects were noted throughout the course of treatment. The results suggest that both TM-TNF and S-TNF could cause tumor regression. The anti-tumor effect of TM-TNF would be more powerful and safe than that of S-TNF at the proper E/T ratio.展开更多
Concurrent Engineering (CE) is an effective way for enterprises to reengineer the product development processes and to improve the product development abilities. In this paper, the existing status of product developme...Concurrent Engineering (CE) is an effective way for enterprises to reengineer the product development processes and to improve the product development abilities. In this paper, the existing status of product development in Chinese manufacturing industry is analyzed, and the requirements of manufacturing technology for them are investigated. An overview of our CE R&D work is introduced, including product modeling, DFA, DFM, QFD, PDM, and other enabling technologies. A case study of the CE pilot project is discussed. The industrial implementation and application in Chinese enterprises are summarized.展开更多
基金supported by the Natural Science Foundation of China(30571637)
文摘Dear Editor,In recent years,owing to the fact that antibiotic-resistant bacteria have become more and more prevalent,there has been a resurgence of interest in the use of bacteriophages.However,bacteriophage therapy remains an underutilized option in modern medicine due to technical hurdles such as limited host range,narrow spectrum of
文摘The paper introduces the method of high-density seismic imaging exploration, discusses its features different from conventional shallow seismic reflection wave technique, and illustrates the application effect of the method using three samples of engineering geological explorations on land and in water exploration of underground cavity, location survey of sunk ship and investigation of channel silt depth.
文摘The sediment reaction and diffusion equation,with generalized initial mid boundary condition is studied. By using Laplace transform and Jordan lemma, an analytical solution is got,,which is an extension of analytical solution provided by Cheng Kwokming James ( only diffusion was considered in analytical solution of Cheng). Some problems arisen in the computation of analytical solution formula are also analysed.
文摘Random iterated function systems (IFSs) is discussed, which is one of the methods for fractal drawing. A certain figure can be reconstructed by a random IFS. One approach is presented to determine a new random IFS, that the figure reconstructed by the new random IFS is the image of the origin figure reconstructed by old IFS under a given affine transformation. Two particular examples are used to show this approach.
文摘The decay of weakly swirling flows in a type of cross-section-varying pipes was discussed analytically. For laminar swirling flow, the feature of exponential decay was demonstrated. For turbulent swirling flow, in spite of the decay of circulation flux, a necessary condition for local circulation to amplify along downstream was obtained under the Boussinesq's hypothesis.
文摘Summary: To compare the anti-tumor effects of transmembrane TNF-α (TM-TNF) and secreted TNF-α (S-TNF) in vivo, mouse fibroblasts NIH3T3 were transfected separately with three types of retrovirus containing wild type TNF-α (Wt-TNF), TM-TNF mutant (TM-TNFm), S-TNF mutant (S-TNFm). Southern blot, RT-PCR, FACS and bioassay were used to investigate TNF-α gene integration, expression and its biological activity. It was found that both fixed cells and supernatant of NIH3T3/Wt-TNF, the fixed cells of NIH3T3/TM-TNFm and the supernatant of NIH3T3/S-TNFm could express high level of TNF-α or its mutants and effectively kill H22 in vitro. The transfected NIH3T3 were separately injected into the mice at the sites of H22 tumor cell inoculation according to a ratio of 5∶1 or 1∶1 (effector/target cells, E/T) after the third day of H22 challenge, respectively. At the E/T=5∶1, the NIH3T3/TM-TNFm induced the highest tumor regression, while NIH3T3/S-TNFm exerted the strongest tumor depressing effect at the E/T=1∶1 in vivo. No obvious side effects were noted throughout the course of treatment. The results suggest that both TM-TNF and S-TNF could cause tumor regression. The anti-tumor effect of TM-TNF would be more powerful and safe than that of S-TNF at the proper E/T ratio.
文摘Concurrent Engineering (CE) is an effective way for enterprises to reengineer the product development processes and to improve the product development abilities. In this paper, the existing status of product development in Chinese manufacturing industry is analyzed, and the requirements of manufacturing technology for them are investigated. An overview of our CE R&D work is introduced, including product modeling, DFA, DFM, QFD, PDM, and other enabling technologies. A case study of the CE pilot project is discussed. The industrial implementation and application in Chinese enterprises are summarized.
