Clinical effects of nonconvulsive electrotherapy combined with mindfulness-based stress reduction and changes of serum inflammatory factors in depression

BACKGROUND Depression is a common and serious psychological condition,which seriously affects individual well-being and functional ability.Traditional treatment methods include drug therapy and psychological counseling;however,these methods have different degrees of side effects and limitations.In recent years,nonconvulsive electrotherapy(NET)has attracted increasing attention as a noninvasive treatment method.However,the clinical efficacy and potential mechanism of NET on depression are still unclear.We hypothesized that NET has a positive clinical effect in the treatment of depression,and may have a regulatory effect on serum inflammatory factors during treatment.AIM To assess the effects of NET on depression and analyze changes in serum inflammatory factors.METHODS This retrospective study enrolled 140 patients undergoing treatment for depression between May 2017 and June 2022,the observation group that received a combination of mindfulness-based stress reduction(MBSR)and NET treatment(n=70)and the control group that only received MBSR therapy(n=70).The clinical effectiveness of the treatment was evaluated by assessing various factors,including the Hamilton Depression Scale(HAMD)-17,self-rating idea of suicide scale(SSIOS),Pittsburgh Sleep Quality Index(PSQI),and levels of serum inflammatory factors before and after 8 wk of treatment.The quality of life scores between the two groups were compared.Comparisons were made using t and χ^(2) tests.RESULTS After 8 wk of treatment,the observation group exhibited a 91.43%overall effectiveness rate which was higher than that of the control group which was 74.29%(64 vs 52,χ^(2)=7.241;P<0.05).The HAMD,SSIOS,and PSQI scores showed a significant decrease in both groups.Moreover,the observation group had lower scores than the control group(10.37±2.04 vs 14.02±2.16,t=10.280;1.67±0.28 vs 0.87±0.12,t=21.970;5.29±1.33 vs 7.94±1.35,t=11.700;P both<0.001).Additionally,there was a notable decrease in the IL-2,IL-1β,and IL-6 in both groups after treatment.Furthermore,the observation group exhibited superior serum inflammatory factors compared to the control group(70.12±10.32 vs 102.24±20.21,t=11.840;19.35±2.46 vs 22.27±2.13,t=7.508;32.25±4.6 vs 39.42±4.23,t=9.565;P both<0.001).Moreover,the observation group exhibited significantly improved quality of life scores compared to the control group(Social function:19.25±2.76 vs 16.23±2.34;Emotions:18.54±2.83 vs 12.28±2.16;Environment:18.49±2.48 vs 16.56±3.44;Physical health:19.53±2.39 vs 16.62±3.46;P both<0.001)after treatment.CONCLUSION MBSR combined with NET effectively alleviates depression,lowers inflammation(IL-2,IL-1β,and IL-6),reduces suicidal thoughts,enhances sleep,and improves the quality of life of individuals with depression.

源荷储协调的冷热电综合能源系统随机优化运行

冷热电综合能源系统是促进多种能源综合利用的重要载体,也是能源互联网发展的重要基础。为实现源荷双重不确定时冷热电综合能源系统的运行优化,并充分发挥源荷储各环节的调控潜力,本文提出了一种考虑源荷储协调的冷热电综合能源系统随机优化运行方法。首先采用非参数核密度估计与概率场景抽样相结合的方法对综合能源系统中源荷不确定性进行挖掘和表征,在此基础上,全面考虑储电、储冷、储热等多种能源存储形式及负荷需求响应措施,建立了源荷储协调的冷热电综合能源系统随机优化运行模型。针对模型中能源存储设备的运行时段耦合约束和日运行能量平衡约束等带来的复杂多阶段决策问题,提出基于序列二次规划算法的模型求解方法。以某典型冷热电综合能源系统为测试算例,对不考虑储能、不考虑需求响应及详细考虑源荷储协调的多种情形进行了对比分析,结果证明了所提模型和方法的有效性。

经脐取标本并脐整形术在腹腔镜乙状结肠癌根治术中应用的对比研究

目的探讨腹腔镜乙状结肠癌根治经脐取标本并脐整形术的临床优势及应用前景。方法按完全随机化原则将遵义医学院附属成都市第二人民医院普外科2015年1月-2016年12月收治的60例乙状结肠癌患者分为试验组和对照组(该研究采用随机数字表法进行分组)。试验组30例患者行腹腔镜乙状结肠癌根治经脐取标本并脐整形术,对照组30例患者同期行传统腹腔镜乙状结肠癌根治术。比较两组手术的安全性、近期临床疗效、肿瘤根治性、术后相关并发症及美容效果等。结果两组患者的性别、年龄、体质指数(BMI)、Dukes分期、原发肿瘤部位及术前病理分类等比较差异无统计学意义(P>0.05),具有可比性。两组手术时间、术中失血量、术后肠功能恢复时间、开始进食时间、术后首次下床活动时间、住院时间和住院费用等比较差异无统计学意义(P>0.05)。试验组术后镇痛剂的使用率为30.00%,对照组为56.67%,两组间比较差异具有统计学意义(P <0.05)。两组肿瘤大小、标本长度、远切缘距离和淋巴结清扫数目等比较差异无统计学意义(P>0.05)。两组术后相关并发症比较差异无统计学意义(P>0.05)。试验组的切口长度明显短于对照组,两组间比较差异有统计学意义(P <0.05)。试验组的术后视觉模拟评分(VAS)明显低于对照组,两组间比较差异有统计学意义(P <0.05)。试验组患者对切口的满意率为90.00%,对照组为63.33%,两组间比较差异具有统计学意义(P <0.05)。试验组术后腹壁疤痕隐蔽难以察觉,且肚脐形态稳定持久,近、远期美容效果满意。结论腹腔镜乙状结肠癌根治经脐取标本并脐整形术安全、可行,操作不复杂,创伤小,疼痛轻,腹壁美容效果显著,患者满意度高,值得临床推广。

An improved draft genome sequence of hybrid Populus alba×Populus glandulosa

Populus alba × P.glandulosa clone 84 K,derived from South Korea,is widely cultivated in China and used as a model in the molecular research of woody plants because of hi gh gene transformation efficiency.Here,we combined63-fold coverage Illumina short reads and 126-fold coverage PacBio long reads to assemble the genome.Due to the hi gh heterozygosity level at 2.1% estimated by k-mer analysis,we exploited TrioCanu for genome assembly.The PacBio clean subreads of P.alba × P.glandulosa were separated into two parts according to the similarities,compared with the parental genomes of P.alba and P.glandulosa.The two parts of the subreads were assembled to two sets of subgenomes comprising subgenome A(405.31 Mb,from P.alba)and subgenome G(376.05 Mb,from P.glandulosa) with the contig N50 size of 5.43 Mb and 2.15 Mb,respectively.A high-quality P.alba × P.glandulosa genome assembly was obtained.The genome size was 781.36 Mb with the contig N50 size of 3.66 Mb and the longest contig was 19.47 Mb.In addition,a total of 176.95 Mb(43.7%),152.37 Mb(40.5%)of repetitive elements were identified and a total of 38,701 and 38,449 protein-coding genes were predicted in subgenomes A and G,respectively.For functional annotation,96.98% of subgenome A and 96.96% of subgenome G genes were annotated with public databases.This de novo assembled genome will facilitate systematic and comprehensive study,such as multi-omics analysis,in the model tree P.alba X P.glandulosa.

Moirésuperlattice modulations in single-unit-cell FeTe films grown on NbSe_(2)single crystals

Interface can be a fertile ground for exotic quantum states,including topological superconductivity,Majorana mode,fractal quantum Hall effect,unconventional superconductivity,Mott insulator,etc.Here we grow single-unit-cell(1UC)FeTe film on NbSe_(2)single crystal by molecular beam epitaxy(MBE)and investigate the film in-situ with a home-made cryogenic scanning tunneling microscopy(STM)and non-contact atomic force microscopy(AFM)combined system.We find different stripe-like superlattice modulations on grown FeTe film with different misorientation angles with respect to NbSe_(2)substrate.We show that these stripe-like superlattice modulations can be understood as moirépattern forming between FeTe film and NbSe_(2)substrate.Our results indicate that the interface between Fe Te and NbSe2 is atomically sharp.By STM-AFM combined measurement,we suggest that the moirésuperlattice modulations have an electronic origin when the misorientation angle is relatively small(≤3°)and have structural relaxation when the misorientation angle is relatively large(≥10°).

Experimental Observations Indicating the Topological Nature of the Edge States on HfTe5

The topological edge states of two-dimensional topological insulators with large energy gaps furnish ideal conduction channels for dissipationless current transport. Transition metal tellurides XTe5X=Zr, Hf) are theoretically predicted to be large-gap two-dimensional topological insulators, and the experimental observations of their bulk insulating gap and in-gap edge states have been reported, but the topological nature of these edge states still remains to be further elucidated. Here, we report our low-temperature scanning tunneling microscopy/spectroscopy study on single crystals of HfTe5. We demonstrate a full energy gap of ~80 meV near the Fermi level on the surface monolayer of HfTe5 and that such an insulating energy gap gets filled with finite energy states when measured at the monolayer step edges. Remarkably, such states are absent at the edges of a narrow monolayer strip of one-unit-cell in width but persist at both step edges of a unit-cell wide monolayer groove. These experimental observations strongly indicate that the edge states of HfTe5 monolayers are not trivially caused by translational symmetry breaking, instead they are topological in nature protected by the 2 D nontrivial bulk properties.

Effects of prostacyclin derivatives combined with valsartan therapy on the blood biochemical indexes in patients with early hypertensive nephropathy

Objective:To explore the effects of prostacyclin derivatives combined with valsartan therapy on the blood biochemical indexes in patients with early hypertensive nephropathy.Methods: A total of 110 patients with hypertensive nephropathy who were treated in the hospital between December 2014 and March 2017 were divided into control group (n=55) and experimental group (n=55) by random number table method. Control group received valsartan therapy, and experimental group received prostacyclin derivatives combined with valsartan therapy, which lasted for 20 weeks. The differences in the contents of renal function indexes, urinary protein indexes and endothelial injury markers were compared between the two groups before and after treatment.Results: Before treatment, the differences in the contents of renal function indexes, urinary protein indexes and endothelial injury markers were not statistically significant between the two groups. After 20 weeks of treatment, renal function indexes SCr, BUN, UA and CysC levels in peripheral blood of experimental group were lower than those of control group;urinary protein indexes ALB,β2-MG andα1-MG contents were lower than those of control group;endothelial injury markers ET-1 and E-selectin contents in peripheral blood were lower than those of control group whereas NO and CGRP contents were higher than those of control group.Conclusion: Prostacyclin derivatives combined with valsartan therapy can effectively optimize the renal function, reduce the urinary protein and alleviate the vascular endothelial injury in patients with early hypertensive nephropathy and improve the overall therapeutic effect.

MicroRNA319-mediated gene regulatory network impacts leaf development and morphogenesis in poplar

MicroRNA319(miR319)has been implicated in leaf development in a number of plant species.Here we study the roles of miR319a and its regulated network in leaf development in poplars.Over-expression of miR319a in Populus alba×Populus glandulosa caused dwarf statures,narrow leaf blades and serrated leaf margins.The vascular bundles and bundle sheaths in transgenic leaves had more layers of cells than those in the leaves of control plants,indicating enhanced lignification in these cells.Among the 93 putative targets of miR319a predicted with the psRNATarget tool,only three genes,TCP(TEOSINTE BRANCHED1,CYCLOIDEA,and PROLIFERATING CELL NUCLEAR ANTIGEN BINDING FACTOR),were differentially expressed in the leaves of MIR319a-over-expression transgenic lines.With the RNA-seq data sets from multiple MIR319a over-expression transgenic lines,we built a three-layered gene regulatory network mediated by miR319a using Top-down graphic Gaussian model(GGM)algorithm that is capable of capturing causal relationships from transcriptomic data.The results support that miR319a primarily regulates the lignin biosynthesis,leaf development and differentiation as well as photosynthesis via miR319-MEE35/TCP4,miR319-TCP2 and miR319-TCP2-1 regulatory modules.

Single-cell RNA sequencing reveals a high-resolution cell atlas of xylem in Populus

High-throughputsingle-cellRNAsequencing(sc RNA-seq) has advantages over traditional RNA-seq to explore spatiotemporal information on gene dynamic expressions in heterogenous tissues. We performed Drop-seq, a method for the dropwise sequestration of single cells for sequencing, on protoplasts from the differentiating xylem of Populus alba × Populus glandulosa. The sc RNA-seq profiled9,798 cells, which were grouped into 12 clusters.Through characterization of differentially expressed genes in each cluster and RNA in situ hybridizations,we identified vessel cells, fiber cells, ray parenchyma cells and xylem precursor cells. Diffusion pseudotime analyses revealed the differentiating trajectory of vessels, fiber cells and ray parenchyma cells and indicated a different differentiation process between vessels and fiber cells, and a similar differentiation process between fiber cells and ray parenchyma cells. We identified marker genes for each cell type(cluster) and key candidate regulators during developmental stages of xylem cell differentiation. Our study generates a high-resolution expression atlas of wood formation at the single cell level and provides valuable information on wood formation.

老少边穷地区公共文化服务软治理路径建构研究

在国家治理现代化的大背景下,国家治理模式从“硬治理”向“软治理”变迁,公共文化具有的价值塑造、意识养成等“软”特性不断被纳入到国家治理体系之中。面对老少边穷地区公共文化服务软治理根基较弱、治理方式“水土不服”及内容供给缺位等现实困境,应从内容、主体、渠道等方面建构治理路径,内容上根植本土,服务上匹配供需,政府、群众多主体协同,不断完善市场机制,加强基础设施建设及媒介技术融合。

媒体融合语境下传媒领导力研究

在媒体融合发展的社会情境下,当代中国在职传媒从业者面临职业晋升困扰、能力"转型"和工作角色"转换"等现实挑战,个体面对的工作情景以及利益冲突日益复杂,需要他们在"实践理性"中平衡和处理自身的及与他者的各种利益,以达成在职业晋升和媒体融合大潮流中的"实践自觉"。结合职业晋升和传媒领导力的条件关系,从个体的实践中分析和提取实践理性的外在表征,阐释媒体融合环境下传媒领导力的主要特征表现和核心要素,发现传媒领导力的特征可以概念化总结为:担当、感知、学习和想象。因此,传媒从业人才应基于新时代传媒领导力的要求进行核心素养的"守正"与"创新"。

The early percutaneous coronary intervention in elderly patients with acute coronary syndrome

It is challenging to undo early percutaneous intervention(PCI)in the elderly with acute coronary syndrome(ACS).Fifteen patients older than 65 years with ACS within 24 hours of the event were admitted from April 4,2004 to December 12,2005.All the patients had early percutaneous coronary intervention and were followed up for 6-12 months by telephone or in the out-patient department.Nine of the 15 patients exhibited acute myocardial infarction(AMI).Six exhib-ited unstable angina(UA).All the patients had early PCI.The average door-to-balloon time was 78 minutes(40-110 minutes).The average PCI time was 99 minutes(68-120 minutes).Nineteen of 36 lesions in the fifteen angioplasty patients were treated and 20 stents were implanted in total.All the procedures were considered successful.Neither deaths nor recurrent angina occurred in the 6-12 months of follow-up.It was shown that early PCI might be an effective and safe method to treat eld-erly patients with ACS.