Immunotherapy targeting immune checkpoint molecules has emerged as a key approach in cancer treatment,representing the forefront of antitumor research.However,studies on immune checkpoint molecules have mainly focused...Immunotherapy targeting immune checkpoint molecules has emerged as a key approach in cancer treatment,representing the forefront of antitumor research.However,studies on immune checkpoint molecules have mainly focused on targeted therapies.Chinese medicine(CM)research as a complementary medicine has revealed that immune checkpoint molecules also undergo disease-specific changes in the context of autoimmune diseases.This review article presents a comprehensive analysis of CM studies on immune checkpoint molecules in the last 5 years,with a focus on their role in different diseases and treatment modalities.CM research predominantly utilizes oral administration of herbal plant extracts or acupuncture techniques,which stimulate the immune system by activating specific acupoints through temperature and needling.In this study,we analyzed the modulation and mechanisms of immune checkpoint molecules associated with different coinhibitory and costimulatory molecules,and reviewed the immune functions of related molecules and CM studies in treating autoimmune diseases and tumors.By summarizing the characteristics and research value of CM in regulating immune checkpoint molecules,this review aims to provide a useful reference for future studies in this field.展开更多
Objective:To observe the effects of acupoints,cone numbers and durations of moxibustion with different moxibustion methods on skin surface and inside temperature,and to provide references for the clinical standardizat...Objective:To observe the effects of acupoints,cone numbers and durations of moxibustion with different moxibustion methods on skin surface and inside temperature,and to provide references for the clinical standardization of moxibustion amount.Methods:The 42 big-ear white rabbits were divided into 6 groups according to the random number table method,a 2-cone direct moxibustion group,a 2-cone direct moxibustion group,a 3-cone direct moxibustion group,a 1-cone herbal cake-partitioned moxibustion group,a 2-cone herbal cake-partitioned moxibustion group,and a 3-cone herbal cake-partitioned moxibustion group,with 7 rabbits in each group.Shenque(CV 8);Shenshu(BL 23)and Zusanli(ST 36)were used in each group,but the moxibustion methods,cone numbers and durations of moxibustion were different・Rabbits in each group received moxibustion once every other day for 5 times in total.During the intervention,a thermoelectricity coupled probe and a temperature recorder were used to record the real-time-acupoint skin temperature and the temperature at different time points,so as to observe,analyze and process the real-time changes in the temperature difference between the surface and inside of acu point skin.Results:For herbal cake-partitioned moxibustion,the best temperature for cone changing was(46.38±0.51)℃when the highest surface temperature was(49.20±0.52)℃;the multi-factor comparison of acupoint×cone number×time and acupoint×moxibustion method×time showed that time×acupoint,time×moxibustion method and cone number×acupoint had interactive effects(all P<0.05).Comparing skin temperature differences between different cone numbers at the same acupoint,Shenque(CV 8)on the 1st and the 5th days,Shenshu(BL 23)on the 3rd and the 7th days,Zusanli(ST 36)on the 1st and the 9th days of experiment showed statistically significant differences(all P<0.05).The skin temperature comparison of different moxibustion methods at the same acupoint all had statistical differences(all Pv0.05),except for Shenque(CV 8)before moxibustion,Shenshu(BL 23)before moxibustion and on the 5th day;Zusanli(ST 36)only showed statistical differences on the 5th and 7th days(both P<0.05).The skin temperature differences of different acupoints after moxibustion in the 1-cone,2-cone and 3-cone groups were statistically different(all P<0.05);direct moxibustion and herbal cake-partitioned moxibustion at different acupoints were all statistically different(all P<0.05).Conclusion:Cone changing temperature under the same specifications of herbal cake-partitioned moxibustion was confirmed.Temperature differenee between surface and inside of different acupoint skin at the same maximum temperature was significantly different due to the cone numbers and moxibustion methods,which showed the highest at Shenshu(BL 23),the sec ond at Shenque(CV 8),and the lowest at Zusanli(ST 36).The in fluence of acupoint factor should be considered to determine the quantitative indicators of moxibustion.展开更多
基金Supported by the National Natural Science Foundation of China(Nos.82174504,81674062)the Innovation Fund of Postgraduate,Hunan University of Chinese Medicine(No.2022CX20)。
文摘Immunotherapy targeting immune checkpoint molecules has emerged as a key approach in cancer treatment,representing the forefront of antitumor research.However,studies on immune checkpoint molecules have mainly focused on targeted therapies.Chinese medicine(CM)research as a complementary medicine has revealed that immune checkpoint molecules also undergo disease-specific changes in the context of autoimmune diseases.This review article presents a comprehensive analysis of CM studies on immune checkpoint molecules in the last 5 years,with a focus on their role in different diseases and treatment modalities.CM research predominantly utilizes oral administration of herbal plant extracts or acupuncture techniques,which stimulate the immune system by activating specific acupoints through temperature and needling.In this study,we analyzed the modulation and mechanisms of immune checkpoint molecules associated with different coinhibitory and costimulatory molecules,and reviewed the immune functions of related molecules and CM studies in treating autoimmune diseases and tumors.By summarizing the characteristics and research value of CM in regulating immune checkpoint molecules,this review aims to provide a useful reference for future studies in this field.
文摘Objective:To observe the effects of acupoints,cone numbers and durations of moxibustion with different moxibustion methods on skin surface and inside temperature,and to provide references for the clinical standardization of moxibustion amount.Methods:The 42 big-ear white rabbits were divided into 6 groups according to the random number table method,a 2-cone direct moxibustion group,a 2-cone direct moxibustion group,a 3-cone direct moxibustion group,a 1-cone herbal cake-partitioned moxibustion group,a 2-cone herbal cake-partitioned moxibustion group,and a 3-cone herbal cake-partitioned moxibustion group,with 7 rabbits in each group.Shenque(CV 8);Shenshu(BL 23)and Zusanli(ST 36)were used in each group,but the moxibustion methods,cone numbers and durations of moxibustion were different・Rabbits in each group received moxibustion once every other day for 5 times in total.During the intervention,a thermoelectricity coupled probe and a temperature recorder were used to record the real-time-acupoint skin temperature and the temperature at different time points,so as to observe,analyze and process the real-time changes in the temperature difference between the surface and inside of acu point skin.Results:For herbal cake-partitioned moxibustion,the best temperature for cone changing was(46.38±0.51)℃when the highest surface temperature was(49.20±0.52)℃;the multi-factor comparison of acupoint×cone number×time and acupoint×moxibustion method×time showed that time×acupoint,time×moxibustion method and cone number×acupoint had interactive effects(all P<0.05).Comparing skin temperature differences between different cone numbers at the same acupoint,Shenque(CV 8)on the 1st and the 5th days,Shenshu(BL 23)on the 3rd and the 7th days,Zusanli(ST 36)on the 1st and the 9th days of experiment showed statistically significant differences(all P<0.05).The skin temperature comparison of different moxibustion methods at the same acupoint all had statistical differences(all Pv0.05),except for Shenque(CV 8)before moxibustion,Shenshu(BL 23)before moxibustion and on the 5th day;Zusanli(ST 36)only showed statistical differences on the 5th and 7th days(both P<0.05).The skin temperature differences of different acupoints after moxibustion in the 1-cone,2-cone and 3-cone groups were statistically different(all P<0.05);direct moxibustion and herbal cake-partitioned moxibustion at different acupoints were all statistically different(all P<0.05).Conclusion:Cone changing temperature under the same specifications of herbal cake-partitioned moxibustion was confirmed.Temperature differenee between surface and inside of different acupoint skin at the same maximum temperature was significantly different due to the cone numbers and moxibustion methods,which showed the highest at Shenshu(BL 23),the sec ond at Shenque(CV 8),and the lowest at Zusanli(ST 36).The in fluence of acupoint factor should be considered to determine the quantitative indicators of moxibustion.
