<strong>Objective:</strong> Based on the GEO database, the differential genes of sinusoidal endothelial cells in cirrhotic rats were analyzed. <strong>Methods:</strong> In the GEO database, the...<strong>Objective:</strong> Based on the GEO database, the differential genes of sinusoidal endothelial cells in cirrhotic rats were analyzed. <strong>Methods:</strong> In the GEO database, the differential gene expressions of liver sinusoidal endothelial cells in cirrhotic rats were obtained. The screening was performed according to P < 0.01 and differential multiple factor ≥ 4. The obtained genes were input into the DAVID database for enrichment analysis of genes and pathways. The GeneMania and string databases were then used for protein interaction analysis. <strong>Results:</strong> The GSE1843 dataset was obtained in the GEO database, and three pathways significantly associated with cirrhosis and 13 differential genes enriched in three pathways were screened. Text mining revealed that 11 differential genes were directly associated with cirrhosis. The other two were indirectly linked by other genes. The screened genes and known gene formation networks were discovered by the GeneMania tool. <strong>Conclusion:</strong> CDH2 and COL1A1 may be important target genes for cirrhosis.展开更多
It has been challenging to design seedling pick-up mechanism based on given key points and trajectories,because it involves dimensional synthesis and rod length optimization.In this paper,the dimensional synthesis of ...It has been challenging to design seedling pick-up mechanism based on given key points and trajectories,because it involves dimensional synthesis and rod length optimization.In this paper,the dimensional synthesis of seedling pickup mechanism with planetary gear train was studied based on the data of given key points and the trajectory of the endpoint of seedling pick-up mechanism.Given the positions and orientations requirements of the five key points,the study first conducted a dimensional synthesis of the linkage size and center of rotation.The next steps were to select a reasonable solution and optimize the data values based on the ideal seedling trajectory.The link motion was driven by the planetary gear train of the two-stage gear.Four pitch curves of noncircular gears were obtained by calculating and distributing the transmission ratio according to the data.For the pitch curve with two convex points,the tooth profile design method of incomplete noncircular gear was applied.The seedling pick-up mechanism was tested by a virtual prototype and a physical prototype designed with the obtained parameter values.The results were consistent with the theoretical design requirements,confirming that the mechanism meets the expected requirements for picking seedlings up.This paper presents a new design method of vegetable pot seedling pick-up mechanism for an automatic vegetable transplanter.展开更多
The current automatic scallion-transplanting machine is a complicated mechanism composed of two linkage mechanisms and two band carriers.It delivers seedlings ine ciently because of the movement limitations of the lin...The current automatic scallion-transplanting machine is a complicated mechanism composed of two linkage mechanisms and two band carriers.It delivers seedlings ine ciently because of the movement limitations of the linkage mechanism.This paper proposes a new high-order non-circular gear train for an automatic scallion-seedling feeding mechanism.The proposed gear train has an asymmetrical transmission ratio;i.e.,its transmission ratio varies.This allows the mechanism’s execution component to move in a long displacement and rotate in a large rotation angle.The long displacement enables the execution component to reach the designed working position,and the large rotation angle allows it to feed a scallion in the required pose.A mathematical model for calculating the asymmetrical transmission ratio was established according to the closure requirements and the full-cycle motion of the driven gear pitch curve.Then,the parameter-design model of the new seedling-feeding mechanism was established,based on precise pose points and trajectory-shape control points.Moreover,an aided-design program was developed to obtain the parameter-solution domain of the scallion-seedling feeding mechanism.The mechanism parameters,which met the seedling-feeding function,were optimized to determine the transmission ratio,using a program and a kinematic simulation.Finally,a prototype of the mechanism was produced,and a seedling-feeding experiment was carried out.One-thousand seedlings were tested at a rate of 100 seedlings per minute,and the statistical success rate was 93.4%.Thus,the automatic scallion-seedling feeding mechanism significantly improves the e ciency of automatically transplanting scallions.展开更多
Ultra-high-purity silicon tetrachloride(SiCl4)is demanded as an electronic-grade chemical to meet the stringent requirements of the rapidly developing semiconductor industry.The high requirement for ultra-high-purity ...Ultra-high-purity silicon tetrachloride(SiCl4)is demanded as an electronic-grade chemical to meet the stringent requirements of the rapidly developing semiconductor industry.The high requirement for ultra-high-purity SiCl4 has created the need for a high-efficient process for reducing energy consumption as well as satisfying product quality.In this paper,a mass of production technology of ultra-high-purity SiCl4 was successfully developed through chlorination reaction in the ultraviolet(UV)-based photo microreactor coupled with the distillation process.The influences of key operational parameters,including temperature,pressure,UV wavelength and light intensity on the product quality,especially for hydrogen-containing impurities,were quantified by the infrared transmittance of Fourier transform infrared spectroscopy(FT-IR)at 2185 cm^-1and 2160 cm^-1indicating that chara cteristic vib rational modes of Si-H bonds,as well as the operating conditions of distillation were also investigated as key factors for metal impurities removing.The advanced intensification of SiCl4 manufactured by the integration of photo microreactor and distillation achieves the products with superior specifications higher than the standard commercial products.展开更多
The elements of Green function matrix are the nonlinear functions of fault parameters estimation, the randomness of fault parameters estimation causes that the slip distribution inversion turns to be the parameter est...The elements of Green function matrix are the nonlinear functions of fault parameters estimation, the randomness of fault parameters estimation causes that the slip distribution inversion turns to be the parameter estimation problem of total least squares. Second-order approaching function method, scaled unscented transformation(SUT) method and adaptive Monte Carlo method are designed for biases of displacements in rectangular dislocation model. They are used to analyze effects of the length, width,depth and dip of fault with different variances on the corresponding displacements of unit strike slip dislocation fault, unit dip slip dislocation fault and unit tensile dislocation fault. Results of the simulated fault show that compared with second-order approaching function method and adaptive Monte Carlo method, SUT method has better computational efficiency. The second-order term has dominant effects on nonlinear relationship between displacements and the fault parameter in the rectangular dislocation model. The main biases of displacements are near to fault. The corresponding displacements of unit tensile dislocation are mostly susceptible to fault parameters estimation, followed by the unit dip slip dislocation and unit strike slip dislocation. In addition, the vertical displacement is more sensitive to fault parameters estimation than horizontal displacements.展开更多
For the determination of the smoothing factor (also known as the regularization parameter) in the co-seismic slip distribution inversion, the compromise curve between the model roughness and the data fitting residual ...For the determination of the smoothing factor (also known as the regularization parameter) in the co-seismic slip distribution inversion, the compromise curve between the model roughness and the data fitting residual is generally used to determine (in order to distinguish the method proposed in this paper, the method is called “L curve” according to its shape). Based on the L-curve, the Eclectic Intersection curve as a new method is proposed to determine the smoothing factor in this paper. The results of the simulated experiment show that the inversion accuracy of the parameters of the seismic slip distribution with the smoothing factor determined by the Eclectic Intersection curve method is better than that of the L curve method. Moreover, the Eclectic Intersection curve method and the L curve method are used to determine the smoothing factor of L’Aquila earthquake and the Taiwan Meinong earthquake slip distribution inversion respectively, and the inversion results are compared and analyzed. The analysis results show that the L’Aquila and the Taiwan Meinong actual earthquake slip distribution results are in the range of other scholars at home and abroad, and compared with the L curve method, the Eclectic Intersection curve method has advantages of high computation efficiency, no need to depend on data fitting degree and more appropriate of smoothing factor and so on.展开更多
传统的单快拍测向算法只适用于具有Vandermonde形式的阵列流型,均匀圆阵的阵列流型不具有Vandermonde矩阵结构,因此大部分基于线阵的伪协方差矩阵的构造方法无法直接适用于均匀圆阵。针对该问题,从侦察方的角度对波达方向(direction of ...传统的单快拍测向算法只适用于具有Vandermonde形式的阵列流型,均匀圆阵的阵列流型不具有Vandermonde矩阵结构,因此大部分基于线阵的伪协方差矩阵的构造方法无法直接适用于均匀圆阵。针对该问题,从侦察方的角度对波达方向(direction of arrival,DOA)估计算法进行了研究,改进了伪协方差矩阵的构造方法,提出了一种基于均匀圆阵的单快拍测向算法。通过与模式空间前后向平滑(mode forward-backward spatial smoothing,MODE-FBSS)算法的对比仿真,验证了算法的有效性,证实了所提方法的性能优于MODE-FBSS算法。展开更多
文摘<strong>Objective:</strong> Based on the GEO database, the differential genes of sinusoidal endothelial cells in cirrhotic rats were analyzed. <strong>Methods:</strong> In the GEO database, the differential gene expressions of liver sinusoidal endothelial cells in cirrhotic rats were obtained. The screening was performed according to P < 0.01 and differential multiple factor ≥ 4. The obtained genes were input into the DAVID database for enrichment analysis of genes and pathways. The GeneMania and string databases were then used for protein interaction analysis. <strong>Results:</strong> The GSE1843 dataset was obtained in the GEO database, and three pathways significantly associated with cirrhosis and 13 differential genes enriched in three pathways were screened. Text mining revealed that 11 differential genes were directly associated with cirrhosis. The other two were indirectly linked by other genes. The screened genes and known gene formation networks were discovered by the GeneMania tool. <strong>Conclusion:</strong> CDH2 and COL1A1 may be important target genes for cirrhosis.
基金National Key Research and Development Program of China(Grant No.2017YFD0700800)National Science Foundation of China(Grant Nos.51775512,51575496)Zhejiang Provincial Natural Science Foundation of China(Grant No.LZ16E050003).
文摘It has been challenging to design seedling pick-up mechanism based on given key points and trajectories,because it involves dimensional synthesis and rod length optimization.In this paper,the dimensional synthesis of seedling pickup mechanism with planetary gear train was studied based on the data of given key points and the trajectory of the endpoint of seedling pick-up mechanism.Given the positions and orientations requirements of the five key points,the study first conducted a dimensional synthesis of the linkage size and center of rotation.The next steps were to select a reasonable solution and optimize the data values based on the ideal seedling trajectory.The link motion was driven by the planetary gear train of the two-stage gear.Four pitch curves of noncircular gears were obtained by calculating and distributing the transmission ratio according to the data.For the pitch curve with two convex points,the tooth profile design method of incomplete noncircular gear was applied.The seedling pick-up mechanism was tested by a virtual prototype and a physical prototype designed with the obtained parameter values.The results were consistent with the theoretical design requirements,confirming that the mechanism meets the expected requirements for picking seedlings up.This paper presents a new design method of vegetable pot seedling pick-up mechanism for an automatic vegetable transplanter.
基金Supported by the National Key Research and Development Program of China(Grant No.2017YFD0700800)National Natural Science Foundation of China(Grant Nos.51775512,51975536)+1 种基金Zhejiang Provincial Natural Science Foundation of China(Grant No.LQ20E050003)Basic Public Welfare Technology Application Research Projects of Zhejiang Province(Grant Nos.LGN19E050002,LGN20E050006).
文摘The current automatic scallion-transplanting machine is a complicated mechanism composed of two linkage mechanisms and two band carriers.It delivers seedlings ine ciently because of the movement limitations of the linkage mechanism.This paper proposes a new high-order non-circular gear train for an automatic scallion-seedling feeding mechanism.The proposed gear train has an asymmetrical transmission ratio;i.e.,its transmission ratio varies.This allows the mechanism’s execution component to move in a long displacement and rotate in a large rotation angle.The long displacement enables the execution component to reach the designed working position,and the large rotation angle allows it to feed a scallion in the required pose.A mathematical model for calculating the asymmetrical transmission ratio was established according to the closure requirements and the full-cycle motion of the driven gear pitch curve.Then,the parameter-design model of the new seedling-feeding mechanism was established,based on precise pose points and trajectory-shape control points.Moreover,an aided-design program was developed to obtain the parameter-solution domain of the scallion-seedling feeding mechanism.The mechanism parameters,which met the seedling-feeding function,were optimized to determine the transmission ratio,using a program and a kinematic simulation.Finally,a prototype of the mechanism was produced,and a seedling-feeding experiment was carried out.One-thousand seedlings were tested at a rate of 100 seedlings per minute,and the statistical success rate was 93.4%.Thus,the automatic scallion-seedling feeding mechanism significantly improves the e ciency of automatically transplanting scallions.
基金financial support from Industry Base Project supported by Ministry of Industry and Information Technology(0714-EMTC02-5593/13)Scientific Research and Development of Henan province(174200510014)。
文摘Ultra-high-purity silicon tetrachloride(SiCl4)is demanded as an electronic-grade chemical to meet the stringent requirements of the rapidly developing semiconductor industry.The high requirement for ultra-high-purity SiCl4 has created the need for a high-efficient process for reducing energy consumption as well as satisfying product quality.In this paper,a mass of production technology of ultra-high-purity SiCl4 was successfully developed through chlorination reaction in the ultraviolet(UV)-based photo microreactor coupled with the distillation process.The influences of key operational parameters,including temperature,pressure,UV wavelength and light intensity on the product quality,especially for hydrogen-containing impurities,were quantified by the infrared transmittance of Fourier transform infrared spectroscopy(FT-IR)at 2185 cm^-1and 2160 cm^-1indicating that chara cteristic vib rational modes of Si-H bonds,as well as the operating conditions of distillation were also investigated as key factors for metal impurities removing.The advanced intensification of SiCl4 manufactured by the integration of photo microreactor and distillation achieves the products with superior specifications higher than the standard commercial products.
基金supported by the National Natural Science Foundation of China,No.41874001 and No.41664001
文摘The elements of Green function matrix are the nonlinear functions of fault parameters estimation, the randomness of fault parameters estimation causes that the slip distribution inversion turns to be the parameter estimation problem of total least squares. Second-order approaching function method, scaled unscented transformation(SUT) method and adaptive Monte Carlo method are designed for biases of displacements in rectangular dislocation model. They are used to analyze effects of the length, width,depth and dip of fault with different variances on the corresponding displacements of unit strike slip dislocation fault, unit dip slip dislocation fault and unit tensile dislocation fault. Results of the simulated fault show that compared with second-order approaching function method and adaptive Monte Carlo method, SUT method has better computational efficiency. The second-order term has dominant effects on nonlinear relationship between displacements and the fault parameter in the rectangular dislocation model. The main biases of displacements are near to fault. The corresponding displacements of unit tensile dislocation are mostly susceptible to fault parameters estimation, followed by the unit dip slip dislocation and unit strike slip dislocation. In addition, the vertical displacement is more sensitive to fault parameters estimation than horizontal displacements.
基金National Natural Science Foundation of China(Nos.4187400141664001)+1 种基金Support Program for Outstanding Youth Talents in Jiangxi Province(No.20162BCB23050)National Key Research and Development Program(No.2016YFB0501405)。
文摘For the determination of the smoothing factor (also known as the regularization parameter) in the co-seismic slip distribution inversion, the compromise curve between the model roughness and the data fitting residual is generally used to determine (in order to distinguish the method proposed in this paper, the method is called “L curve” according to its shape). Based on the L-curve, the Eclectic Intersection curve as a new method is proposed to determine the smoothing factor in this paper. The results of the simulated experiment show that the inversion accuracy of the parameters of the seismic slip distribution with the smoothing factor determined by the Eclectic Intersection curve method is better than that of the L curve method. Moreover, the Eclectic Intersection curve method and the L curve method are used to determine the smoothing factor of L’Aquila earthquake and the Taiwan Meinong earthquake slip distribution inversion respectively, and the inversion results are compared and analyzed. The analysis results show that the L’Aquila and the Taiwan Meinong actual earthquake slip distribution results are in the range of other scholars at home and abroad, and compared with the L curve method, the Eclectic Intersection curve method has advantages of high computation efficiency, no need to depend on data fitting degree and more appropriate of smoothing factor and so on.
