明清之际西学东渐的历史反思

明清之际的西学东渐是中国历史上首次与西方文化的接触,这次西学东渐推动了中国文化的发展,但最终以失败而告终。本文从西学传入、西学中源说、罗马梵蒂冈教廷与清政府的礼仪之争等方面,对这次西学东渐做了一个历史性的总结与反思。

Research status of the mechanism and treatment for acute pancreatitis complicated with hepatic injury

Acute pancreatitis（AP） is characterized by its sudden onset and rapid progression and is often complicated by liver injury. APinduced liver injury may develop into hepatic failure and even result in death. Thus, it is of importance to protect liver function and block injury-related pathways. In the pathogenesis of liver injury in AP, inflammatory cytokines, nuclear factor-kappa B（NF- κB） and oxygen free radicals play important roles. The complexity of the mechanism underlying the development of liver injury exerts, to some extent, a contribution to the difficulties in the treatment of this disease. Currently, the drugs used to treat the disease include L-arginine （L-Arg）, calcium ion antagonists, somatostatin and a variety of inflammatory mediator inhibitors. Additionally, some traditional Chinese medicines such as tfipterygium, wilfordii, rhubarb and salvia milfiorrhizae may also have some effects. In this article, the pathogenesis of liver injury in AP and its therapy are reviewed.

The mechanisms in treatment of acute pancreatitis by traditional Chinese medicine

As common acute abdomen, most of acute pancreatifis（AP） are self-restricted. Only a few patients may develop into worse state with local complications or organ failures, and finally neastic acute pancreatitis （NAP）. With the change of people＇s dietaries, cholelithiasis morbidity and popularization of wine in recent years, the number of AP patients has increased. Although people conducted enormous studies on pathogenesis of AP and brought forward many be valuable theories, yet the exact mechanism is still unclear by far. There are many therapies of AP which should be unexceptionally classified as operative therapy and non-operative therapy. With the increasing understanding of the disease in recent years, we found many defects of operation and good therapeutic effects of traditional Chinese medicine in AP. Traditional Chinese medicine as an auxiliary therapy has been generally paid close attention in clinical practices. Traditional Chinese medicine is a treasure-house of China. This article summarizes the main mechanisms of AP treatment by traditional Chinese medicine and the progress of laboratory studies. It aims to help people recognize the multiple-target treatment effects and conspicuous efficacy of traditional Chinese medicine and promote the popularization of traditional Chinese medicine in AP treatment.

矩形钢丝环扎联合8字钢丝张力带与传统克氏针钢丝张力带对治疗髌骨横形骨折的早中期疗效比较

目的对比研究矩形钢丝环扎联合8字钢丝张力带与传统克氏针钢丝张力带两种不同内固定方式治疗髌骨骨折的早中期疗效。方法回顾性分析株洲市中心医院创伤骨科2020年1月至2022年6月收治的28例髌骨骨折患者资料,15例行矩形钢丝环扎联合8字钢丝张力带固定(为观察组),13例行传统克氏针钢丝张力带固定(为对照组)。记录两组手术时间、术中出血量、骨折愈合时间、术后内固定刺激率及术后18个月随访时膝关节疗效评定(采用Lysholm标准)。结果观察组与对照组在年龄、性别、术中出血量、骨折愈合时间、术后18个月随访时膝关节疗效评定差异无统计学意义(P>0.05),但观察组的手术时间更短,内固定刺激率更低,与对照组之间差异有统计学意义(P<0.05)。结论髌骨骨折采取矩形钢丝环扎加8字钢丝张力带可取得与传统克氏针钢丝张力带相同的预后效果,但其手术时间更短,可以更好避免内固定刺激发生,值得在临床工作中推广应用。

Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer

Sentinel lymph nodes(SLNs)are the first station of lymph nodes that extend from the breast tumor to the axillary lymphatic drainage.The pathological status of these LNs can predict that of the entire axillary lymph node.Therefore,the accurate identification of SLNs is necessary for sentinel lymph node biopsy(SLNB)to replace axillary lymph node dissection(ALND).The quality of life and prognosis of breast cancer patients are related to proper surgical treatment after the precise identification of SLNs.Some of the SLN tracers that have been identified include radioisotope,nano-carbon,indocyanine green(ICG),and methylene blue(MB).However,these tracers have certain limitations,such as pigmentation,radiation dangers,and the requirement for costly detection equipment.Ultrasound contrast agents(UCAs)have good specificity and sensitivity,and thus can compensate for some shortcomings of the mentioned tracers.This technique is also being applied to SLNB in patients with breast cancer,and can even provide an initial judgment on SLN status.Contrast-enhanced ultrasound(CEUS)has the advantages of high distinguishability,simple operation,no radiation harm,low cost,and accurate localization;therefore,it is expected to replace the traditional biopsy methods.In addition,it can significantly enhance the accuracy of SLN localization and shorten the operation time.

Roles of lncRNA in the diagnosis and prognosis of triple-negative breast cancer

Breast cancer is a malignant tumor that seriously endangers women's lives. The prognosis of breast cancer patients differs among molecular types. Compared with other subtypes, triple-negative breast cancer(TNBC) has been a research hotspot in recent years because of its high degree of malignancy, strong invasiveness, rapid progression, easy of recurrence,distant metastasis, poor prognosis, and high mortality. Many studies have found that long non-coding RNA(lncRNA) plays an important role in the occurrence, proliferation, migration, recurrence, chemotherapy resistance, and other characteristics of TNBC. Some lncRNAs are expected to become biomarkers in the diagnosis and prognosis of TNBC, and even new targets for its treatment. Based on a PubMed literature search, this review summarizes the progress in research on lncRNAs in TNBC and discusses their roles in TNBC diagnosis, prognosis, and chemotherapy with the hope of providing help for future research.

PERFORMANCE OF TROPICAL CYCLONE FORECAST IN WESTERN NORTH PACIFIC IN 2016

The forecasts of tropical cyclones(TC) in 2016 from 5 official guidances, 5 global models, 3 regional models and 6 ensemble systems were assessed to study the current capabilities of track and intensity forecasts for the western North Pacific. In 2016, the position errors for each official agency were under 85, 150 and 250 km at the lead times of 24, 48, and 72 h, respectively,indicating the performance of track forecasts was a little worse than that in 2015. For each lead time, decreases were seen for each quantile value of the global models from 2010 to 2015; however, this progress in forecasts was stagnated or was reversed in 2016, especially for long lead times.A new error tracking tool,called a "Track Error Rose",was used to visualize the spatial distributions of the track forecast error relative to the observed TC center. The results show that as lead time increases, the moving speed of most global model TC forecasts becomes slower than those of the observations, and the largest track error often appears to the south of the observation position. In 2016, JMA-GSM, NCEP-GFS, STI-GRAPES and UKMO-MetUM made considerable progress in their intensity forecasts at lead times of 24 and 48 h, and the EPS intensity forecasts made significant progress compared to those of 2015.

PERFORMANCE OF TROPICAL CYCLONE FORECAST IN WESTERN NORTH PACIFIC IN 2015

The operational track and intensity forecast errors of tropical cyclones(TCs) over the western North Pacific in 2015 were evaluated on the basis of RSMC-Tokyo's "best-track" dataset. The results showed that position errors for each official agency were under 80 km, 130 km, 180 km, 260 km and 370 km at 24, 48, 72, 96 and 120 hr lead time. Stepped decreases in the values of each quantile were made at every lead times and have been made by global models from 2010 to 2015, especially for long lead time. The results of the Track Forecast Integral Deviation(TFID) show a clearly decreasing trend for most global models, indicating that the TC forecast tracks became increasingly similar to the observations. In 2015, the intensity forecast skill scores for both global and regional models were almost negative. However, the skill of EPSs' intensity forecasting has made significant progress in the past year.

The impact of Typhoon Lekima (2019) on East China: a postevent survey in Wenzhou City and Taizhou City

Typhoon Lekima(2019)struck Zhejiang Province on 10 August 2019 as a supertyphoon,which severely impacted Zhejiang Province.The typhoon killed 45 people and left three others missing,and the total economic loss reached 40.71 billion yuan.This paper reports a postdisaster survey that focuses on the storm precipitation,flooding,landslides,and weather services associated with Typhoon Lekima(2019)along the southeastern coastline of Zhejiang Province.The survey was conducted by a joint survey team from the Shanghai Typhoon Institute and local meteorological bureaus from 26 to 28 August,2019,approximately two weeks after the disaster.Based on this survey and subsequent analyses of the results,we hope to develop countermeasures to prevent future tragedies.

VERIFICATION OF ENSEMBLE TRACK FORECASTS OF TROPICAL CYCLONES DURING 2014

The track forecasts of fi ve ensemble prediction systems(JMA-WEPS,CMA-GEFS,ECMWF-EPS,NCEP-GEFS and MSC-CENS,respectively)in 2014 are evaluated in this paper.First,on the assumption of bivariate normal distribution,a probability ellipse based on ensemble spread is proposed to represent forecast uncertainties,and then the ellipse and ensemble mean are used to evaluate the fi ve different systems.It is found that the probability ellipse of ECMWF-EPS is smaller,with a high hit ratio,and its mean track errors are just a little larger than those of NCEP-GEFS within 48 h,meaning overall it outperforms the other four systems.Meanwhile,the performance of CMA-GEFS is found to be the poorest.

Performance of tropical cyclone forecasts in the western North Pacific in 2017

The forecasts of tropical cyclones(TC)in 2017 from five official guides,six global models,six regional models and six ensemble systems were assessed to study the current capability of track and intensity forecasts for the western North Pacific.The results show that the position errors for official agencies were under 100,165,265,335 and 425 km at the lead times of 24,48,72,96 and 120 h,respectively.As the forecast lead times increased,the forecasted TCs propagated,on average,too slow for most official guides.It is encouraging to note that all the models had positive skill scores,there is an overall upward trend in the skill scores of the models during from 2010 to 2017.Furthermore,both global and regional models’intensity forecast skill was increasing year by year from 2010 to 2017.For the ensemble prediction systems(EPSs),ECMWF-EPS was the best forecast system for the lead time less than 72 h,beyond the 72 h,the best EPS belong to NCEP-GEFS.

Evaluation of forecast performance for Super Typhoon Lekima in 2019

The predictions for Super Typhoon Lekima(2019)have been evaluated from official forecasts,global models,regional models and ensemble prediction systems(EPSs)at lead times of 1–5 days.Track errors from most deterministic forecasts are smaller than their annual mean errors in 2019.Compared to the propagation speed,the propagation direction of Lekima(2019)was much easier to determine for the official agency and numerical weather prediction(NWP)models.The National Centers for Environmental Prediction Global Ensemble Forecast System(NCEP-GEFS),Japan Meteorological Agency Global Ensemble Prediction System(JMA-GEPS)and Meteorological Service of Canada Ensemble System(MSC-CENS)are underdispersed,and the Shanghai Typhoon Institute Typhoon Ensemble Data Assimilation and Prediction System(STI-TEDAPS)is overdispersed,while the ensemble prediction system from European Centre for Medium-Range Weather Forecasts(ECMWF)shows adequate dispersion at all lead times.Most deterministic forecasting methods underestimated the intensity of Lekima(2019),especially for the rapid intensification period after Lekima(2019)entered the East China Sea.All of the deterministic forecasts performed well at predicting the first landfall point at Wenling,Zhejiang Province with a lead time of 24 and 48 h.