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Precise nanomedicine for intelligent therapy of cancer 被引量:21
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作者 Huabing Chen Zhanjun Gu +39 位作者 Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao jiang Hengte Ke xiqun jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao 《Science China Chemistry》 SCIE EI CAS CSCD 2018年第12期1503-1552,共50页
Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the... Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. 展开更多
关键词 NANOMEDICINE NANOPARTICLES CANCER THERAPY CANCER imaging INTELLIGENT THERAPY
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Biomedical polymers: synthesis, properties, and applications 被引量:4
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作者 Wei-Hai Chen Qi-Wen Chen +34 位作者 Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji xiqun jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen 《Science China Chemistry》 SCIE EI CSCD 2022年第6期1010-1075,共66页
Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, ... Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. 展开更多
关键词 biomedical polymer NANOMEDICINE cancer therapy drug delivery bioimaging and biosensing tissue engineering regenerative medicine cytotoxicity BIOCOMPATIBILITY
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Shape Effects of Cylindrical versus Spherical Unimolecular Polymer Nanomaterials on in Vitro and in Vivo Behaviors 被引量:2
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作者 Zhengkui Zhang Changren Liu +2 位作者 Cheng Li Wei Wu xiqun jiang 《Research》 EI CAS 2019年第1期1019-1031,共13页
To date,how the shape of nanomaterials infuences their biological properties is poorly understood,due to the insufcient controllability of current preparative methods,especially in the shape and size of nanomaterials.... To date,how the shape of nanomaterials infuences their biological properties is poorly understood,due to the insufcient controllability of current preparative methods,especially in the shape and size of nanomaterials.In this paper,we achieved the precise syntheses of nanoscale unimolecular cylindrical polymer brushes(CPBs)and spherical polymer nanoparticles(SPNPs)with the same volume and surface chemistry,which ensured that shape was essentially the only variable when their biological performance was compared.Accurate shape efects were obtained.Impressively,the CPBs had remarkable advantage in tissue penetration over the SPNPs.Te CPBs also exhibited higher cellular uptake and rapider body clearance than the SPNPs,whereas the SPNPs had longer blood circulation time,rapider tumor vascular extravasation,and higher tumor accumulation than the CPBs.Additionally,this work also provided a controllable synthesis strategy for nanoscale unimolecular SPNPs by integrating 21 CPBs to a�-cyclodextrin core,whose diameter in dry state could be up to 45 nm. 展开更多
关键词 materials integrating CYLINDRICAL
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Responsive boron biomaterials and their biomedical applications 被引量:1
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作者 Weizhi Chen Xu Zhen +1 位作者 Wei Wu xiqun jiang 《Science China Chemistry》 SCIE EI CAS CSCD 2020年第5期648-664,共17页
Due to the formation of dynamic boronate ester bonds between phenylboronic acid(PBA) and 1,2-and 1,3-diols, PBAcontaining biomaterials show increasing applications in biomedical areas, including responsive nanobiomate... Due to the formation of dynamic boronate ester bonds between phenylboronic acid(PBA) and 1,2-and 1,3-diols, PBAcontaining biomaterials show increasing applications in biomedical areas, including responsive nanobiomaterials for targeting delivery of chemical drugs, protein drugs, gene drugs and imaging agents in vitro and in vivo for detection of various bioactive molecules such as sialic acid, saccharides, adenosine triphosphate(ATP) and dopamine. With the specific reaction between PBA and sialic acid, which is overexpressed in many kinds of cancer cells, PBA has been used as a targeting moiety for tumortargeting drug delivery. Additionally, PBA as an electron acceptor affords nanomaterials Lewis acid-base coordination with electron donor atoms such as nitrogen and oxygen, which can be exploited for developing drug delivery systems with high drug loading. Furthermore, PBA-containing materials can stoichiometric consume reactive oxygen species(ROS) and show a nucleus targeting ability. This current review outlined PBA-containing biomaterials with various responsive abilities including sialic acid-targeting, sugars-binding, ROS-response, ATP-response, dopamine-binding, and nuclear targeting. On this basis, their biomedical applications were summarized. 展开更多
关键词 responsive biomaterials phenylboronic acid drug delivery system biomedical application
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Entrapping multifunctional dendritic nanoparticles into a hydrogel for local therapeutic delivery and synergetic immunochemotherapy 被引量:5
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作者 Lei jiang Yang Ding +4 位作者 Xialin Xue Sensen Zhou Cheng Li Xiaoke Zhang xiqun jiang 《Nano Research》 SCIE EI CAS CSCD 2018年第11期6062-6073,共12页
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Nanoscale Crystalline Sheets and Vesicles Assembled from Nonplanar Cyclic π-Conjugated Molecules
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作者 Huang Tang Zhewei Gu +4 位作者 Haifeng Ding Zhibo Li Shiyan Xiao Wei Wu xiqun jiang 《Research》 EI CAS 2019年第1期761-771,共11页
A fundamental challenge in chemistry and materials science is to create new carbon nanomaterials by assembling structurally unique carbon building blocks,such as nonplanar π-conjugated cyclic molecules.However,self-a... A fundamental challenge in chemistry and materials science is to create new carbon nanomaterials by assembling structurally unique carbon building blocks,such as nonplanar π-conjugated cyclic molecules.However,self-assembly of such cyclic π-molecules to form organized nanostructures has been rarely explored despite intensive studies on their chemical synthesis.Here we synthesized a family of new cycloparaphenylenes and found that these fully hydrophobic and nonplanar cyclic π-molecules could self-assemble into structurally distinct two-dimensional crystalline multilayer nanosheets.Moreover,these crystalline multilayer nanosheets could overcome inherent rigidity to curve into closed crystalline vesicles in solution.Tese supramolecular assemblies show that the cyclic molecular scafolds are homogeneously arranged on the surface of nanosheets and vesicles with their molecular isotropic x-y plane standing obliquely on the surface.Tese supramolecular architectures that combined exact crystalline order,orientation-specifc arrangement of π-conjugated cycles,controllable morphology,uniform molecular pore,superior forescence quench ability,and photoluminescence are expected to give rise to a new class of functional materials displaying unique photonic,electronic,and biological functions. 展开更多
关键词 solution planar CRYSTALLINE
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Emerging Designs of Aggregation-Induced Emission Agents for Enhanced Phototherapy Applications
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作者 Rui Qu Xu Zhen xiqun jiang 《CCS Chemistry》 CAS 2022年第2期401-419,共19页
Phototherapy,including photodynamic therapy(PDT)and photothermal therapy(PTT),that employs phototherapeutic agents to generate cytotoxic reactive oxygen species(ROS)or hyperthermia,is a promising approach for disease ... Phototherapy,including photodynamic therapy(PDT)and photothermal therapy(PTT),that employs phototherapeutic agents to generate cytotoxic reactive oxygen species(ROS)or hyperthermia,is a promising approach for disease therapy.However,conventional organic phototherapeutic agents suffer poor photostability and aggregation-caused quenching(ACQ)in the aggregate state,restricting their therapeutic efficacy.Aggregation-induced emission(AIE)agents can solve these issues with strong emission in the aggregate state and reverse designation to generate heat.This review summarizes the recent advances in the development of AIE phototherapy agents for enhanced PDT and PTT performances in biomedical applications.First,design strategies of AIE agents that adjust the intersystem crossing process or intramolecular charge transfer to boost ROS generation or regulate ROS types are discussed.The AIE agents with ROS generation ability for biomedical applications including antitumor and antibacterial performances are then introduced.Next,designs and examples of AIE agents that enhance PTT performances through molecular motions are described.Finally,the current challenges and perspectives of AIE agents in the phototherapy field are discussed. 展开更多
关键词 aggregation-induced emission structural designing PHOTOTHERAPY photodynamic therapy photothermal therapy
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Self-Assembly of Crystalline Vesicles from Nonplanarπ-Conjugated Nanocycles
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作者 Huang Tang Zhewei Gu +3 位作者 Chengyang Qiao Zhibo Li Wei Wu xiqun jiang 《CCS Chemistry》 CAS 2021年第7期1851-1861,共11页
There is a great demand for self-assembled carbon nanomaterials because of their importance in optoelectronics,biomaterials,and so forth.Herein,we report a novel type of self-assembled,nanoscale,crystalline vesicle fr... There is a great demand for self-assembled carbon nanomaterials because of their importance in optoelectronics,biomaterials,and so forth.Herein,we report a novel type of self-assembled,nanoscale,crystalline vesicle from nonplanarπ-conjugated nanocycles.We designed four different structural[8]cycloparaphenylenes([8]CPPs)molecules and demonstrated that these nonplanarπ-conjugated CPP nanocycles could self-assemble into multilamellar,crystalline vesicles in tetrahydrofuran(THF)/H2O mixed solvent. 展开更多
关键词 cycloparaphenylene VESICLE crystallization cell internalization SUPRAMOLECULE
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