Anopheles sinensis is a major malaria vector. Insect odorant-binding proteins （OBPs） may function in the reception of odorants in the olfactory system. The classification and characterization of the An. sinensis OBP...Anopheles sinensis is a major malaria vector. Insect odorant-binding proteins （OBPs） may function in the reception of odorants in the olfactory system. The classification and characterization of the An. sinensis OBP genes have not been systematically studied. In this study, 64 putative OBP genes were identified at the whole-genome level of An. sinensis based on the comparison between OBP conserved motifs, PBP_GOBE and phylogenetic analysis with An. gambiae OBPs. The characterization of An. sinensis OBPs, including the motifs conservation, gene structure, genomic organization and classification, were investigated. A new gene, AsOBP73, belonging to the Plus-C subfamily, was identified with the support of transcript and conservative motifs. These An. sinensis OBP genes were classified into three subfamilies with 37, 15 and 12 genes in the subfamily Classic, Atypical and Plus-C, respectively. The genomic organization of An. sinensis OBPs suggests a clustered distribution across nine different scaffolds. Eight genes （0BP23-28, 0BP63- 64） might originate from a single gene through a series of historic duplication events at least before divergence of Anopheles, Culex and Aedes. The microsynteny analyses indicate a very high synteny between An. sinensis and An. gambiae OBPs. OBP70 and OBP71 earlier classified under Plus-C in An. gambiae are recognized as belonging to the group Obp59a of the Classic subfamily, and OBP69 earlier classified under Plus-C has been moved to the Atypical subfamily in this study. The study established a basic information frame for further study of the OBP genes in insects as well as in An. sinensis.展开更多
The sensing characteristics of irradiated fiber Bragg gratings(FBGs)and Fabry-Perot interferometers(FPIs)were investigated under a 2MGy dose of gamma radiation.The study found that the pressure sensitivity of FP senso...The sensing characteristics of irradiated fiber Bragg gratings(FBGs)and Fabry-Perot interferometers(FPIs)were investigated under a 2MGy dose of gamma radiation.The study found that the pressure sensitivity of FP sensors after irradiation was stable,while the temperature sensitivity of FBG sensors was unstable,and both wavelengths displayed a shift.These findings offer the possibility for the application of FP pressure sensors in the gamma radiation environments,and FBG sensors require further research to be suitable for application in the nuclear radiation environments.展开更多
A fiber-optic Raman spectrum sensor system is used for the fast diagnosis of esophageal cancer during clinical endoscopic examination.The system contains a 785nm exciting laser,a Raman fiber-optic probe with 7 large c...A fiber-optic Raman spectrum sensor system is used for the fast diagnosis of esophageal cancer during clinical endoscopic examination.The system contains a 785nm exciting laser,a Raman fiber-optic probe with 7 large core fibers and a focus lens,and a highly sensitive spectrum meter.The Raman spectrum of the tissue could be obtained within 1 second by using such a system. A signal baseline removal and denoising technology is used to improve the signal quality.A novel signal feature extraction method for differentiating the normal and esophageal cancer tissues is proposed,based on the differences in half-height width(HHW)in 1200cm^-1 to 1400cm^-1 frequency band and the ratios of the spectral integral energy between 1600cm^-1-1700cm^-1 and 1500cm^-1- 1600cm^-1 band.It shows a high specificity and effectivity for the diagnosis of esophageal cancer.展开更多
This paper reviews a wide variety of fiber-optic microstructure(FOM)sensors,such as fiber Bragg grating(FBG)sensors,long-period fiber grating(LPFG)sensors,Fabry-Perot interferometer(FPI)sensors,Mach-Zchnder interferom...This paper reviews a wide variety of fiber-optic microstructure(FOM)sensors,such as fiber Bragg grating(FBG)sensors,long-period fiber grating(LPFG)sensors,Fabry-Perot interferometer(FPI)sensors,Mach-Zchnder interferometer(MZI)sensors,Michelson interferometer(MI)sensors,and Sagnac interferometer(SI)sensors.Each FOM sensor has been introduced in the terms of structure types,fabrication methods,and their sensing applications.In addition,the sensing characteristics of different structures under the same type of FOM sensor are compared,and the sensing characteristics of the all FOM sensors,including advantages,disadvantages,and main sensing parameters,are summarized.We also discuss the future development of FOM sensors.展开更多
A length-matched micro Fabry-Perot(FP)interferometer is proposed for strain measurement under irradiation environment.Theoretical simulation shows that a well length-matched FP sensor can achieve a very low drift of t...A length-matched micro Fabry-Perot(FP)interferometer is proposed for strain measurement under irradiation environment.Theoretical simulation shows that a well length-matched FP sensor can achieve a very low drift of the cavity length and strain sensitivity in irradiation environment.In experiment,such an FP cavity is realized by laser micromachining.It shows a low cavity length drift of−0.037μm and a strain sensitivity deviation of 0.52%,respectively,under gamma irradiation.Meanwhile,the intensity of interference fringes is also stable.As a result,such a length-matched FP cavity is a very promising candidate for strain sensing in radiative environments.展开更多
基金Acknowledgments This research was supported by the following, Par-Eu Scholars Program, the National Natural Science Foundation of China （31372265, 31572332）, Coordinated Research Project of the International Atomic Energy Agency （18268/R0）, and National Key Program of Science and Technology Foundation Work of China （2015FY210300）. Conceived and designed the research： BC, XH. Performed the analysis： XH, BC, ZBH, YJZ, YZ, PJX, LQ. Wrote the paper： XH, BC, ZBH.
文摘Anopheles sinensis is a major malaria vector. Insect odorant-binding proteins （OBPs） may function in the reception of odorants in the olfactory system. The classification and characterization of the An. sinensis OBP genes have not been systematically studied. In this study, 64 putative OBP genes were identified at the whole-genome level of An. sinensis based on the comparison between OBP conserved motifs, PBP_GOBE and phylogenetic analysis with An. gambiae OBPs. The characterization of An. sinensis OBPs, including the motifs conservation, gene structure, genomic organization and classification, were investigated. A new gene, AsOBP73, belonging to the Plus-C subfamily, was identified with the support of transcript and conservative motifs. These An. sinensis OBP genes were classified into three subfamilies with 37, 15 and 12 genes in the subfamily Classic, Atypical and Plus-C, respectively. The genomic organization of An. sinensis OBPs suggests a clustered distribution across nine different scaffolds. Eight genes （0BP23-28, 0BP63- 64） might originate from a single gene through a series of historic duplication events at least before divergence of Anopheles, Culex and Aedes. The microsynteny analyses indicate a very high synteny between An. sinensis and An. gambiae OBPs. OBP70 and OBP71 earlier classified under Plus-C in An. gambiae are recognized as belonging to the group Obp59a of the Classic subfamily, and OBP69 earlier classified under Plus-C has been moved to the Atypical subfamily in this study. The study established a basic information frame for further study of the OBP genes in insects as well as in An. sinensis.
基金This work was funded by the National Science Foundation of China(NCSF)(Grant No.51875091)the Study and Application of Full-model Impact Dynamic Fretting Damage Test System in the Extreme Environment(Grant No.51627806)+3 种基金Research on Application of Optical Fiber Sensing in Nuclear Power(Grant No.180046)Optical Fiber Sensing and Processing Prototype for Nuclear Field Key Parameter Measurement(Grant No.191091)Data Acquisition and Post-processing Software Development for Integrated Fiber Optic Sensors(Grant No.190167)the State 111 Project(Grant No.B14039).
文摘The sensing characteristics of irradiated fiber Bragg gratings(FBGs)and Fabry-Perot interferometers(FPIs)were investigated under a 2MGy dose of gamma radiation.The study found that the pressure sensitivity of FP sensors after irradiation was stable,while the temperature sensitivity of FBG sensors was unstable,and both wavelengths displayed a shift.These findings offer the possibility for the application of FP pressure sensors in the gamma radiation environments,and FBG sensors require further research to be suitable for application in the nuclear radiation environments.
基金multicenter clinical study of endoscopic diagnosis of early esophageal cancer(Grant No.SWH2016ZDCX3007)the State 111 Project(Grant No.B14039)+3 种基金Application of endoscopic minimally invasive technique in diagnosis and treatment of digestive tract injury and disease(Grant No.SWH2016ZDCX2011)Study of effect on fibroblast transdifferentiation and prevention of postoperative esophagus stenosis through regulating the TRADD(Grant No. 81470907)the National Natural Science Foundation of China(NSFC)(Grant Nos.51627806and 51875091)Application of Raman imaging in the diagnosis of gastric cancer(Grant No. cstc2015shmszx 10017).
文摘A fiber-optic Raman spectrum sensor system is used for the fast diagnosis of esophageal cancer during clinical endoscopic examination.The system contains a 785nm exciting laser,a Raman fiber-optic probe with 7 large core fibers and a focus lens,and a highly sensitive spectrum meter.The Raman spectrum of the tissue could be obtained within 1 second by using such a system. A signal baseline removal and denoising technology is used to improve the signal quality.A novel signal feature extraction method for differentiating the normal and esophageal cancer tissues is proposed,based on the differences in half-height width(HHW)in 1200cm^-1 to 1400cm^-1 frequency band and the ratios of the spectral integral energy between 1600cm^-1-1700cm^-1 and 1500cm^-1- 1600cm^-1 band.It shows a high specificity and effectivity for the diagnosis of esophageal cancer.
基金funded by the National Natural Science Foundation of China(NCSF)(Grant Nos.51205049,51875091,and 51327806)the state 111 Project(Grant No.Bl4039).
文摘This paper reviews a wide variety of fiber-optic microstructure(FOM)sensors,such as fiber Bragg grating(FBG)sensors,long-period fiber grating(LPFG)sensors,Fabry-Perot interferometer(FPI)sensors,Mach-Zchnder interferometer(MZI)sensors,Michelson interferometer(MI)sensors,and Sagnac interferometer(SI)sensors.Each FOM sensor has been introduced in the terms of structure types,fabrication methods,and their sensing applications.In addition,the sensing characteristics of different structures under the same type of FOM sensor are compared,and the sensing characteristics of the all FOM sensors,including advantages,disadvantages,and main sensing parameters,are summarized.We also discuss the future development of FOM sensors.
基金This work was funded by the National Natural Science Foundation of China(Grant No.51875091)the Study and Application of Full-Model Impact Dynamic Fretting Damage Test System in the Extreme Environment(Grant No.51627806)+2 种基金Optical Fiber Sensing and Processing Prototype for Nuclear Field Key Parameter Measurement(Grant No.191091)Data Acquisition and Post-Processing Software Development for Integrated Fiber Optic Sensors(Grant No.190167)the State 111 Project(Grant No.B14039).
文摘A length-matched micro Fabry-Perot(FP)interferometer is proposed for strain measurement under irradiation environment.Theoretical simulation shows that a well length-matched FP sensor can achieve a very low drift of the cavity length and strain sensitivity in irradiation environment.In experiment,such an FP cavity is realized by laser micromachining.It shows a low cavity length drift of−0.037μm and a strain sensitivity deviation of 0.52%,respectively,under gamma irradiation.Meanwhile,the intensity of interference fringes is also stable.As a result,such a length-matched FP cavity is a very promising candidate for strain sensing in radiative environments.
