Stripe rust, caused by Puccinia striiformis f. sp. tritici(Pst), threatens wheat production worldwide, and resistant varieties tend to become susceptible after a period of cultivation owing to the variation of pathoge...Stripe rust, caused by Puccinia striiformis f. sp. tritici(Pst), threatens wheat production worldwide, and resistant varieties tend to become susceptible after a period of cultivation owing to the variation of pathogen races. In this study, a new resistance gene against Pst race CYR34 was identified and predicted using the descendants of a cross between AS1676, a highly resistant Chinese landrace, and Avocet S, a susceptible cultivar. From a heterozygous plant from a F7recombinant inbred line(RIL) population lacking the Yr18 gene, a near-isogenic line(NIL) population was developed to map the resistance gene. An allstage resistance gene, YrAS1676, was identified on chromosome arm 1AL via bulked-segregant exomecapture sequencing. By analyzing a large NIL population consisting of 6537 plants, the gene was further mapped to the marker interval between KA1A_485.36 and KA1A_490.13, spanning 485.36–490.13 Mb on1AL. A total of 66 annotated genes have been reported in this region. To characterize and predict the candidate gene(s), an RNA-seq was performed using NIL-R and NIL-S seedlings 3 days after CYR34 inoculation. Compared to NIL-S plants, NIL-R plants showed stronger immune reaction and higher expression levels of genes encoding pathogenesis-associated proteins. These differences may help to explain why NIL-R plants were more resistant to Pst race CYR34 than NIL-S plants. By combining fine-mapping and transcriptome sequencing, a calcium-dependent protein kinase gene was finally predicted as the potential candidate gene of YrAS1676. This gene contained a single-nucleotide polymorphism. The candidate gene was more highly expressed in NIL-R than in NIL-S plants. In field experiments with Pst challenge,the YrAS1676 genotype showed mitigation of disease damage and yield loss without adverse effects on tested agronomic traits. These results suggest that YrAS1676 has potential use in wheat stripe rust resistance breeding.展开更多
BACKGROUND Pulp revascularization is a novel way to treat immature teeth with periapical disease,and the technique has become increasingly well established in recent years.By puncturing the periapical tissue,bleeding ...BACKGROUND Pulp revascularization is a novel way to treat immature teeth with periapical disease,and the technique has become increasingly well established in recent years.By puncturing the periapical tissue,bleeding is induced,and a blood clot is formed in the root canal.The blood clot acts as a natural bioscaffold onto which mesenchymal stem cells from periapical tissue can be seeded and restore pulp vascularity,thus promoting root development as well as apical closure.Although the effect of pulp revascularization is ideal,there are certain requirements for the apical condition of the teeth.The apical barrier technique and apexification are still indispensable for teeth that cannot achieve ideal blood clot formation.In addition,a meta-analysis of several clinical studies concluded that pulp revascu-larization has no significant advantages over other treatments.CASE SUMMARY A 10-year-old girl complained of pain in the right upper and lower posterior teeth for 2 d.Clinical and radiological examinations revealed that both the right maxillary and mandibular second premolars were immature with periapical radiolucency.The right maxillary second premolar was treated by pulp revascu-larization,while the right mandibular second premolar was treated by conven-tional apical barrier surgery after revascularization failed.The purpose of this report is to compare the different root maturation processes induced by the pulp revascularization and apical barrier techniques in the same patient in homonymous teeth from different jaws.Twelve months of follow-up showed that the apical foramen of both teeth presented a clear tendency to close;however,the tooth treated with pulp revascularization showed a significant increase in root length as well as root canal wall thickness.CONCLUSION For the treatment of nonvital immature teeth,pulp revascularization showed a superior therapeutic effect in comparison with the apical barrier technique.展开更多
1.Introduction 2020 is an unusual year in which the COVID-19 pandemic has raged through the globe,infecting tens of millions of people and killing hundreds of thousands.The pandemic has not only wreaked havoc on publi...1.Introduction 2020 is an unusual year in which the COVID-19 pandemic has raged through the globe,infecting tens of millions of people and killing hundreds of thousands.The pandemic has not only wreaked havoc on public health systems,economic activities,and people's lives,but also has greatly affected and will continue to reshape the world's political,economic,and trade patterns.展开更多
In order to make an intensive study of the development of smart power distribution and utilization technology in China, their research hotspots and frontier technology are selected out through combining the informatic...In order to make an intensive study of the development of smart power distribution and utilization technology in China, their research hotspots and frontier technology are selected out through combining the informatics method, and using the CiteSpace which can take keyword cooccurrence analysis and draw the visualization graph. According to this result, we can infer the development trend of smart power distribution and utilization in the future, and providing reference for the researcher whose engage in this domain. The electric related literature was collected from the CNKI database in China. Under the smart power distribution and utilization domain, we also analyze the development of the power quality and the energy internet in detail.展开更多
Gaussian process(GP)regression is a flexible non-parametric approach to approximate complex models.In many cases,these models correspond to processes with bounded physical properties.Standard GP regression typically r...Gaussian process(GP)regression is a flexible non-parametric approach to approximate complex models.In many cases,these models correspond to processes with bounded physical properties.Standard GP regression typically results in a proxy model which is unbounded for all temporal or spacial points,and thus leaves the possibility of taking on infeasible values.We propose an approach to enforce the physical constraints in a probabilistic way under the GP regression framework.In addition,this new approach reduces the variance in the resulting GP model.展开更多
The strong chiroptical effect is highly desirable and has a wide range of applications in biosensing, chiral catalysis,polarization tuning, and chiral photo detection. In this work, we find a simple method to enhance ...The strong chiroptical effect is highly desirable and has a wide range of applications in biosensing, chiral catalysis,polarization tuning, and chiral photo detection. In this work, we find a simple method to enhance the reflection circular dichroism(CDR) by placing the planar anisotropic chiral metamaterials(i.e., Z-shaped PACMs) on the interface of two media(i.e., Z-PCMI) with a large refractive index difference. The maximum reflection CDR from the complex system can reach about 0.840 when the refractive index is set as ntop = 4.0 and nbottom = 1.49, which is approximately three times larger than that of placing the Z-shaped PACMs directly on the substrate(i.e., Z-PCMS). While the minimum reflection CDR is 0.157 when the refractive index is set as ntop = 1.0 and nbottom = 1.49. So we can get a large available range of reflection CDR from -0.840 to -0.157. Meanwhile, the transmission CDT remains unchanged with the refractive index ntop increment. Our in-depth research indicates that the large reflection CDR is derived from the difference of non-conversion components of the planar anisotropic chiral metamaterials’ reflection matrices. In short, we provide a simple and practical method to enhance the chiroptical effect by changing the refractive index difference between two media without having to design a complex chiral structure.展开更多
Multi-energy flow (MEF) coupling is one of the key features of the energy Internet and integrated energy systems that are different from smart grids. With the increasing coupling of heterogeneous energy flow, the syst...Multi-energy flow (MEF) coupling is one of the key features of the energy Internet and integrated energy systems that are different from smart grids. With the increasing coupling of heterogeneous energy flow, the system characteristics of coupling are becoming more and more obvious and more complicated. The modeling, analysis and control methods of traditional single flow systems have not been applied directly. Therefore, it is necessary to study the modeling of multi-energy flow coupling, the power flow analysis, optimization and control method of heterogeneous energy flow, which plays the role of multi-energy flow synergy to avoid the adverse effects of coupling. This paper summarizes the current research situation of energy Internet at home and abroad from the aspects of modeling of multi-energy flow, power flow calculation and optimal dispatching, and analyzes the existing problems in the research of these aspects.展开更多
基金supported by the Major Program of National Agricultural Science and Technology of China (NK20220607)the National Natural Science Foundation of China (32272059 and31971883)the Science and Technology Department of Sichuan Province (2022ZDZX0014, 2021YFYZ0002, 2021YJ0297, and23NSFTD0045)。
文摘Stripe rust, caused by Puccinia striiformis f. sp. tritici(Pst), threatens wheat production worldwide, and resistant varieties tend to become susceptible after a period of cultivation owing to the variation of pathogen races. In this study, a new resistance gene against Pst race CYR34 was identified and predicted using the descendants of a cross between AS1676, a highly resistant Chinese landrace, and Avocet S, a susceptible cultivar. From a heterozygous plant from a F7recombinant inbred line(RIL) population lacking the Yr18 gene, a near-isogenic line(NIL) population was developed to map the resistance gene. An allstage resistance gene, YrAS1676, was identified on chromosome arm 1AL via bulked-segregant exomecapture sequencing. By analyzing a large NIL population consisting of 6537 plants, the gene was further mapped to the marker interval between KA1A_485.36 and KA1A_490.13, spanning 485.36–490.13 Mb on1AL. A total of 66 annotated genes have been reported in this region. To characterize and predict the candidate gene(s), an RNA-seq was performed using NIL-R and NIL-S seedlings 3 days after CYR34 inoculation. Compared to NIL-S plants, NIL-R plants showed stronger immune reaction and higher expression levels of genes encoding pathogenesis-associated proteins. These differences may help to explain why NIL-R plants were more resistant to Pst race CYR34 than NIL-S plants. By combining fine-mapping and transcriptome sequencing, a calcium-dependent protein kinase gene was finally predicted as the potential candidate gene of YrAS1676. This gene contained a single-nucleotide polymorphism. The candidate gene was more highly expressed in NIL-R than in NIL-S plants. In field experiments with Pst challenge,the YrAS1676 genotype showed mitigation of disease damage and yield loss without adverse effects on tested agronomic traits. These results suggest that YrAS1676 has potential use in wheat stripe rust resistance breeding.
基金Supported by The Natural Science Foundation of Shaanxi Province,China,No.2022JM-447.
文摘BACKGROUND Pulp revascularization is a novel way to treat immature teeth with periapical disease,and the technique has become increasingly well established in recent years.By puncturing the periapical tissue,bleeding is induced,and a blood clot is formed in the root canal.The blood clot acts as a natural bioscaffold onto which mesenchymal stem cells from periapical tissue can be seeded and restore pulp vascularity,thus promoting root development as well as apical closure.Although the effect of pulp revascularization is ideal,there are certain requirements for the apical condition of the teeth.The apical barrier technique and apexification are still indispensable for teeth that cannot achieve ideal blood clot formation.In addition,a meta-analysis of several clinical studies concluded that pulp revascu-larization has no significant advantages over other treatments.CASE SUMMARY A 10-year-old girl complained of pain in the right upper and lower posterior teeth for 2 d.Clinical and radiological examinations revealed that both the right maxillary and mandibular second premolars were immature with periapical radiolucency.The right maxillary second premolar was treated by pulp revascu-larization,while the right mandibular second premolar was treated by conven-tional apical barrier surgery after revascularization failed.The purpose of this report is to compare the different root maturation processes induced by the pulp revascularization and apical barrier techniques in the same patient in homonymous teeth from different jaws.Twelve months of follow-up showed that the apical foramen of both teeth presented a clear tendency to close;however,the tooth treated with pulp revascularization showed a significant increase in root length as well as root canal wall thickness.CONCLUSION For the treatment of nonvital immature teeth,pulp revascularization showed a superior therapeutic effect in comparison with the apical barrier technique.
基金Thanks for the support of the Special Fund for Global Green Development and Climate Change of Tsinghua University Education Foundation and the Energy Foundation.
文摘1.Introduction 2020 is an unusual year in which the COVID-19 pandemic has raged through the globe,infecting tens of millions of people and killing hundreds of thousands.The pandemic has not only wreaked havoc on public health systems,economic activities,and people's lives,but also has greatly affected and will continue to reshape the world's political,economic,and trade patterns.
文摘In order to make an intensive study of the development of smart power distribution and utilization technology in China, their research hotspots and frontier technology are selected out through combining the informatics method, and using the CiteSpace which can take keyword cooccurrence analysis and draw the visualization graph. According to this result, we can infer the development trend of smart power distribution and utilization in the future, and providing reference for the researcher whose engage in this domain. The electric related literature was collected from the CNKI database in China. Under the smart power distribution and utilization domain, we also analyze the development of the power quality and the energy internet in detail.
基金supported by Simons Foundationsupported by the U.S. Department of Energy Office of Science, Office of Advanced Scientific Computing Research as part of Physics-Informed Learning Machines for Multiscale and Multiphysics Problems (PhILMs)
文摘Gaussian process(GP)regression is a flexible non-parametric approach to approximate complex models.In many cases,these models correspond to processes with bounded physical properties.Standard GP regression typically results in a proxy model which is unbounded for all temporal or spacial points,and thus leaves the possibility of taking on infeasible values.We propose an approach to enforce the physical constraints in a probabilistic way under the GP regression framework.In addition,this new approach reduces the variance in the resulting GP model.
基金Project supported by the National Natural Science Foundation of China (Grant No. 11604227).
文摘The strong chiroptical effect is highly desirable and has a wide range of applications in biosensing, chiral catalysis,polarization tuning, and chiral photo detection. In this work, we find a simple method to enhance the reflection circular dichroism(CDR) by placing the planar anisotropic chiral metamaterials(i.e., Z-shaped PACMs) on the interface of two media(i.e., Z-PCMI) with a large refractive index difference. The maximum reflection CDR from the complex system can reach about 0.840 when the refractive index is set as ntop = 4.0 and nbottom = 1.49, which is approximately three times larger than that of placing the Z-shaped PACMs directly on the substrate(i.e., Z-PCMS). While the minimum reflection CDR is 0.157 when the refractive index is set as ntop = 1.0 and nbottom = 1.49. So we can get a large available range of reflection CDR from -0.840 to -0.157. Meanwhile, the transmission CDT remains unchanged with the refractive index ntop increment. Our in-depth research indicates that the large reflection CDR is derived from the difference of non-conversion components of the planar anisotropic chiral metamaterials’ reflection matrices. In short, we provide a simple and practical method to enhance the chiroptical effect by changing the refractive index difference between two media without having to design a complex chiral structure.
文摘Multi-energy flow (MEF) coupling is one of the key features of the energy Internet and integrated energy systems that are different from smart grids. With the increasing coupling of heterogeneous energy flow, the system characteristics of coupling are becoming more and more obvious and more complicated. The modeling, analysis and control methods of traditional single flow systems have not been applied directly. Therefore, it is necessary to study the modeling of multi-energy flow coupling, the power flow analysis, optimization and control method of heterogeneous energy flow, which plays the role of multi-energy flow synergy to avoid the adverse effects of coupling. This paper summarizes the current research situation of energy Internet at home and abroad from the aspects of modeling of multi-energy flow, power flow calculation and optimal dispatching, and analyzes the existing problems in the research of these aspects.
