Sixteen tropinone derivatives were prepared,and their antitumor activities against five human cancer cells(HL-60,A-549,SMMC-7721,MCF-7 and SW480)were evaluated with MTS[3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxy methox...Sixteen tropinone derivatives were prepared,and their antitumor activities against five human cancer cells(HL-60,A-549,SMMC-7721,MCF-7 and SW480)were evaluated with MTS[3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxy methoxyphenyl)-2-(4-sulfopheny)-2H-tetrazolium]assay.Most of the derivatives exhibited better activities compared with tropinone at the concentration of 40 pM.Particularly,derivative 6 showed significant activities with IC50 values of 3.39,13.59,6.65,13.09 and 12.38 pM respectively against HL-60,A-549,SMMC-7721,MCF-7 and SW480 cells,which suggested more potent activities than that of cis-dichlorodiamineplatinum(DDP).展开更多
基金supported by the Hundred Talents Program of the Chinese Academy of Sciences(CAS),the Youth Innovation Promotion Association,CAS and the Program of Yunling Scholarship.
文摘Sixteen tropinone derivatives were prepared,and their antitumor activities against five human cancer cells(HL-60,A-549,SMMC-7721,MCF-7 and SW480)were evaluated with MTS[3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxy methoxyphenyl)-2-(4-sulfopheny)-2H-tetrazolium]assay.Most of the derivatives exhibited better activities compared with tropinone at the concentration of 40 pM.Particularly,derivative 6 showed significant activities with IC50 values of 3.39,13.59,6.65,13.09 and 12.38 pM respectively against HL-60,A-549,SMMC-7721,MCF-7 and SW480 cells,which suggested more potent activities than that of cis-dichlorodiamineplatinum(DDP).
