J/ψ production in p+p and p+Pb collisions at ultrarelativistic energies

The production of J/ψ mesons in p+p and p+Pb collisions is studied in the framework of color-glass condensate together with a simple color evaporation model.Considering the nuclear effects with the Glauber–Gribov approach,we calculate the cross section and the nuclear modification factor of forward J/ψ production in p+Pb collisions at s^(1/2) 5:02 TeV.Then,the backward J/ψ production in p+Pb collisions at s^(1/2) 8:16 Te V is also analyzed.In our calculation,the phenomenology KLRAd S/CFT model and the rc BK approach,which are valid at a small x,are used to calculate the three-point function.It is shown that the theoretical results fit well with the experimental data from ALICE and LHCb.

Mechanism of Guilu Erxian Gum in the treatment of osteoporosis based on network pharmacology

Objective:This article uses the method of network pharmacology to study the related mechanism of Guilu Erxian Gum in the treatment of osteoporosis.Methods:Based on the TCMSP database,ETCM database,chemistry database,and DrugBank database,the potential active ingredients and related targets of Guilu Erxian Gum were obtained.The known therapeutic targets of osteoporosis were obtained from OMIM and Genecards databases,and the STRING database was used.A protein interaction network(PPI)of active ingredients-disease targets was established,and the topological parameters of the network were analyzed using Cytoscape 3.8.0 software to obtain key active ingredients and their targets.In R4.0.2,the Bioconductor data package was used to analyze the GO biological function and KEGG pathway analysis of key targets,and obtain the effective ingredients and targets of Guilu Erxian Gum for treating osteoporosis.Results:The prediction results show that Guilu Erxian Gum has 87 active ingredients and 2305 targets,and there are 4141 known therapeutic targets for osteoporosis.The two act together to obtain a total of 71 PPI core genes.The GO biological process analysis yielded 95 entries,and the KEGG pathway analysis yielded 115 pathways.Conclusion:The analysis results show that Guilu Erxian Gum may play an anti-osteoporosis effect by regulating inflammatory factors,promoting osteoblast differentiation,inhibiting osteoclast formation,and improving microcirculation.The pathways involved include TNF signaling pathways,IL-17 signaling pathway,NF-κB signaling pathway,HIF-1 signaling pathway,MAPK signaling pathway,PI3K-Akt signaling pathway,etc.This study provides a theoretical basis for further elucidating the pharmacological mechanism of Guilu Erxian Gum in the treatment of osteoporosis.

Effects of percutaneous intervertebral foraminal BEIS technique on patients with lumbar disc herniation

Objective:To compare the application effects of percutaneous percutanuous intervertebral foraminal BEIS(Broad Easy Immediate Surgery)technique on patients with lumbar disc herniation.Methods:Eighty-six patients with lumbar disc herniation treated in the Seventh People’s Hospital of Zibo City from Mary 2016 to May 2019 were selected and divided into control group and study group according to the simple randomization of random number table method,with 43 cases in each group.Patients in control group were treated with lamina fenestration while patients in study group were treated with percutanuous intervertebral foraminal BEIS technique.The surgical status and hospital stay,complications,pain[Visual Analogue Scale(VAS)score],Oswestry Disability Index(ODI)score and quality of life[MOS 36-item Short From Health Survey(SF-36)]were compared between the two groups.Results:The surgical time in study group was longer than that in control group,and the incision length was shorter than that in control group,and the fluoroscopy frequency was more than that in control group,and the intraoperative blood loss was less than that in control group,and the hospital stay was shorter than that in control group(P<0.05).There were no significant differences in the incidence rates of postoperative complications between the two groups(P>0.05).There were statistically significant differences in the between-group effects,timepoint effects and interaction effects of VAS pain score(P<0.05),and the VAS pain score in study group at 24 h and 1 w after surgery was significantly lower than that in control group(P<0.05).There were no statistically significant differences in the group-between effects and interaction effects of ODI score(P>0.05),and there were statistically significant differences in the time-point effects(P<0.05).There were statistically significant differences in the betweengroup effects,time-point effects and interaction effects of SF-36 score(P<0.05).The ODI score at 3 months after surgery in study group was lower than that in control group while the SF-36 score was higher than that in control group(P<0.05).Conclusion:Compared with traditional lamina fenestration,percutanuous intervertebral foraminal BEIS technique has the advantages of less trauma and quicker postoperative recovery in the treatment of lumbar disc herniation.Self-made simple locator can reduce the fluoroscopy frequency,improve the accuracy of positioning,further reduce surgical trauma and promote recovery of patients.

Enhancing low-temperature NO_x storage and reduction performance of a Pt-based lean NO_x trap catalyst

Two lean NO_x trap(LNT) catalysts, Pt/BaO/CeO_2 + Al_2O_3 and Pt/BaO/CeO_2-Al_2O_3, were prepared and compared for low-temperature(< 250℃) NO_x storage and reduction performance. The influence of the form of ceria on low-temperature NO_x storage and reduction performance of LNT catalysts was investigated with the focus on NO_x storage capacity, NO_x reduction efficiency during lean/rich cycling, product selectivity and thermal stability.Inductively coupled plasma-atomic emission spectrometry(ICP-AES), Brunner-Emmet-T eller(BET), H_2-pulse chemisorption and X-ray diffraction(XRD) were conducted to characterize the physical properties of LNT catalysts. NO_x storage capacity and NO_x conversion efficiency were measured to evaluate NO_x storage and reduction performance of LNT catalysts. Pt/BaO/CeO_2-Al_2O_3 catalyst exhibits higher NO_x storage capacity than Pt/BaO/CeO_2 + Al_2O_3 catalyst in the temperature range of 150-250 ℃. Meanwhile, Pt/BaO/CeO_2-Al_2O_3 catalyst shows better NO_x conversion efficiency and N_2 selectivity. XRD results indicate that the thermal stability of CeO_2-Al_2O_3 complex oxide is superior to that of pure CeO_2. H_2-pulse chemisorption results show that Pt/BaO/CeO_2-Al_2O_3 catalyst has higher Pt dispersion than Pt/BaO/CeO_2 + Al_2O_3 catalyst over fresh and aged samples. The improved physical properties of Pt/BaO/CeO_2-Al_2O_3 catalyst are attributed to enhance the NOx storage and reduction performance over Pt/BaO/CeO_2 + Al_2O_3 catalyst.