The dependence of tumor growth on neovascularization has become an important aspect of cancer biology.Tumor angiogenesis is one of the key mechanisms of tumorigenesis,growth and metastasis.The key events involved in t...The dependence of tumor growth on neovascularization has become an important aspect of cancer biology.Tumor angiogenesis is one of the key mechanisms of tumorigenesis,growth and metastasis.The key events involved in this process are endothelial cell proliferation,migration,and vascular formation.Recent studies have revealed the importance of tumor-associated endothelial cells(TECs)in the development and progression of colorectal cancer(CRC),including epithelial proliferation,stem cell maintenance,angiogenesis,and immune remodeling.Decades of research have identified that the molecular basis of tumor angiogenesis includes vascular endothelial growth factors(VEGFs)and their receptor family,which are the main targets of antiangiogenesis therapy.VEGFs and their receptors play key roles in the pathology of angiogenesis,and their overexpression indicates poor prognosis in CRC.This article reviews the characteristics of the tumor vasculature and the role of TECs in different stages of CRC and immune remodeling.We also discuss the biological effects of VEGFs and their receptor family as angiogenesis regulators and emphasize the clinical implications of TECs in clinical treatment.展开更多
Objective: Erythropoietin (EPO) is a multipotent growth factor, which can stimulate and protect many cells and tissues. It is widely used in clinical treatment of various anemia, including renal anemia and tumor-relat...Objective: Erythropoietin (EPO) is a multipotent growth factor, which can stimulate and protect many cells and tissues. It is widely used in clinical treatment of various anemia, including renal anemia and tumor-related anemia. It has been found that EPO not only promotes bone marrow hematopoietic function, but also plays an important role in non-hematopoietic organs and tissues such as heart, kidney, liver, brain and retina, as well as in the protection of nervous system. In recent years, there have been many studies and reports about EPO on various systems, but the specific mechanism of EPO has not yet been clearly defined. In this paper, the biological characteristics, physiological functions and the mechanism of action of EPO on various important systems are reviewed.展开更多
Breast tissue clip is a kind of tissue marker visible under ultrasound(US),mammogram(MMG),and magnetic resonance imaging(MRI)and could be used to precisely mark the breast lesions and axillary lymph nodes(LN)under US ...Breast tissue clip is a kind of tissue marker visible under ultrasound(US),mammogram(MMG),and magnetic resonance imaging(MRI)and could be used to precisely mark the breast lesions and axillary lymph nodes(LN)under US or MMG guidance. In order to standardize the clinical application of tissue clip,the Chinese Society of Breast Surgery(CSBrS)identified key clinical issues and developed this clinical practice guideline after evaluating the evidence with reference to the GRADE(ie,Grading of Recommendations Assessment,Development,and Evaluation)system and the accessibility in clinical practice.展开更多
基金Supported by the National Natural Science Foundation of China,No.81502564,No.81972598the Natural Science Foundation of Zhejiang Province,No.LY16H160018,No.LY18H160001the scholarship from China Scholarship Council(CSC)under the Grant CSC,No.201706325003
文摘The dependence of tumor growth on neovascularization has become an important aspect of cancer biology.Tumor angiogenesis is one of the key mechanisms of tumorigenesis,growth and metastasis.The key events involved in this process are endothelial cell proliferation,migration,and vascular formation.Recent studies have revealed the importance of tumor-associated endothelial cells(TECs)in the development and progression of colorectal cancer(CRC),including epithelial proliferation,stem cell maintenance,angiogenesis,and immune remodeling.Decades of research have identified that the molecular basis of tumor angiogenesis includes vascular endothelial growth factors(VEGFs)and their receptor family,which are the main targets of antiangiogenesis therapy.VEGFs and their receptors play key roles in the pathology of angiogenesis,and their overexpression indicates poor prognosis in CRC.This article reviews the characteristics of the tumor vasculature and the role of TECs in different stages of CRC and immune remodeling.We also discuss the biological effects of VEGFs and their receptor family as angiogenesis regulators and emphasize the clinical implications of TECs in clinical treatment.
文摘Objective: Erythropoietin (EPO) is a multipotent growth factor, which can stimulate and protect many cells and tissues. It is widely used in clinical treatment of various anemia, including renal anemia and tumor-related anemia. It has been found that EPO not only promotes bone marrow hematopoietic function, but also plays an important role in non-hematopoietic organs and tissues such as heart, kidney, liver, brain and retina, as well as in the protection of nervous system. In recent years, there have been many studies and reports about EPO on various systems, but the specific mechanism of EPO has not yet been clearly defined. In this paper, the biological characteristics, physiological functions and the mechanism of action of EPO on various important systems are reviewed.
文摘Breast tissue clip is a kind of tissue marker visible under ultrasound(US),mammogram(MMG),and magnetic resonance imaging(MRI)and could be used to precisely mark the breast lesions and axillary lymph nodes(LN)under US or MMG guidance. In order to standardize the clinical application of tissue clip,the Chinese Society of Breast Surgery(CSBrS)identified key clinical issues and developed this clinical practice guideline after evaluating the evidence with reference to the GRADE(ie,Grading of Recommendations Assessment,Development,and Evaluation)system and the accessibility in clinical practice.
