Background:This study aimed to evaluate the clinical features of posterior reversible encephalopathy syndrome(PRES)in children.Methods:The medical records of 31 patients from five medical centers who were diagnosed wi...Background:This study aimed to evaluate the clinical features of posterior reversible encephalopathy syndrome(PRES)in children.Methods:The medical records of 31 patients from five medical centers who were diagnosed with PRES from 2001 to 2013 were retrospectively analyzed.In the 31 patients,16 were males,and 15 females,with a median age of 7 years(3-12 years).Patients younger than 10 years accounted for 74.2%of the 31 patients.Results:Seizure,the most common clinical sign,occurred in 29 of the 31 patients.Visual disturbances were also observed in 20 patients.Cerebral imaging abnormalities were bilateral and predominant in the parietal and occipital white matter.In this series,three patients died in the acute phase of PRES.One patient had resolution of neurologic presentation within one week,but no apparent improvement in radiological abnormalities was observed at eight months.One patient showed gradual recovery of both neurologic presentation and radiological abnormalities during follow-up at eight months.One patient developed long-term cortical blindness.All of the PRES patients with hematologic tumor had a worse prognosis than those without hematologic tumor.Conclusions:Seizure is a prevalent characteristic of children with PRES.Poor prognosis can be seen in PRES patients with hematologic tumor.展开更多
文摘Background:This study aimed to evaluate the clinical features of posterior reversible encephalopathy syndrome(PRES)in children.Methods:The medical records of 31 patients from five medical centers who were diagnosed with PRES from 2001 to 2013 were retrospectively analyzed.In the 31 patients,16 were males,and 15 females,with a median age of 7 years(3-12 years).Patients younger than 10 years accounted for 74.2%of the 31 patients.Results:Seizure,the most common clinical sign,occurred in 29 of the 31 patients.Visual disturbances were also observed in 20 patients.Cerebral imaging abnormalities were bilateral and predominant in the parietal and occipital white matter.In this series,three patients died in the acute phase of PRES.One patient had resolution of neurologic presentation within one week,but no apparent improvement in radiological abnormalities was observed at eight months.One patient showed gradual recovery of both neurologic presentation and radiological abnormalities during follow-up at eight months.One patient developed long-term cortical blindness.All of the PRES patients with hematologic tumor had a worse prognosis than those without hematologic tumor.Conclusions:Seizure is a prevalent characteristic of children with PRES.Poor prognosis can be seen in PRES patients with hematologic tumor.
