Histone deacetylases(HDACs)inhibitors are novel in cancer therapy nowadays.HDAC6-selective inhibitors exert advantageous effects due to higher selectivity and less toxicity.We explored the anti-tumor effect and the mo...Histone deacetylases(HDACs)inhibitors are novel in cancer therapy nowadays.HDAC6-selective inhibitors exert advantageous effects due to higher selectivity and less toxicity.We explored the anti-tumor effect and the molecular mechanism of cay 10603,a potent HDAC6 inhibitor in Burkitt's lymphoma cells.Our study revealed cay 10603 inhibited the proliferation of Burkitt's lymphoma cell lines,and induced caspase-dependent apoptosis.Cayl0603 inhibited the expression of CDKs and cyciins to impede cell cycle progression in both Burkitt's lymphoma cell lines.Cay 10603 also showed the additive effect with vpl 6 notably.Our data presented the promising anti-tumor effect of cay 10603 in the Burkitt's lymphoma therapy.展开更多
The effects of basicity and MgO content on the viscosity of SiO2-CaO-MgO-9wt%Al2O3 slags with basicity from 0.4 to 1.0 and MgO content from 13wt%to 19wt%were investigated using the rotating cylinder method. A correlat...The effects of basicity and MgO content on the viscosity of SiO2-CaO-MgO-9wt%Al2O3 slags with basicity from 0.4 to 1.0 and MgO content from 13wt%to 19wt%were investigated using the rotating cylinder method. A correlation between the viscosity and the slag structure was determined by Fourier transform infrared （FTIR） spectroscopy. It is indicated that the complex network structure of the slag melt is depolymerized into simpler network units with increasing basicity or MgO content, resulting in a continuous decrease in viscosity of the slag. The viscosity is strongly dependent on the combined action of basic oxide components in the slag. Under the present experimental conditions, increasing the basicity is found to be more effective than increasing the MgO content in decreasing the viscosity of the slag. At higher temperatures, the increase of basicity or MgO content does not appreciably decrease the viscosity of the slag, as it does at lower tem-peratures. The calculated activation energy of viscous flow is between 154 and 200 kJ＆#183;mol-1, which decreases with an increase in basicity from 0.4 to 1.0 at a fixed MgO content in the range of 13wt%to 19wt%.展开更多
文摘Histone deacetylases(HDACs)inhibitors are novel in cancer therapy nowadays.HDAC6-selective inhibitors exert advantageous effects due to higher selectivity and less toxicity.We explored the anti-tumor effect and the molecular mechanism of cay 10603,a potent HDAC6 inhibitor in Burkitt's lymphoma cells.Our study revealed cay 10603 inhibited the proliferation of Burkitt's lymphoma cell lines,and induced caspase-dependent apoptosis.Cayl0603 inhibited the expression of CDKs and cyciins to impede cell cycle progression in both Burkitt's lymphoma cell lines.Cay 10603 also showed the additive effect with vpl 6 notably.Our data presented the promising anti-tumor effect of cay 10603 in the Burkitt's lymphoma therapy.
基金financially supported by the National Natural Science Foundation of China(No.51174148)
文摘The effects of basicity and MgO content on the viscosity of SiO2-CaO-MgO-9wt%Al2O3 slags with basicity from 0.4 to 1.0 and MgO content from 13wt%to 19wt%were investigated using the rotating cylinder method. A correlation between the viscosity and the slag structure was determined by Fourier transform infrared （FTIR） spectroscopy. It is indicated that the complex network structure of the slag melt is depolymerized into simpler network units with increasing basicity or MgO content, resulting in a continuous decrease in viscosity of the slag. The viscosity is strongly dependent on the combined action of basic oxide components in the slag. Under the present experimental conditions, increasing the basicity is found to be more effective than increasing the MgO content in decreasing the viscosity of the slag. At higher temperatures, the increase of basicity or MgO content does not appreciably decrease the viscosity of the slag, as it does at lower tem-peratures. The calculated activation energy of viscous flow is between 154 and 200 kJ＆#183;mol-1, which decreases with an increase in basicity from 0.4 to 1.0 at a fixed MgO content in the range of 13wt%to 19wt%.
