Objective:To study the correlation of serum Dickkopf-1 (DKK-1) content with bone destruction, inflammatory response and oxidation reaction in patients with gouty arthritis. Methods: A total of 40 patients with acute g...Objective:To study the correlation of serum Dickkopf-1 (DKK-1) content with bone destruction, inflammatory response and oxidation reaction in patients with gouty arthritis. Methods: A total of 40 patients with acute gouty arthritis who were treated in our hospital between 2013 and 2016 were selected as the group A of the study, 56 patients with asymptomatic hyperuricemia who were treated in our hospital during the same period were selected as the group B of the study, and 60 healthy volunteers who received physical examination in our hospital during the same period were selected as the control group of the study. The serum was collected to detect the contents of DKK-1, bone destruction indexes, inflammatory response indexes and oxidation reaction indexes.Results:Serum DKK-1, TRACP5b, RANKL,β-CTX, PGE2, sICAM-1, sVCAM-1, sCD14, MDA, 8-OHdG and 3-NT levels of group A and group B were significantly higher than those of control group while SOD and GSH-Px levels were significantly lower than those of control group;serum DKK-1, TRACP5b, RANKL,β-CTX, PGE2, sICAM-1, sVCAM-1, sCD14, MDA, 8-OHdG and 3-NT levels of group A were significantly higher than those of group B while SOD and GSH-Px levels were significantly lower than those of group B;serum DKK-1 level was positively correlated with TRACP5b, RANKL,β-CTX, PGE2, sICAM-1, sVCAM-1, sCD14, MDA, 8-OHdG and 3-NT levels, and negatively correlated with SOD and GSH-Px levels. Conclusion:Abnormally elevated DKK-1 in patients with gouty arthritis can induce articular bone destruction as well as inflammatory response and oxidative stress response activation.展开更多
Background： Atopic dermatitis （AD） is an inflammatory skin disease characterized by chronic recurrent dermatitis with profound itching. Most patients have personal and/or family history of atopic diseases. Several ...Background： Atopic dermatitis （AD） is an inflammatory skin disease characterized by chronic recurrent dermatitis with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria have been proposed for the diagnosis of AD. Although the clinical features of childhood AD have been widely studied, there has been less large-scale study on adult/adolescent AD. The aim of this study was to investigate the clinical features of adult/adolescent patients with chronic symmetrical eczemaJAD and to propose Chinese diagnostic criteria for adult/adolescent AD. Methods： A hospital-based study was performed. Forty-two dermatological centers participated in this study. Adult and adolescent patients （12 years and over） with chronic symmetrical eczema or AD were included in this study. Questionnaires were completed by both patients and-investigators. The valid questionnaires were analyzed using EpiData 3.1 and SPSS 17.0 software. Results： A total of 2662 valid questionnaires were collected （1369 male and 1293 female）. Of all 2662 patients, 2062 （77.5%） patients had the disease after 12 years old, while only 600 （22.5%） patients had the disease before 12 years old, suggesting late-onset eczema/AD is common. Two thousand one hundred and thirty-nine （80.4%） patients had the disease for more than 6 months. One thousand one hundred and forty-four （43.0%） patients had a personal and/or family history of atopic diseases. One thousand five hundred and forty-eight （58.2%） patients had an elevated total serum IgE and/or eosinophilia and/or positive allergen-specific IgE. Based on these clinical and laboratory features, we proposed Chinese criteria for adult/adolescent AD. Of all 2662 patients, 60.3% were satisfied with our criteria, while only 48.2% satisfied with Hanifin Rajka criteria and 32.7% satisfied with Williams criteria, suggesting a good sensitivity of our criteria in adult/adolescent AD patients. Conclusion： Late-onset of eczema or AD is common. The clinical manifestations of AD are heterogeneous. We have proposed Chinese diagnostic criteria for adolescent and adult AD, which are simple and sensitive for diagnosis of adult/adolescent AD.展开更多
We review the research on complex dynamical networks(CDNs)with impulsive effects.We provide a comprehensive and intuitive overview of the fundamental results and recent progress of CDNs with impulsive effects,where im...We review the research on complex dynamical networks(CDNs)with impulsive effects.We provide a comprehensive and intuitive overview of the fundamental results and recent progress of CDNs with impulsive effects,where impulsive effects are considered from two aspects,i.e.,impulsive control and impulsive perturbation.Five aspects of CDNs with impulsive effects are surveyed,including synchronizing impulses,desynchronizing impulses,adaptive-impulsive synchronization,pinning impulsive synchronization,and CDNs with stochastic and impulsive effects.Finally,conclusions and some future research directions are briefly addressed.展开更多
The diagnosis of food allergy in clinical practice has not been standardized,and food allergy is overdiagnosed in patients with atopic dermatitis(AD).This overdiagnosis of food allergy leads to unnecessary elimination...The diagnosis of food allergy in clinical practice has not been standardized,and food allergy is overdiagnosed in patients with atopic dermatitis(AD).This overdiagnosis of food allergy leads to unnecessary elimination diets that may exert potential adverse effects on the health of children with AD.Unlike classic IgE-mediated food allergy,food allergy in patients with AD may manifest as non-eczematous reactions,isolated eczematous reactions,or a combination of these reactions.The diagnosis of food allergy in children with AD should be made based on a thorough clinical history(detailed allergic history and feeding history),clinical manifestations,and laboratory workup including skin prick testing,serum specific IgE measurement,atopy patch testing,and oral food challenges.Once an underlying food allergy is confirmed in a patient with AD,comprehensive management is generally recommended.Avoidance of the food allergen is the main treatment approach,but there is a need for regular clinical follow-up,including evaluation of the nutritional status and supervision of growth and development.Multidisciplinary cooperation between dermatologists,nutritionists,and pediatricians is required.展开更多
文摘Objective:To study the correlation of serum Dickkopf-1 (DKK-1) content with bone destruction, inflammatory response and oxidation reaction in patients with gouty arthritis. Methods: A total of 40 patients with acute gouty arthritis who were treated in our hospital between 2013 and 2016 were selected as the group A of the study, 56 patients with asymptomatic hyperuricemia who were treated in our hospital during the same period were selected as the group B of the study, and 60 healthy volunteers who received physical examination in our hospital during the same period were selected as the control group of the study. The serum was collected to detect the contents of DKK-1, bone destruction indexes, inflammatory response indexes and oxidation reaction indexes.Results:Serum DKK-1, TRACP5b, RANKL,β-CTX, PGE2, sICAM-1, sVCAM-1, sCD14, MDA, 8-OHdG and 3-NT levels of group A and group B were significantly higher than those of control group while SOD and GSH-Px levels were significantly lower than those of control group;serum DKK-1, TRACP5b, RANKL,β-CTX, PGE2, sICAM-1, sVCAM-1, sCD14, MDA, 8-OHdG and 3-NT levels of group A were significantly higher than those of group B while SOD and GSH-Px levels were significantly lower than those of group B;serum DKK-1 level was positively correlated with TRACP5b, RANKL,β-CTX, PGE2, sICAM-1, sVCAM-1, sCD14, MDA, 8-OHdG and 3-NT levels, and negatively correlated with SOD and GSH-Px levels. Conclusion:Abnormally elevated DKK-1 in patients with gouty arthritis can induce articular bone destruction as well as inflammatory response and oxidative stress response activation.
文摘Background： Atopic dermatitis （AD） is an inflammatory skin disease characterized by chronic recurrent dermatitis with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria have been proposed for the diagnosis of AD. Although the clinical features of childhood AD have been widely studied, there has been less large-scale study on adult/adolescent AD. The aim of this study was to investigate the clinical features of adult/adolescent patients with chronic symmetrical eczemaJAD and to propose Chinese diagnostic criteria for adult/adolescent AD. Methods： A hospital-based study was performed. Forty-two dermatological centers participated in this study. Adult and adolescent patients （12 years and over） with chronic symmetrical eczema or AD were included in this study. Questionnaires were completed by both patients and-investigators. The valid questionnaires were analyzed using EpiData 3.1 and SPSS 17.0 software. Results： A total of 2662 valid questionnaires were collected （1369 male and 1293 female）. Of all 2662 patients, 2062 （77.5%） patients had the disease after 12 years old, while only 600 （22.5%） patients had the disease before 12 years old, suggesting late-onset eczema/AD is common. Two thousand one hundred and thirty-nine （80.4%） patients had the disease for more than 6 months. One thousand one hundred and forty-four （43.0%） patients had a personal and/or family history of atopic diseases. One thousand five hundred and forty-eight （58.2%） patients had an elevated total serum IgE and/or eosinophilia and/or positive allergen-specific IgE. Based on these clinical and laboratory features, we proposed Chinese criteria for adult/adolescent AD. Of all 2662 patients, 60.3% were satisfied with our criteria, while only 48.2% satisfied with Hanifin Rajka criteria and 32.7% satisfied with Williams criteria, suggesting a good sensitivity of our criteria in adult/adolescent AD patients. Conclusion： Late-onset of eczema or AD is common. The clinical manifestations of AD are heterogeneous. We have proposed Chinese diagnostic criteria for adolescent and adult AD, which are simple and sensitive for diagnosis of adult/adolescent AD.
基金Project supported by the National Natural Science Foundation of China(No.61673247)the Research Fund for Excellent Young Scholars of Shandong Province,China(No.JQ201719)。
文摘We review the research on complex dynamical networks(CDNs)with impulsive effects.We provide a comprehensive and intuitive overview of the fundamental results and recent progress of CDNs with impulsive effects,where impulsive effects are considered from two aspects,i.e.,impulsive control and impulsive perturbation.Five aspects of CDNs with impulsive effects are surveyed,including synchronizing impulses,desynchronizing impulses,adaptive-impulsive synchronization,pinning impulsive synchronization,and CDNs with stochastic and impulsive effects.Finally,conclusions and some future research directions are briefly addressed.
文摘The diagnosis of food allergy in clinical practice has not been standardized,and food allergy is overdiagnosed in patients with atopic dermatitis(AD).This overdiagnosis of food allergy leads to unnecessary elimination diets that may exert potential adverse effects on the health of children with AD.Unlike classic IgE-mediated food allergy,food allergy in patients with AD may manifest as non-eczematous reactions,isolated eczematous reactions,or a combination of these reactions.The diagnosis of food allergy in children with AD should be made based on a thorough clinical history(detailed allergic history and feeding history),clinical manifestations,and laboratory workup including skin prick testing,serum specific IgE measurement,atopy patch testing,and oral food challenges.Once an underlying food allergy is confirmed in a patient with AD,comprehensive management is generally recommended.Avoidance of the food allergen is the main treatment approach,but there is a need for regular clinical follow-up,including evaluation of the nutritional status and supervision of growth and development.Multidisciplinary cooperation between dermatologists,nutritionists,and pediatricians is required.
