Objective:To evaluate the effect of hematopoietic stem cell transplantation combined with Chinese herbal medicine in treating malignant hematopathy.Methods: Allo bone marrow transplantation (allo BMT) or allo perip...Objective:To evaluate the effect of hematopoietic stem cell transplantation combined with Chinese herbal medicine in treating malignant hematopathy.Methods: Allo bone marrow transplantation (allo BMT) or allo peripheral blood stem cell transplantation (allo PBSCT), with conditioning regimen of 60 Co total body irradiation + Cyclophosphamide (TBI+Cy) or busulfan + cyclophosphamide (Bu+Cy), was used to treat 4 cases of chronic granulocytic leukemia (CGL, 3 of chronic phase and 1 of accelerating phase) and one case of acute non lymphocytic leukemia (ANLL). And auto BMT or auto PBSCT, with conditioning regimen of myleran + cytosino arabinoside +cyclophosphamide (MAC) or MAC+VP16, was used to treat 7 cases of hematopathy, including 5 cases of ANLL (3 of CR 1 and 2 of CR 2) and 2 cases of malignant lymphoma (1 of the first occurrence and 1 of relapse). Chinese herbal medicine was given orally to all the 12 patients after transplantation according to TCM Syndrome Differentiation. Results: All patients were successfully engrafted. Within the median follow up period of 18 (4-70) months, 1 patient (8.3%) died a transplantation related death, 3 ( 25.0% ) relapsed and 8 (66.7%) survived free of original disease. Conclusion: Auto BMT or auto PBSCT in CR 1 stage of acute leukemia could reduce the relapse rate, when there was no matched bone marow donor; allo BMT or allo PBSCT in chronic stage could result in long term disease free survival of patients; Chinese herbal medicine administration in patients of malignant hematopathy after transplantation might reduce the complications and plays certain role in promoting recovery of hematopoietic function.展开更多
文摘Objective:To evaluate the effect of hematopoietic stem cell transplantation combined with Chinese herbal medicine in treating malignant hematopathy.Methods: Allo bone marrow transplantation (allo BMT) or allo peripheral blood stem cell transplantation (allo PBSCT), with conditioning regimen of 60 Co total body irradiation + Cyclophosphamide (TBI+Cy) or busulfan + cyclophosphamide (Bu+Cy), was used to treat 4 cases of chronic granulocytic leukemia (CGL, 3 of chronic phase and 1 of accelerating phase) and one case of acute non lymphocytic leukemia (ANLL). And auto BMT or auto PBSCT, with conditioning regimen of myleran + cytosino arabinoside +cyclophosphamide (MAC) or MAC+VP16, was used to treat 7 cases of hematopathy, including 5 cases of ANLL (3 of CR 1 and 2 of CR 2) and 2 cases of malignant lymphoma (1 of the first occurrence and 1 of relapse). Chinese herbal medicine was given orally to all the 12 patients after transplantation according to TCM Syndrome Differentiation. Results: All patients were successfully engrafted. Within the median follow up period of 18 (4-70) months, 1 patient (8.3%) died a transplantation related death, 3 ( 25.0% ) relapsed and 8 (66.7%) survived free of original disease. Conclusion: Auto BMT or auto PBSCT in CR 1 stage of acute leukemia could reduce the relapse rate, when there was no matched bone marow donor; allo BMT or allo PBSCT in chronic stage could result in long term disease free survival of patients; Chinese herbal medicine administration in patients of malignant hematopathy after transplantation might reduce the complications and plays certain role in promoting recovery of hematopoietic function.
