Mechanisms and applications of antitumor immunotherapy of responsive drug-loaded nanoparticles in breast cancer

During the chemotherapy of tumors,the cytotoxic effect of drugs is vital to kill tumor cells,and the delivery of a chemotherapeutic agent is of great importance for optimal therapeutic effects.The high in vivo clearance rate and low delivery efficiency of conventional chemotherapeutic agents affect the therapeutic effect.In recent years,the responsive drug delivery nanosystem has received increasing concern owing to its excellent biocompatibility,stable delivery performance,and controlled drug release strategies.To lucidly explain the cytocidal and immunotherapeutic effects of such responsive nanosystems in breast cancer,this review discusses the various stimuli and responses of drug-loaded liposomal nanosystems.The light/magnetic response of drug-loaded bionic membranes nanosystems and the heat/magnetic response of drug-loaded iron oxide nanosystems are also elaborated.Their cancer cell-killing efficacy and antitumor immunotherapeutic effects are also scrutinized.

Manipulation of π-aromatic conjugation in two-dimensional Sn-organic materials for efficient lithium storage

Sn-based materials are promising candidates for lithium storage but suffer generally from huge volume change during the(de)lithiation processes.Sn-organic materials with monodispersed Sn centers surrounded by lithium active ligands can alleviate the volume change of anode materials based on reversible(de)lithiation processes.However,the structural factors governing the kinetics of lithium storage and utilization efficiency of active sites are not well understood to date.Herein,we report three two-dimensional Sn-organic materials with enhanced lithium storage performance by manipulation ofπ-aromatic conjugation of the ligands.The increasingπ-aromatic conjugation plays a key role in promoting efficient lithium storage,and the volume expansion during the(de)lithiation reaction is suppressed in these Sn-organic materials.This work reveals that theπ-aromatic conjugation of the ligand is crucial for improving the kinetics of lithium storage and the utilization of active sites in metalorganic materials with minimised volume expansion.

Cucurbit[8]uril-mediated phosphorescent supramolecular foldamer for antibiotics sensing in water and cells

A phosphorescent supramolecular foldamer is conveniently constructed by the 1:1 host-guest complexation with cucurbit[8]uril and 1,2-diaminocyclohexane-bridged 4-(4-bromophenyl)-pyridinium salt. The tightly compact host-guest complexation in molecular foldamer can greatly suppress the fluorescence emissive channel and promote the intersystem crossing from singlet to triplet states, thus leading to the green phosphorescence at ambient temperature in aqueous solution. More intriguingly, the phosphorescence emission shows very rapid and sensitive responsiveness to different antibiotics in both inanimate milieu and living cells. Remarkably, the limit of detection of such binary inclusion complex toward sulfamethazine can reach as low as 1.86 × 10^(-7) mol/L. Thus, it is envisaged that this supramolecular nanoplatform featuring unique complexation-enhanced phosphorescence emission may hold great promise in sensing and detecting many other biological targets under physiological environment.

Synergistic activation of photoswitchable supramolecular assembly based on sulfonated crown ether and dithienylethene derivative

Conformational regulation among two or more distant sites is not only one of the main pathways to accomplish multiple tasks in complex biological systems but also represents a powerful strategy to obtain stimuli-responsive supramolecular nanoconstructs with tailored physicochemical performance.We herein report the fabrication of a photochromic supramolecular assembly,which can be synergistically activated by the conformational regulation with bis(4,8-disulfonato-1,5-naphtho)-32-crown-8 and then reversibly switched by the through-space communication between restricted stilbazolium salt and photochromic dithienylethene.This work demonstrates that the synergistic conformational modulation via intra-and intermolecular interactions can be developed as a generalizable approach to construct more advanced biomimetic nanomaterials.