Herein,we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with methanol.By simply changing the base,a broad range of structurally diverse ketones,could be selectively and ...Herein,we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with methanol.By simply changing the base,a broad range of structurally diverse ketones,could be selectively and efficiently converted to the correspondingβ-methylated secondary alcohols or secondary alcohols.Remarkably,this catalytic system was very effective for the synthesis of bio-related molecules and deuterated alcohols,as well as the three-component coupling between methyl ketones,primary alcohols,and methanol.The reaction mechanism was further revealed by experiment and DFT mechanistic investigations.展开更多
基金supported by the National Natural Science Foundation of China(NSFC,Nos.22002023,21973113,21977019)the Guangdong Natural Science Funds for Distin-guished Young Scholar(No.2015A030306027)+1 种基金the Tip-top Youth Talents of Guangdong special support program(No.20153100042090537)the Fundamental Research Funds for the Central Universities。
文摘Herein,we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with methanol.By simply changing the base,a broad range of structurally diverse ketones,could be selectively and efficiently converted to the correspondingβ-methylated secondary alcohols or secondary alcohols.Remarkably,this catalytic system was very effective for the synthesis of bio-related molecules and deuterated alcohols,as well as the three-component coupling between methyl ketones,primary alcohols,and methanol.The reaction mechanism was further revealed by experiment and DFT mechanistic investigations.
