期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Aβ40和hIAPP在溶液和表面的成核与交叉成核聚集行为
1
作者 刘苗苗 王文娟 +1 位作者 郝秀萍 董晓燕 《物理化学学报》 SCIE CAS CSCD 北大核心 2022年第3期91-100,共10页
阿尔茨海默氏病(AD)和2型糖尿病(T2DM)是常见的由蛋白质错误折叠引起的疾病,作为与此二者相关的致病蛋白,淀粉样β蛋白(Aβ)和人胰岛淀粉样多肽(hIAPP)的交叉聚集行为暗示了AD和T2DM的相关性。然而,Aβ和hIAPP在体内的交叉聚集过程尚不... 阿尔茨海默氏病(AD)和2型糖尿病(T2DM)是常见的由蛋白质错误折叠引起的疾病,作为与此二者相关的致病蛋白,淀粉样β蛋白(Aβ)和人胰岛淀粉样多肽(hIAPP)的交叉聚集行为暗示了AD和T2DM的相关性。然而,Aβ和hIAPP在体内的交叉聚集过程尚不明确。为了更好地模拟体内环境特征,即同时存在不同形式的淀粉样蛋白聚集体,且少量的聚集体附着在血管壁上会成为聚集过程的种子,本文以硫代黄素T荧光测定,原子力显微镜,圆二色光谱,石英晶体微天平以及MTT法作为研究手段,探究了Aβ和hIAPP在溶液和固体表面的成核与交叉成核聚集行为。结果表明,少量的Aβ40和hIAPP种子(单体浓度的1/50)即可显著改变异源聚集的聚集路径,形成具有不同形态且含有更多β-折叠结构的异源聚集体,导致更高的细胞毒性。溶液和固体表面上的结果均证明异源成核聚集效率低于同源聚集,且异源聚集的特征很大程度上取决于种子类型。此外,不同于溶液中所得结果,hIAPP种子在固体表面的交叉成核聚集效率显著高于Aβ40种子,证明了界面性质对交叉聚集过程的影响。这些结论对于理解淀粉样蛋白交叉聚集过程具有重要意义。 展开更多
关键词 淀粉样Β蛋白 人胰岛淀粉样多肽 淀粉样蛋白聚集 交叉成核 界面
下载PDF
An Energy-Efficient Query Based on Variable Region for Large-Scale Smart Grid
2
作者 Yan Wang Qingxu Deng +2 位作者 Genghao Liu xiuping hao Baoyan Song 《China Communications》 SCIE CSCD 2016年第10期119-136,共18页
The state-of-the-art query techniques in power grid monitoring systems focus on querying history data, which typically introduces an unwanted lag when the systems try to discover emergency situations. The monitoring d... The state-of-the-art query techniques in power grid monitoring systems focus on querying history data, which typically introduces an unwanted lag when the systems try to discover emergency situations. The monitoring data of large-scale smart grids are massive, dynamic and highly dimensional, so global query, the method widely adopted in continuous queries in Wireless Sensor Networks(WSN), is rendered not suitable for its high energy consumption. The situation is even worse with increasing application complexity. We propose an energy-efficient query technique for large-scale smart grids based on variable regions. This method can query an arbitrary region based on variable physical windows, and optimizes data retrieve paths by a key nodes selection strategy. According to the characteristics of sensing data, we introduce an efficient filter into the each query subtree to keep non-skyline data from being retrieved. Experimental results show that our method can efficiently return the overview situation of any query region. Compared to TAG and ESA, the average query efficiency of our approach is improved by 79% and 46%, respectively; the total energy consumption of regional query is decreased by 82% and 50%, respectively. 展开更多
关键词 smart grid monitoring system wireless sensor network key node skyline query
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部