Recovering skin-nerve interaction by nanoscale metal-organic framework for diabetic ulcers healing

Skin-nerve interaction plays an important role in promoting wound healing.However,in diabetic ulcers(DUs),the diabetic periphery neuropathy and excessive levels of reactive oxygen species(ROS)block skin-nerve interaction and further impede the DUs healing.Herein,we developed a nanoscale metal-organic framework loaded with nerve growth factor(NGF/Ce-UiO-66,denoted NGF/CU)for the treatment of DUs.The Ce-UiO-66(CU)was applied as an antioxidant to scavenge ROS and reduce the inflammatory response while the NGF aided in the recovery of cutaneous nerves to further promote DUs healing.Both in vitro and in vivo experiments revealed the effective ability of NGF/CU for DUs healing.Subsequent RNA sequencing analysis revealed the mechanism that NGF/CU can improve wound healing by inhibiting the NF-κB signaling pathway and recovering the neuroendocrine system of the skin.This strategy of nerve regulation will provide more ideas for the treatment of DUs and other organ injuries.

Spectral computed tomography-guided photothermal therapy of osteosarcoma by bismuth sulfide nanorods

Osteosarcoma(OS)is the most normally primary malignant bone cancer in adolescents.Due to their analogous X-ray attenuation properties,healthy bones and malignancies with iodine enhancement cannot be distinguished by conventional computed tomography(CT).As one kind of spectral CT,dual-energy CT(DECT)offers multiple functions for material separation and cancer treatments.Herein,bismuth sulfide(Bi_(2)S_(3))nanorods(NRs)were synthesized as special contrast agents(CAs)for DECT,which have superior imaging properties than clinical iodine CAs.At the same time,the high photothermal conversion rates of Bi_(2)S_(3)NRs can be used for DECT-guided photothermal therapy(PTT)to destroy OS and inhibit tumor growth under the guidance of DECT imaging.Importantly,DECT imaging real-timely monitored that PTT could accelerate the diffusion of Bi2S3 NRs in the tumor,obtaining detailed information on the internal distribution of nanomaterials in tumors around the bone to avoid injury to normal tissues by PTT.Overall,the proposed strategy of DECT imaging-guided PTT appears enormous promise for bone disease treatment.

Dual-modality magnetic resonance/optical imaging-guided sonodynamic therapy of pancreatic cancer with metal-organic nanosonosensitizer

Sonodynamic therapy(SDT)has been more attractive to carry out oncology treatments in recent years.However,imagingguided sonodynamic therapeutic nanomedicine is still a shortage in SDT development.In this work,we designed and fabricated an organic SDT system based on combination of 1,2,4,5-tetrakis(4-carboxyphenyl)-porphyrin(TCPP)and gadolinium(III)(Gd^(3+))creatively(Gd-PPNs).Gd^(3+)was traditionally used to be T_(1)-weighted magnetic resonance imaging(MRI)contrast agent and TCPP was initiatively a fluorescence imaging organic media.Therefore,these new designed nanoparticles have immense potential to integrate MRI and FLI to visualize the Gd-PPNs accumulating and keeping in tumor for a long time,which could be applied for guidance of SDT on tumors in clinical practice.Importantly,excellent SDT efficiency under imaging guidance was verified both in vitro and in vivo in this work.Our findings suggested that Gd-PPNs,as innovative imaging and therapy combinational nanomedicines,were successfully synthesized and were proved to possess excellent imaging-guided sonodynamic therapeutic efficacy.Moreover,this new designed sonosensitizer had great biocompatibility to avoid unnecessary biotoxicity.Overall,this strategy shed light on the MRI/FLI-guidance and successfully induced pancreatic tumor growth inhibition by sonodynamic therapy.