TCMSTD 1.0: a systematic analysis of the traditional Chinese medicine system toxicology database

Dear Editor,The safety and modernization of traditional Chinese medicine (TCM) are significant concerns for users’ lives and health. Recently, the adverse effects caused by TCM and traditional nontoxic TCM have been frequently reported (Joo et al., 2020;Liu et al., 2021). As the safety of TCM continues to attract widespread attention, many researchers have been investigating the toxicity of TCM in regard to the toxic ingredients, effects, mechanisms, and detoxification strategies in TCM (Figure S1 in Supporting Information). Although some TCMs cause toxic reactions, they also play key roles in treating certain unignorable diseases (Fang et al., 2022).Therefore, toxicity research is crucial and urgently needed to develop and safely use TCM.

腹腔镜胃癌根治术中患者体温变化与压力性损伤及受压部位微环境的相关性分析

目的 分析腹腔镜下胃癌根治患者术中体温变化与压力性损伤及受压部位微环境的相关性。方法 回顾分析2019年9月至2022年9月火箭军特色医学中心收治的95例行腹腔镜下胃癌根治术的患者,按照其术后压力性损伤发生情况,分别纳入发生组、未发生组。对比2组患者手术开始时,以及手术开始后30 min、1 h、1.5 h、2 h体温和受压部位微环境变化,微环境包括肩部、臀部、足跟温度及湿度。使用Pearson相关性分析,计算体温与微环境的关系,并运用Logistic多因素回归分析,总结低温、微环境变化对压力性损伤发生的影响。结果 95例患者中,共有17例术后发生压力性损伤,发生率为17.89%,其中压力性损伤Ⅰ期12例、Ⅱ期4例、Ⅲ期1例。发生组手术开始后1.5 h、2 h体温,肩部、臀部、足跟温度、湿度较手术开始时上升,且高于未发生组同期水平,差异有统计学意义(P <0.05)。Pearson相关性分析示,患者术中体温与肩部、臀部、足跟温度及湿度均呈正相关(P<0.05)。Logistic多因素回归分析示,合并糖尿病、术中低血压、术中最高体温≥37.4℃、受压部位温度变化≥0.5℃、受压部位湿度变化≥1%均为影响腹腔镜胃癌根治术患者压力性损伤的独立危险因素(P<0.05)。结论 腹腔镜胃癌根治术患者术后发生压力性损伤患者术中体温较高、受压部位微环境变化更为明显,体温上升、受压部位微环境变化与压力性损伤发生风险上升有关。