The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironmen...The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironment.Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors,generating exosomes,releasing nutrients,reshaping the extracellular matrix,and suppressing the function of immune cells.CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers.Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials.Here,we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.We hope that summarizing CAFrelated studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer.展开更多
Tissue-resident stem cells are a group of stem cells distinguished by their capacity for self-renewal and multilineage differentiation capability with tissue specificity.Among these tissue-resident stem cells,skeletal...Tissue-resident stem cells are a group of stem cells distinguished by their capacity for self-renewal and multilineage differentiation capability with tissue specificity.Among these tissue-resident stem cells,skeletal stem cells(SSCs)were discovered in the growth plate region through a combination of cell surface markers and lineage tracing series.With the process of unravelling the anatomical variation of SSCs,researchers were also keen to investigate the developmental diversity outside the long bones,including in the sutures,craniofacial sites,and spinal regions.Recently,fluorescence-activated cell sorting,lineage tracing,and single-cell sequencing have been used to map lineage trajectories by studying SSCs with different spatiotemporal distributions.The SSC niche also plays a pivotal role in regulating SSC fate,such as cell-cell interactions mediated by multiple signalling pathways.This review focuses on discussing the spatial and temporal distribution of SSCs,and broadening our understanding of the diversity and plasticity of SSCs by summarizing the progress of research into SSCs in recent years.展开更多
基金National Natural Science Foundation of China,Grant/Award Numbers:81602471,81672729,81972453,81972597Natural Science Foundation of Zhejiang Province,Grant/Award Numbers:LY19H160055,LY19H160059,LR22H160011+2 种基金Natural Science Foundation of Ningbo,Grant/Award Number:2019A610315Cixi Agricultural and Social Development Science and Technology Project,Grant/Award Number:CN2020006Zheng Shu Medical Elite Scholarship Fund。
文摘The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironment.Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors,generating exosomes,releasing nutrients,reshaping the extracellular matrix,and suppressing the function of immune cells.CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers.Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials.Here,we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.We hope that summarizing CAFrelated studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer.
基金This work was supported in part by National Key R&D Program of China,No.2020YFA0112900(to RX)National Natural Science Foundation of China,Nos.81972034,92068104(to RX),82002262(to NL)Natural Science Foundation of Fujian Province,No.2022J06003(to RX).
文摘Tissue-resident stem cells are a group of stem cells distinguished by their capacity for self-renewal and multilineage differentiation capability with tissue specificity.Among these tissue-resident stem cells,skeletal stem cells(SSCs)were discovered in the growth plate region through a combination of cell surface markers and lineage tracing series.With the process of unravelling the anatomical variation of SSCs,researchers were also keen to investigate the developmental diversity outside the long bones,including in the sutures,craniofacial sites,and spinal regions.Recently,fluorescence-activated cell sorting,lineage tracing,and single-cell sequencing have been used to map lineage trajectories by studying SSCs with different spatiotemporal distributions.The SSC niche also plays a pivotal role in regulating SSC fate,such as cell-cell interactions mediated by multiple signalling pathways.This review focuses on discussing the spatial and temporal distribution of SSCs,and broadening our understanding of the diversity and plasticity of SSCs by summarizing the progress of research into SSCs in recent years.
