Waterborne viruses that can be harmful to human health pose significant challenges globally,affecting health care systems and the economy.Identifying these waterborne pathogens is essential for preventing diseases and...Waterborne viruses that can be harmful to human health pose significant challenges globally,affecting health care systems and the economy.Identifying these waterborne pathogens is essential for preventing diseases and protecting public health.However,handling complex samples such as human and wastewater can be challenging due to their dynamic and complex composition and the ultralow concentration of target analytes.This review presents a comprehensive overview of the latest breakthroughs in waterborne virus biosensors.It begins by highlighting several promising strategies that enhance the sensing performance of optical and electrochemical biosensors in human samples.These strategies include optimizing bioreceptor selection,transduction elements,signal amplification,and integrated sensing systems.Furthermore,the insights gained from biosensing waterborne viruses in human samples are applied to improve biosensing in wastewater,with a particular focus on sampling and sample pretreatment due to the dispersion characteristics of waterborne viruses in wastewater.This review suggests that implementing a comprehensive system that integrates the entire waterborne virus detection process with high-accuracy analysis could enhance virus monitoring.These findings provide valuable insights for improving the effectiveness of waterborne virus detection,which could have significant implications for public health and environmental management.展开更多
Salicylaldehyde containing biaryls are efficiently synthesized via an unprecedented amine promoted Diels-Alderretro-Diels-Alder cascade reaction of ynals with 2-pyrones in good yields.The reaction is instrumentally me...Salicylaldehyde containing biaryls are efficiently synthesized via an unprecedented amine promoted Diels-Alderretro-Diels-Alder cascade reaction of ynals with 2-pyrones in good yields.The reaction is instrumentally metalfree,operationally simple and mild,and tolerates a diverse array of functional groups.展开更多
基金supported by the Research Center for Industries of the Future of Westlake University,China(Grant No.:210230006022219/001)the National Natural Science Foundation of China(Grant No.:82104122)+1 种基金Westlake University,China(Grant No.:10318A992001)the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang,China(Grant No.:2020R01005).
文摘Waterborne viruses that can be harmful to human health pose significant challenges globally,affecting health care systems and the economy.Identifying these waterborne pathogens is essential for preventing diseases and protecting public health.However,handling complex samples such as human and wastewater can be challenging due to their dynamic and complex composition and the ultralow concentration of target analytes.This review presents a comprehensive overview of the latest breakthroughs in waterborne virus biosensors.It begins by highlighting several promising strategies that enhance the sensing performance of optical and electrochemical biosensors in human samples.These strategies include optimizing bioreceptor selection,transduction elements,signal amplification,and integrated sensing systems.Furthermore,the insights gained from biosensing waterborne viruses in human samples are applied to improve biosensing in wastewater,with a particular focus on sampling and sample pretreatment due to the dispersion characteristics of waterborne viruses in wastewater.This review suggests that implementing a comprehensive system that integrates the entire waterborne virus detection process with high-accuracy analysis could enhance virus monitoring.These findings provide valuable insights for improving the effectiveness of waterborne virus detection,which could have significant implications for public health and environmental management.
基金The work was supported by the National Natural Science Foundation of China(No.21738002).
文摘Salicylaldehyde containing biaryls are efficiently synthesized via an unprecedented amine promoted Diels-Alderretro-Diels-Alder cascade reaction of ynals with 2-pyrones in good yields.The reaction is instrumentally metalfree,operationally simple and mild,and tolerates a diverse array of functional groups.
