The fifth generation (5G) wireless communication is currently a hot research topic and wireless communication systems on high speed railways (HSR) are important applications of 5G technologies. Existing stud- ies ...The fifth generation (5G) wireless communication is currently a hot research topic and wireless communication systems on high speed railways (HSR) are important applications of 5G technologies. Existing stud- ies about 5G wireless systems on high speed railways (HSR) often utilize ideal channel parameters and are usually based on simple scenarios. In this paper, we evaluate the down- link throughput of 5G HSR communication systems on three typical scenarios including urban, cutting and viaduct with three different channel estimators. The channel parameters of each scenario are generated with tapped delay line (TDL) models through ray-tracing sim- ulations, which can be considered as a good match to practical situations. The channel estimators including least square (LS), linear minimum mean square error (LMMSE), and our proposed historical information based ba- sis expansion model (HiBEM). We analyze the performance of the HiBEM estimator in terms of mean square error (MSE) and evaluate the system throughputs with different channel estimates over each scenario. Simulation results are then provided to corroborate our proposed studies. It is shown that our HiBEM estimator outperforms other estimators and that the sys-tem throughput can reach the highest point in the viaduct scenario.展开更多
The lacunar-canalicular system(LCS)is acknowledged to directly participate in bone tissue remodeling.The fluid flow in the LCS is synergic driven by the pressure gradient and electric field loads due to the electro-me...The lacunar-canalicular system(LCS)is acknowledged to directly participate in bone tissue remodeling.The fluid flow in the LCS is synergic driven by the pressure gradient and electric field loads due to the electro-mechanical properties of bone.In this paper,an idealized annulus Maxwell fluid flow model in bone canaliculus is established,and the analytical solutions of the fluid velocity,the fluid shear stress,and the fluid flow rate are obtained.The results of the fluid flow under pressure gradient driven(PGD),electric field driven(EFD),and pressure-electricity synergic driven(P-ESD)patterns are compared and discussed.The effects of the diameter of canaliculi and osteocyte processes are evaluated.The results show that the P-ESD pattern can combine the regulatory advantages of single PGD and EFD patterns,and the osteocyte process surface can feel a relatively uniform shear stress distribution.As the bone canalicular inner radius increases,the produced shear stress under the PGD or P-ESD pattern increases slightly but changes little under the EFD pattern.The increase in the viscosity makes the flow slow down but does not affect the fluid shear stress(FSS)on the canalicular inner wall and osteocyte process surface.The increase in the high-valent ions does not affect the flow velocity and the flow rate,but the FSS on the canalicular inner wall and osteocyte process surface increases linearly.In this study,the results show that the shear stress sensed by the osteocyte process under the P-ESD pattern can be regulated by changing the pressure gradient and the intensity of electric field,as well as the parameters of the annulus fluid and the canaliculus size,which is helpful for the osteocyte mechanical responses.The established model provides a basis for the study of the mechanisms of electro-mechanical signals stimulating bone tissue(cells)growth.展开更多
We apply the adaptive moving window method of Sun et al. to the most recent catalog data and the data recorded by portable stations to construct the velocity structure of the crust and upper mantle, and to determine t...We apply the adaptive moving window method of Sun et al. to the most recent catalog data and the data recorded by portable stations to construct the velocity structure of the crust and upper mantle, and to determine the depth of the Moho interface beneath the Tibetan plateau and other areas of China. We first select 2 600 locations in the study region with 1° intervals, then at each location invert for a five-layer 1-D P-wave velocity model from the surface down to the uppermost mantle by performing a Monte Carlo random search. The Moho depth at each location is then determined, and the Moho interface beneath the study region is obtained through proper interpolation with certain smoothing. Compared to depths obtained by previous studies, our results show more accurate Moho depths in the Tibetan plateau, Tianshan region and other areas of the study region.展开更多
Malignant melanoma(MM)is an extremely aggressive and fatal form of skin cancer that primarily affects the bottom layer of the epidermis and is associated with poor clinical outcomes.Early-stage MM is typically treated...Malignant melanoma(MM)is an extremely aggressive and fatal form of skin cancer that primarily affects the bottom layer of the epidermis and is associated with poor clinical outcomes.Early-stage MM is typically treated through surgical removal,while chemotherapy and radiotherapy are common conventional treatment options that come with harmful side effects.Emerging therapies such as immunotherapy,photodynamic therapy,biologic therapy,and photothermal therapy present hopeful options for treatment due to their effective and secure drug delivery methods.To address the limitations of current treatment options,advanced methods of drug delivery for subcutaneous MM are being developed,with hydrogels emerging as a promising alternative.To date,significant advancements have been made in the treatment of MM through the use of hydrogels-based drug delivery systems through focal plastering,injection,implantation,and microneedles.Recent research on hydrogel-based drug delivery systems that integrate multiple therapies for the treatment of subcutaneous MM is discussed in this review.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.61522109,61671253,61571037and 91738201)the Fundamental Research Funds for the Central Universities(No.2016JBZ006)+1 种基金the Natural Science Foundation of Jiangsu Province(Grant Nos.BK20150040and BK20171446)the Key Project of Natural Science Research of Higher Education Institutions of Jiangsu Province(No.15KJA510003)
文摘The fifth generation (5G) wireless communication is currently a hot research topic and wireless communication systems on high speed railways (HSR) are important applications of 5G technologies. Existing stud- ies about 5G wireless systems on high speed railways (HSR) often utilize ideal channel parameters and are usually based on simple scenarios. In this paper, we evaluate the down- link throughput of 5G HSR communication systems on three typical scenarios including urban, cutting and viaduct with three different channel estimators. The channel parameters of each scenario are generated with tapped delay line (TDL) models through ray-tracing sim- ulations, which can be considered as a good match to practical situations. The channel estimators including least square (LS), linear minimum mean square error (LMMSE), and our proposed historical information based ba- sis expansion model (HiBEM). We analyze the performance of the HiBEM estimator in terms of mean square error (MSE) and evaluate the system throughputs with different channel estimates over each scenario. Simulation results are then provided to corroborate our proposed studies. It is shown that our HiBEM estimator outperforms other estimators and that the sys-tem throughput can reach the highest point in the viaduct scenario.
基金supported by the National Natural Science Foundation of China(Nos.11972242 and 11632013)the China Postdoctoral Science Foundation(No.2020M680913)。
文摘The lacunar-canalicular system(LCS)is acknowledged to directly participate in bone tissue remodeling.The fluid flow in the LCS is synergic driven by the pressure gradient and electric field loads due to the electro-mechanical properties of bone.In this paper,an idealized annulus Maxwell fluid flow model in bone canaliculus is established,and the analytical solutions of the fluid velocity,the fluid shear stress,and the fluid flow rate are obtained.The results of the fluid flow under pressure gradient driven(PGD),electric field driven(EFD),and pressure-electricity synergic driven(P-ESD)patterns are compared and discussed.The effects of the diameter of canaliculi and osteocyte processes are evaluated.The results show that the P-ESD pattern can combine the regulatory advantages of single PGD and EFD patterns,and the osteocyte process surface can feel a relatively uniform shear stress distribution.As the bone canalicular inner radius increases,the produced shear stress under the PGD or P-ESD pattern increases slightly but changes little under the EFD pattern.The increase in the viscosity makes the flow slow down but does not affect the fluid shear stress(FSS)on the canalicular inner wall and osteocyte process surface.The increase in the high-valent ions does not affect the flow velocity and the flow rate,but the FSS on the canalicular inner wall and osteocyte process surface increases linearly.In this study,the results show that the shear stress sensed by the osteocyte process under the P-ESD pattern can be regulated by changing the pressure gradient and the intensity of electric field,as well as the parameters of the annulus fluid and the canaliculus size,which is helpful for the osteocyte mechanical responses.The established model provides a basis for the study of the mechanisms of electro-mechanical signals stimulating bone tissue(cells)growth.
基金supported by the Defense Threat Reduction Agency under Contract Number DTRA01-00-C-0024supported by Chinese Academy of Sciences fund KJCX2-EW-121
文摘We apply the adaptive moving window method of Sun et al. to the most recent catalog data and the data recorded by portable stations to construct the velocity structure of the crust and upper mantle, and to determine the depth of the Moho interface beneath the Tibetan plateau and other areas of China. We first select 2 600 locations in the study region with 1° intervals, then at each location invert for a five-layer 1-D P-wave velocity model from the surface down to the uppermost mantle by performing a Monte Carlo random search. The Moho depth at each location is then determined, and the Moho interface beneath the study region is obtained through proper interpolation with certain smoothing. Compared to depths obtained by previous studies, our results show more accurate Moho depths in the Tibetan plateau, Tianshan region and other areas of the study region.
基金supported by National Natural Science Foundation of China(82203961 and 82302816)Jiangsu science and technology project(BK20230145)Nanjing health science and technology development project(YKK23098).
文摘Malignant melanoma(MM)is an extremely aggressive and fatal form of skin cancer that primarily affects the bottom layer of the epidermis and is associated with poor clinical outcomes.Early-stage MM is typically treated through surgical removal,while chemotherapy and radiotherapy are common conventional treatment options that come with harmful side effects.Emerging therapies such as immunotherapy,photodynamic therapy,biologic therapy,and photothermal therapy present hopeful options for treatment due to their effective and secure drug delivery methods.To address the limitations of current treatment options,advanced methods of drug delivery for subcutaneous MM are being developed,with hydrogels emerging as a promising alternative.To date,significant advancements have been made in the treatment of MM through the use of hydrogels-based drug delivery systems through focal plastering,injection,implantation,and microneedles.Recent research on hydrogel-based drug delivery systems that integrate multiple therapies for the treatment of subcutaneous MM is discussed in this review.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.11972242 and 12272250)China Postdoctoral Science Foundation(Grant No.2020M680913)+1 种基金Shanxi Scholarship Council of China and Shanxi Posigraduate Innovation ProjectShanxi Huajin Orthopaedic Public Foundation.