Coal Seam Permeability Improvement and CBM Production Enhancement by Enlarged Borehole: Mechanism and Application

The permeability is a key factor to determine the efficiency of coalbed methane(CBM)production.The borehole enlargement technology using hydraulic and mechanical measures to cut coal is an effective method to increase the coal seam permeability and improve the efficiency of gas drainage.Reasonable design of the layout of boreholes is the prerequisite for efficient and economical gas drainage.In this paper,based on the strain-softening model,the stress and permeability model of the coal seam around the enlarged borehole was built,and based on the dual-medium model,the gas migration model in the coal seam was established.Then the borehole enlargement gas drainage engineering of E9/10 coal seam in Pingdingshan No.8 coal mine was simulated by using COMSOL Multiphysics software.The distribution of stress and permeability in the coal seam around a borehole was analyzed,and the reasonable borehole radius of 0.25 m and reasonable borehole spacing of 6 m were determined.Finally,in Pingdingshan No.8 coal mine,field application was carried out in E9/10 coal seam-21070 working face from the high-level gas drainage roadway.The results show that the actual average coal slag discharge rate is 77.82%,which achieved borehole enlargement.The natural gas flow rate from an enlarged borehole is 2.3–7.3 times that of a normal borehole,and the influence range of enlarged boreholes is more than 6 m.The average gas drainage concentration of a group of enlarged boreholes is about 42%,and the average gas drainage amount is about 0.53 m3/min.After two months of gas extraction,the outburst risk in this area was eliminated,which provides a guarantee for safe coal mining.

Research on Reliability of Desorption Indexes of Drilling Cuttings(K_(1)andΔh_(2)):A Case-Based on Pingdingshan Mining Region,China

To accurately predict the risk of coal and gas outburst and evaluate the reliability of desorption indexes of drilling cuttings(K_(1) andΔh_(2))in No.16 coal seam of Pingmei No.12 coal mine,two sets of coal samples were selected from the target coal seams for proximate analyses,methane adsorption/desorption tests,and desorption indexes of drilling cuttings tests.The results indicated that the desorption volume in the initial stage of desorption is large,and increases slowly in the later stage.The methane desorption volume of PMD1 and PMD2 coal samples accounts for 15.14%-18.09%and 15.72%-18.17%respectively in the first 1 min,and 43.92%-48.55%and 41.87%-52.25%respectively in the first 10 min in the 120 min desorption tests.Both K_(1) andΔh_(2) present power function relationships with methane pressure.Similarly,the power function relationships also can be found between the initial desorption characteristics(Q1 and Q4-5)and the methane pressure.Finally,the average relative error between the measured value and the calculated value of Q1 based on K_(1) is less than that of Q4-5 based onΔh_(2),which indicates that K_(1) is a more reliable index thanΔh_(2) to predict the risk of coal and gas outburst in the No.16 coal seam of Pingmei No.12 coal mine.

Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway

The stimulator of interferon genes(STING)protein is an important and promising innate immune target for tumor therapy.However,the instability of the agonists of STING and their tendency to cause systemic immune activation is a hurdle.The STING activator,cyclic di-adenosine monophosphate(CDA),produced by the modified Escherichia coli Nissle 1917,shows high antitumor activity and effectively reduces the systemic effects of the“off-target”caused by the activation of the STING pathway.In this study,we used synthetic biological approaches to optimize the translation levels of the diadenylate cyclase that catalyzes CDA synthesis in vitro.We developed 2 engineered strains,CIBT4523 and CIBT4712,for producing high levels of CDA while keeping their concentrations within a range that did not compromise the growth.Although CIBT4712 exhibited stronger induction of the STING pathway corresponding to in vitro CDA levels,it had lower antitumor activity than CIBT4523 in an allograft tumor model,which might be related to the stability of the surviving bacteria in the tumor tissue.CIBT4523 exhibited complete tumor regression,prolonged survival of mice,and rejection of rechallenged tumors,thus,offering new possibilities for more effective tumor therapy.We showed that the appropriate production of CDA in engineered bacterial strains is essential for balancing antitumor efficacy and self-toxicity.

喀麦隆新华商的在地适应与创业策略

本文将自20世纪80年代以来在喀麦隆创业的中国大陆移民称为新华商。基于30个案例的深度访谈资料,本文运用机会结构与族裔特征互动模型分析喀麦隆新华商的在地适应与创业策略。研究发现,面对喀麦隆市场开放、国家鼓励外来投资和工业基础薄弱等机会结构,新华商在创业时不仅充分利用了中国轻工业生产与出口的优势,而且还动用了喀麦隆华人社团的强大支持等族裔资本,形成了跨国连接与在地镶嵌两大创业策略。而发展在地社会网络的同时不寻求国籍身份转变、不融入本地社群可以界定为新华商群体的最重要特征。喀麦隆新华商的创业实践反映出“南-南”移民流动框架下国家关系具有平等互惠性,进而使移民跨国创业行动有了更大的策略选择空间。